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Nucleic acid encoding DS-CAM proteins and products related thereto

Patent ·
OSTI ID:1175539
In accordance with the present invention, there are provided Down Syndrome-Cell Adhesion Molecule (DS-CAM) proteins. Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention DS-CAM proteins can be employed in a variety of ways, for example, for the production of anti-DS-CAM antibodies thereto, in therapeutic compositions and methods employing such proteins and/or antibodies. DS-CAM proteins are also useful in bioassays to identify agonists and antagonists thereto.
Research Organization:
Cedars Sinai Medical Center, Los Angeles, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG03-92ER61402
Assignee:
Cedars Sinai Medical Center (Los Angeles, CA)
Patent Number(s):
6,960,656
Application Number:
08/956,991
OSTI ID:
1175539
Country of Publication:
United States
Language:
English

References (36)

Identification of a chromosome 18q gene that is altered in colorectal cancers journal January 1990
Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28 journal July 1997
A periodic tryptophan protein 2 gene homologue (PWP2H) in the candidate region of progressive myoclonus epilepsy on 21q22.3 journal January 1996
Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing journal May 1987
Cloning of a delta opioid receptor by functional expression journal December 1992
Mutation analysis of a Sandhoff disease patient in the Maronite community in Cyprus journal August 1994
A reappraisal of non-consensus mRNA splice sites journal January 1991
YAC analysis and minimal tiling path construction for chromosome 21q journal November 1995
A new bacteriophage P1–derived vector for the propagation of large human DNA fragments journal January 1994
BIG-1: A new TAG-1/F3-related member of the immunoglobulin superfamily with neurite outgrowth-promoting activity journal August 1994
Expression of Various NCAM Isoforms in Human Embryonic Muscles: Correlation with Myosin Heavy Chain Phenotypes journal January 1992
Sequence of contactin, a 130-kD glycoprotein concentrated in areas of interneuronal contact, defines a new member of the immunoglobulin supergene family in the nervous system journal October 1988
The Molecular Biology of Axon Guidance journal November 1996
Homophilic and heterophilic binding activities of Nr-CAM, a nervous system cell adhesion molecule. journal October 1992
GENOMICS: The Babel of Bioinformatics journal October 2000
TAG-1/Axonin-1 Is a High-affinity Ligand of Neurocan, Phosphacan/Protein-tyrosine Phosphatase-ζ/β, and N-CAM journal June 1996
Genetic Dissection of Structural and Functional Components of Synaptic Plasticity. III. CREB Is Necessary for Presynaptic Functional Plasticity journal October 1996
Neuronal cell adhesion molecule contactin/F11 binds to tenascin via its immunoglobulin-like domains. journal October 1992
Factors regulating the expression and function of calcium-independent cell adhesion molecules journal October 1993
Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor journal October 1996
Molecular cloning and functional expression of gicerin, a novel cell adhesion molecule that binds to neurite outgrowth factor journal April 1994
Aberrant splicing of neural cell adhesion molecule L1 mRNA in a family with X–linked hydrocephalus journal October 1992
Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3 journal January 1995
BAC and PAC Contigs Covering 3.5 Mb of the Down Syndrome Congenital Heart Disease Region between D21S55 and MX1 on Chromosome 21 journal April 1997
Cell Adhesion Molecules: Implications for a Molecular Histology journal June 1991
The DCC Gene: Structural Analysis and Mutations in Colorectal Carcinomas journal February 1994
Characterization of a Highly Conserved Human Homolog to the Chicken Neural Cell Surface Protein Bravo/Nr-CAM That Maps to Chromosome Band 7q31 journal August 1996
Genetic Dissection of Structural and Functional Components of Synaptic Plasticity. II. Fasciclin II Controls Presynaptic Structural Plasticity journal October 1996
From genes to protein structure and function: novel applications of computational approaches in the genomic era journal January 2000
A mouse cdc25 homolog is differentially and developmentally expressed. journal April 1992
Human cDNA mapping using a high-resolution R-banding technique and fluorescence in situ hybridization journal January 1995
A high-fidelity physical map of human chromosome 21q in yeast artificial chromosomes. journal December 1995
Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin journal August 1988
Functional domain analysis of glass, a zinc-finger-containing transcription factor in Drosophila. journal July 1995
Down syndrome phenotypes: the consequences of chromosomal imbalance. journal May 1994
X–linked spastic paraplegia (SPG1), MASA syndrome and X–linked hydrocephalus result from mutations in the L1 gene journal July 1994