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Interrogation cradle and insertable containment fixture for detecting birefringent microcrystals in bile

Patent ·
OSTI ID:1174517

A transparent flow channel fluidly communicates a fluid source and a collection reservoir. An interrogating light beam passes through a first polarizer having a first plane of polarization. The flow channel is orthogonal to the light beam. The light beam passes through a fluid sample as it flows through the flow channel, and is then filtered through a second polarizer having a second plane of polarization rotated 90.degree. from the first plane of polarization. An electronic photo-detector is aligned with the light beam, and signals the presence of birefringent microcrystals in the fluid sample by generating voltage pulses. A disposable containment fixture includes the flow channel and the collection reservoir. The fixture is adapted for removable insertion into an interrogation cradle that includes optical and data processing components. The cradle rigidly positions the centerline of the flow channel orthogonal to the light beam.

Research Organization:
The Regents of the University of California, Oakland, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
W-7405-ENG-48
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
6,628,387
Application Number:
09/815,082
OSTI ID:
1174517
Country of Publication:
United States
Language:
English

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