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Title: Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders

Patent ·
OSTI ID:1175285

Disclosed are novel nucleic acid and peptide compositions comprising methythlioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and idenification tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.

Research Organization:
Arch Development Corporation, Chicago, IL (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-86ER60408
Assignee:
Arch Development Corporation (Chicago, IL)
Patent Number(s):
6,870,037
Application Number:
08/674,311
OSTI ID:
1175285
Country of Publication:
United States
Language:
English

References (30)

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The use of methylthioadenosine phosphorylase activity to select for human chromosome 9 in interspecies and intraspecies hybrid cells journal September 1993
Analysis of tumor suppressor gene on human chromosome 9 in mouse x human somatic cell hybrids journal September 1994
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Cytogenetics of non-small cell lung cancer: Analysis of consistent non-random abnormalities journal July 1990
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 journal December 1993
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Germline p16 mutations in familial melanoma journal September 1994
Mapping a Putative Tumor Suppressor Gene on Chromosome 9 Bands p21-p22 with Microdissection Probes journal November 1994
Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia journal October 1992
REPORT on the Third International Workshop on Chromosome 9 journal July 1994
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Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias [see comments] journal December 1994
A method for screening arrayed cosmid libraries with mega insert yeast artificial chromosomes journal January 1995
Detection of 9p deletions in leukemia cell lines by interphase fluorescence in situ hybridization with YAC-derived probes journal August 1995
Dependence of adenine production upon polyamine synthesis in cultured human lymphoblasts journal July 1981
Genetic Alterations during Colorectal-Tumor Development journal September 1988
5′-Methylthioadenosine is the Major Source of Adenine in Human Cells book January 1984
5′-methylthioadenosine in urine from normal subjects and cancer patients journal November 1984
Disturbance in the metabolism of 5′-methylthioadenosine and adenine in patients with neoplastic diseases, and in those with a deficiency in adenine phosphoribosyltransferase journal September 1991
Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus journal September 1994
Codeletion of the genes for p16INK4, methylthioadenosine phosphorylase, interferon-α1, interferon-β1, and other 9p21 markers in human malignant cell lines journal January 1996
Sequential metabolism of 5′-isobutylthioadenosine by methylthioadenosine phosphorylase and purine-nucleoside phosphorylase in viable human cells journal February 1982
p53 allele losses, mutations and expression in breast cancer and their relationship to clinico-pathological parameters journal February 1992
Metabolism to methionine and growth stimulation by 5′-methylthioadenosine and 5′-methylthioinosine in mammalian cells journal April 1983
p16 gene homozygous deletions in acute lymphoblastic leukemia journal February 1995
A cell cycle regulator potentially involved in genesis of many tumor types journal April 1994
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers journal April 1994
5′-Methylthioadenosine Phosphorylase Deficiency in Malignant Cells: Recessive Expression of the Defective Phenotype in Intra-Species (Mouse X Mouse) Hybrids book January 1984

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60 APPLIED LIFE SCIENCES