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Chemical micro-sensor

Patent ·
OSTI ID:1175336
An integrated optical capillary electrophoresis system for analyzing an analyte. A modulated optical pump beam impinges on an capillary containing the analyte/buffer solution which is separated by electrophoresis. The thermally-induced change in the index of refraction of light in said electrophoresis capillary is monitored using an integrated micro-interferometer. The interferometer includes a first interferometer arm intersecting the electrophoresis capillary proximate the excitation beam and a second, reference interferometer arm. Changes in index of refraction in the analyte measured by interrogating the interferometer state using white light interferometry and a phase-generated carrier demodulation technique. Background thermo-optical activity in the buffer solution is cancelled by splitting the pump beam and exciting pure buffer solution in a second section of capillary where it crosses the reference arm of the interferometer.
Research Organization:
The Regents of the University of California, Oakland, CA (United States); Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
W-7405-ENG-48;
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
6,887,359
Application Number:
09/877,961
OSTI ID:
1175336
Country of Publication:
United States
Language:
English

References (12)

Optical-Phase-Shift Methods for Absorption Spectroscopy book January 1983
Differential refractometry by an integrated-optical Young interferometer journal March 1997
Hologram-based refractive index detector for capillary electrophoresis: separation of metal ions journal January 1994
Hologram-Based Thermooptical Absorbance Detection in Capillary Electrophoresis: Separation of Nucleosides and Nucleotides journal January 1995
Attomole amino acid determination by capillary zone electrophoresis with thermooptical absorbance detection journal January 1989
Trace detection in gases using phase fluctuation optical heterodyne spectroscopy journal April 1980
Electromanipulation and separation of cells using travelling electric fields journal August 1996
Trace analysis of water pollutants by photothermal phase shift spectroscopy with an integrated optical microinterferometer journal December 1996
Miniaturized photothermal sensors as analytical tools for detection of very small volumes in chemical process control journal February 1997
Thermooptical Technique for the Measurement of Absorption Loss Spectrum in Liquids journal January 1973
Phase fluctuation optical heterodyne spectroscopy of gases journal January 1981
Laser-Based Double-Beam Thermal Lens Detector for Microcolumn Liquid Chromatography journal August 1993

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