skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Detection of biological molecules using chemical amplification and optical sensors

Abstract

Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

Inventors:
;
Publication Date:
Research Org.:
MiniMed, Inc., Sylmar, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175079
Patent Number(s):
6,804,544
Application Number:
09/934,390
Assignee:
MiniMed, Inc. (Sylmar, CA)
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Van Antwerp, William Peter, and Mastrototaro, John Joseph. Detection of biological molecules using chemical amplification and optical sensors. United States: N. p., 2004. Web.
Van Antwerp, William Peter, & Mastrototaro, John Joseph. Detection of biological molecules using chemical amplification and optical sensors. United States.
Van Antwerp, William Peter, and Mastrototaro, John Joseph. Tue . "Detection of biological molecules using chemical amplification and optical sensors". United States. https://www.osti.gov/servlets/purl/1175079.
@article{osti_1175079,
title = {Detection of biological molecules using chemical amplification and optical sensors},
author = {Van Antwerp, William Peter and Mastrototaro, John Joseph},
abstractNote = {Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {10}
}

Patent:

Save / Share:

Works referenced in this record:

Purification and partial characterization of a mitogenic lectin from vicia sativa
journal, March 1979

  • Falasca, A.; Franceschi, C.; Rossi, C. A.
  • Biochimica et Biophysica Acta (BBA) - Protein Structure, Vol. 577, Issue 1
  • DOI: 10.1016/0005-2795(79)90009-6

Aldehyde Syntheses. Study of the preparation of 9,10-anthracenedicarboxaldehyde
journal, December 1979

  • Lin, Yang-I; Lang, S. A.; Seifert, Christina M.
  • The Journal of Organic Chemistry, Vol. 44, Issue 25
  • DOI: 10.1021/jo00393a050

Molecular Fluorescence Sensor for Saccharides Based on Amino Coumarin
journal, February 1995

  • Sandanayake, K. R. A. Samankumara; Imazu, Sachiko; D. James, Tony
  • Chemistry Letters, Vol. 24, Issue 2
  • DOI: 10.1246/cl.1995.139

Fluorescent chemosensors of carbohydrates. A means of chemically communicating the binding of polyols in water based on chelation-enhanced quenching
journal, July 1992

  • Yoon, Juyoung; Czarnik, Anthony W.
  • Journal of the American Chemical Society, Vol. 114, Issue 14
  • DOI: 10.1021/ja00040a067

Quantitative determination of blood glucose using enzyme induced chemiluminescence of luminol
journal, March 1975

  • Bostick, Debra T.; Hercules, David M.
  • Analytical Chemistry, Vol. 47, Issue 3
  • DOI: 10.1021/ac60353a039

Development of the Implantable Glucose Sensor: What Are the Prospects and Why Is It Taking So Long?
journal, September 1995


Chiral discrimination of monosaccharides using a fluorescent molecular sensor
journal, March 1995

  • James, Tony D.; Samankumara Sandanayake, K. R. A.; Shinkai, Seiji
  • Nature, Vol. 374, Issue 6520
  • DOI: 10.1038/374345a0

Fluorescence lifetime-based sensing of pH, Ca2+, K+ and glucose
journal, March 1993


Sugar-Assisted Chirality Control of Tris(2,2′-bipyridine)-Metal Complexes
journal, July 1994


Microporous membrane flow cell with nonimmobilized enzyme for chemiluminescent determination of glucose
journal, September 1982

  • Pilosof, David.; Nieman, Timothy A.
  • Analytical Chemistry, Vol. 54, Issue 11
  • DOI: 10.1021/ac00248a010

Near-infrared spectroscopic measurement of glucose in a protein matrix
journal, November 1993

  • Marquardt, Lois A.; Arnold, Mark A.; Small, Gary W.
  • Analytical Chemistry, Vol. 65, Issue 22
  • DOI: 10.1021/ac00070a018

Homovanillic acid as a fluorometric substrate for oxidative enzymes. Analytical applications of the peroxidase, glucose oxidase, and xanthine oxidase systems
journal, January 1968

  • Guilbault, George G.; Brignac, Paul J.; Zimmer, Mary.
  • Analytical Chemistry, Vol. 40, Issue 1
  • DOI: 10.1021/ac60257a002

Novel Saccharide-Photoinduced Electron Transfer Sensors Based on the Interaction of Boronic Acid and Amine
journal, September 1995

  • James, Tony D.; Sandanayake, K. R. A. Samankumara; Iguchi, Ritsuko
  • Journal of the American Chemical Society, Vol. 117, Issue 35
  • DOI: 10.1021/ja00140a013