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Functionalized active-nucleus complex sensor

Patent ·
OSTI ID:1174596
; ; ;
A functionalized active-nucleus complex sensor that selectively associates with one or more target species, and a method for assaying and screening for one or a plurality of target species utilizing one or a plurality of functionalized active-nucleus complexes with at least two of the functionalized active-nucleus complexes having an attraction affinity to different corresponding target species. The functionalized active-nucleus complex has an active-nucleus and a targeting carrier. The method involves functionalizing an active-nucleus, for each functionalized active-nucleus complex, by incorporating the active-nucleus into a macromolucular or molecular complex that is capable of binding one of the target species and then bringing the macromolecular or molecular complexes into contact with the target species and detecting the occurrence of or change in a nuclear magnetic resonance signal from each of the active-nuclei in each of the functionalized active-nucleus complexes.
Research Organization:
The Regents of the University of California, Oakland, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC03-76SF00098
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
6,652,833
Application Number:
09/903,279
OSTI ID:
1174596
Country of Publication:
United States
Language:
English

References (8)

Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides: DETERMINANTS OF SPECIFICITY AND UTILITY IN ASSAYS OF RECEPTOR FUNCTION journal April 2000
Relaxation Processes in a System of Two Spins journal July 1955
Two Modes of Ligand Binding in Maltose-binding Protein of Escherichia coli: CORRELATION WITH THE STRUCTURE OF LIGANDS AND THE STRUCTURE OF BINDING PROTEIN journal July 1997
High-field cross polarization NMR from laser-polarized xenon to a polymer surface journal September 1993
Multi-planar image formation using NMR spin echoes journal February 1977
129 Xe and 1 H NMR Study of the Reversible Trapping of Xenon by Cryptophane-A in Organic Solution journal February 1998
FLASH imaging. Rapid NMR imaging using low flip-angle pulses journal April 1986
High-field NMR of adsorbed xenon polarized by laser pumping journal February 1991

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