skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Mass spectrometric immunoassay

Patent ·
OSTI ID:1175578
; ;

Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.

Research Organization:
Intrinsic Bioprobes, Inc., Tempe, AZ (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-91ER61127
Assignee:
Intrinsic Bioprobes, Inc. (Tempe, AZ)
Patent Number(s):
6,974,704
Application Number:
09/808,275
OSTI ID:
1175578
Country of Publication:
United States
Language:
English

References (6)

Direct Analysis of Affinity-Bound Analytes by MALDI/TOF MS journal September 1994
Quantitative profiling of 6-ketoprostaglandin F1α, 2,3-dinor-6-ketoprostaglandin F1α, thromboxane B2 and 2,3-dinor-thromboxane B2 in human and rat urine by immunoaffinity extraction with gas chromatography—mass spectrometry journal January 1989
Immunoaffinity Extraction of 4-Hydroxy-2-(4-methylphenyl)benzothiazole and Its Metabolites for Determination by Gas Chromatography-Mass Spectrometry. journal January 1994
Simultaneous determination of the primary prostanoids prostaglandin E2, prostaglandin F2α and 6-oxoprostaglandin F1α by immunoaffinity chromatography in combination with negative ion chemical ionization gas chromatography—tandem mass spectrometry journal January 1989
Mass Spectrometric Immunoassay journal April 1995
Epitope mapping of the gastrin-releasing peptide/anti-bombesin monoclonal antibody complex by proteolysis followed by matrix-assisted laser desorption ionization mass spectrometry journal September 1994

Similar Records

Mass spectrometric immunoassay
Patent · Tue Jul 16 00:00:00 EDT 2013 · OSTI ID:1175578
Mass spectrometric immunoassay
Patent · Tue Dec 04 00:00:00 EST 2007 · OSTI ID:1175578
Intrinsic Bioprobes, Inc. (Tempe, AZ)
Patent · Tue Jul 15 00:00:00 EDT 2008 · OSTI ID:1175578

Related Subjects

60 APPLIED LIFE SCIENCES