Tumor suppressor molecules and methods of use

Welch, Peter J.; Barber, Jack R.

Tumor suppressor molecules and methods of use

Patent · 07 September 2004

OSTI ID:1175018

Welch, Peter J.; Barber, Jack R.

The invention provides substantially pure tumor suppressor nucleic acid molecules and tumor suppressor polypeptides. The invention also provides hairpin ribozymes and antibodies selective for these tumor suppressor molecules. Also provided are methods of detecting a neoplastic cell in a sample using detectable agents specific for the tumor suppressor nucleic acids and polypeptides.

Research Organization:: Immusol, Inc., San Diego, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG03-98ER62624

Assignee:: Immusol, Inc. (San Diego, CA)

Patent Number(s):: 6,787,646

Application Number:: 09/438,917

OSTI ID:: 1175018

Country of Publication:: United States

Language:: English

References (11)

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Identification and Validation of a Gene Involved in Anchorage-Independent Cell Growth Control Using a Library of Randomized Hairpin Ribozymes Welch, Peter J.; Marcusson, Eric G.; Li, Qi-Xiang Genomics, Vol. 66, Issue 3 https://doi.org/10.1006/geno.2000.6230	journal	June 2000
Transforming growth factor alpha: mutation of aspartic acid 47 and leucine 48 results in different biological activities. Lazar, E.; Watanabe, S.; Dalton, S. Molecular and Cellular Biology, Vol. 8, Issue 3, p. 1247-1252 https://doi.org/10.1128/MCB.8.3.1247	journal	March 1988
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Events calendar No authors listed Membrane Technology, Vol. 1993, Issue 36, p. 12 https://doi.org/10.1016/0958-2118(93)90263-L	journal	April 1993
Identification of cDNAs for Sox-4, an HMG-Box Protein, and a Novel Human Homolog of Yeast Splicing Factor SSF-1 Differentially Regulated during Apoptosis Induced by Prostaglandin A2/Δ12-PGJ2 in Hep3B Cells Ahn, Sang-Gun; Cho, Gyeong-Ho; Jeong, Seong-Yun Biochemical and Biophysical Research Communications, Vol. 260, Issue 1 https://doi.org/10.1006/bbrc.1999.0856	journal	June 1999
Expression of a p16 ^INK4a -specific ribozyme downmodulates p16 ^INK4a abundance and accelerates cell proliferation Nylandsted, Jesper; Rohde, Mikkel; Bartek, Jiri FEBS Letters, Vol. 436, Issue 1 https://doi.org/10.1016/S0014-5793(98)01089-8	journal	September 1998
GenBank Benson, D. A.; Boguski, M. S.; Lipman, D. J. Nucleic Acids Research, Vol. 25, Issue 1 https://doi.org/10.1093/nar/25.1.1	journal	January 1997
Cloning and Characterization of peter pan , a Novel Drosophila Gene Required for Larval Growth Migeon, Jacques C.; Garfinkel, Michele S.; Edgar, Bruce A. Molecular Biology of the Cell, Vol. 10, Issue 6 https://doi.org/10.1091/mbc.10.6.1733	journal	June 1999

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