Attachment of second harmonic-active moiety to molecules for detection of molecules at interfaces

Patent · Tue Oct 11 00:00:00 EDT 2005

OSTI ID:1175520

Salafsky, Joshua S.; Eisenthal, Kenneth B.

This invention provides methods of detecting molecules at an interface, which comprise labeling the molecules with a second harmonic-active moiety and detecting the labeled molecules at the interface using a surface selective technique. The invention also provides methods for detecting a molecule in a medium and for determining the orientation of a molecular species within a planar surface using a second harmonic-active moiety and a surface selective technique.

• Research Organization: The Trustees of Columbia University in the City of New York, New York, NY (United States)
• Sponsoring Organization: USDOE
• Assignee: The Trustees of Columbia University in the City of New York (New York, NY)
• Patent Number(s): 6,953,694
• Application Number: 09/731,366
• OSTI ID: 1175520
• Country of Publication: United States
• Language: English

Related Subjects

74 ATOMIC AND MOLECULAR PHYSICS