Metalloporphyrins and their uses as radiosensitizers for radiation therapy

Miura, Michiko; Slatkin, Daniel N.

Metalloporphyrins and their uses as radiosensitizers for radiation therapy

Patent · 06 July 2004

OSTI ID:1174934

Miura, Michiko; Slatkin, Daniel N.

The present invention covers radiosensitizers containing as an active ingredient halogenated derivatives of boronated porphyrins containing multiple carborane cages having the structure ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron--capture therapy and photodynamic therapy. The present invention also covers methods for using these radiosensitizers in tumor imaging and cancer treatment.

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-98CH10886

Assignee:: Brookhaven Science Associates, LLC (Upton, NY)

Patent Number(s):: 6,759,403

Application Number:: 10/117,010

OSTI ID:: 1174934

Country of Publication:: United States

Language:: English

References (10)

In vivo animal studies with gadolinium (III) texaphyrin as a radiation enhancer Miller, Richard A.; Woodburn, Kathryn; Fan, Qing International Journal of Radiation OncologyBiologyPhysics, Vol. 45, Issue 4 https://doi.org/10.1016/S0360-3016(99)00274-6	journal	November 1999
Evaluation of carborane-containing porphyrins as tumour targeting agents for boron neutron capture therapy. Miura, M.; Micca, P. L.; Fisher, C. D. The British Journal of Radiology, Vol. 71, Issue 847 https://doi.org/10.1259/bjr.71.847.9771389	journal	July 1998
Boron Neutron Capture Therapy for Glioblastoma Multiforme: Interim Results from the Phase I/II Dose-Escalation Studies Chanana, Arjun D.; Capala,, Jacek; Chadha, Manjeet Neurosurgery, Vol. 44, Issue 6 https://doi.org/10.1097/00006123-199906000-00013	journal	June 1999
A Straightforward Synthesis of 3,4-Difluoropyrrole Woller, Eric K.; Smirnov, Valeriy V.; DiMagno, Stephen G. The Journal of Organic Chemistry, Vol. 63, Issue 16 https://doi.org/10.1021/jo9805798	journal	August 1998
2,3,7,8,12,13,17,18-Octafluoro-5,10,15,20-tetraarylporphyrins and Their Zinc Complexes: First Spectroscopic, Electrochemical, and Structural Characterization of a Perfluorinated Tetraarylmetalloporphyrin Woller, Eric K.; DiMagno, Stephen G. The Journal of Organic Chemistry, Vol. 62, Issue 6 https://doi.org/10.1021/jo962159t	journal	March 1997
New Metalloporphyrins with Extremely Altered Redox Properties: Synthesis, Structure, and Facile Reduction to Air-Stable π-Anion Radicals of Zinc and Nickel β-Heptanitroporphyrins Ozette, Karine; Leduc, Philippe; Palacio, Magali Journal of the American Chemical Society, Vol. 119, Issue 27 https://doi.org/10.1021/ja970882a	journal	July 1997
Current status of 10B-neutron capture therapy: Enhancement of tumor dose via beam filtration and dose rate, and the effects of these parameters on minimum boron content: A theoretical evaluation Fairchild, R. G.; Bond, V. P. International Journal of Radiation OncologyBiologyPhysics, Vol. 11, Issue 4 https://doi.org/10.1016/0360-3016(85)90318-9	journal	April 1985
19F NMR Spectra and Structures of Halogenated Porphyrins Birnbaum, Eva R.; Hodge, Julia A.; Grinstaff, Mark W. Inorganic Chemistry, Vol. 34, Issue 14 https://doi.org/10.1021/ic00118a010	journal	July 1995
Are porphyrin mixtures favorable photodynamic anticancer drugs? A model study with combinatorial libraries of tetraphenylporphyrins Berlin, Kurt; Jain, Rishi K.; Richert, Clemens Biotechnology and Bioengineering, Vol. 61, Issue 2 https://doi.org/10.1002/(SICI)1097-0290(199821)61:2<107::AID-BIT5>3.0.CO;2-Q	journal	January 1998
Octabromotetraphenylporphyrin and its metal derivatives: Electronic structure and electrochemical properties Bhyrappa, P.; Krishnan, V. Inorganic Chemistry, Vol. 30, Issue 2 https://doi.org/10.1021/ic00002a018	journal	January 1991

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