Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Ion sensing method

Patent ·
OSTI ID:1174847
;
The present invention allows the determination of trace levels of ionic substances in a sample solution (ions, metal ions, and other electrically charged molecules) by coupling a separation method, such as liquid chromatography, with ion selective electrodes (ISE) prepared so as to allow detection at activities below 10.sup.-6 M. The separation method distributes constituent molecules into fractions due to unique chemical and physical properties, such as charge, hydrophobicity, specific binding interactions, or movement in an electrical field. The separated fractions are detected by means of the ISE(s). These ISEs can be used singly or in an array. Accordingly, modifications in the ISEs are used to permit detection of low activities, specifically, below 10.sup.-6 M, by using low activities of the primary analyte (the molecular species which is specifically detected) in the inner filling solution of the ISE. Arrays constructed in various ways allow flow-through sensing for multiple ions.
Research Organization:
IA INC, Ann Arbor, MI (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-00ER83019
Assignee:
IA INC (Ann Arbor, MI)
Patent Number(s):
6,736,958
Application Number:
09/836,542
OSTI ID:
1174847
Country of Publication:
United States
Language:
English

References (11)

Direct and replacement ion chromatography with potentiometric detection using a silver/silver bromide electrode journal January 1989
Lead-selective bulk optodes based on neutral ionophores with subnanomolar detection limits journal July 1992
Determination of monovalent cations by ion chromatography with ion-selective electrode detection journal October 1983
Lowering the Detection Limit of Solvent Polymeric Ion-Selective Electrodes. 1. Modeling the Influence of Steady-State Ion Fluxes journal March 1999
Nonlinear calibration of ion-selective electrode arrays for flow injection analysis journal August 1992
Replacement ion chromatography with potentiometric detection using a potassium-selective membrane electrode journal January 1989
Lowering the Detection Limit of Solvent Polymeric Ion-Selective Membrane Electrodes. 2. Influence of Composition of Sample and Internal Electrolyte Solution journal March 1999
Potentiometric detection of inorganic anions and cations in capillary electrophoresis with coated-wire ion-selective electrodes journal September 1997
Fast determination of anions by computerized ion chromatography coupled with selective detectors journal September 1981
Potentiometric pH detection in suppressed ion chromatography journal April 1989
Potentiometric detection in ion chromatography using multi-ionophore membrane electrodes journal October 1993

Similar Records

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY