Method for calibrating a Fourier transform ion cyclotron resonance mass spectrometer

Patent · 19 August 2003

OSTI ID:1174454

Smith, Richard D.; Masselon, Christophe D.; Tolmachev, Aleksey

A method for improving the calibration of a Fourier transform ion cyclotron resonance mass spectrometer wherein the frequency spectrum of a sample has been measured and the frequency (f) and intensity (I) of at least three species having known mass to charge (m/z) ratios and one specie having an unknown (m/z) ratio have been identified. The method uses the known (m/z) ratios, frequencies, and intensities at least three species to calculate coefficients A, B, and C, wherein the mass to charge ratio of a least one of the three species (m/z).sub.i is equal to ##EQU1## wherein f.sub.i is the detected frequency of the specie, G(I.sub.i) is a predetermined function of the intensity of the species, and Q is a predetermined exponent. Using the calculated values for A, B, and C, the mass to charge ratio of the unknown specie (m/z).sub.ii is calculated as the sum of ##EQU2## wherein f.sub.ii is the measured frequency of the unknown specie, and (I.sub.ii) is the measured intensity of the unknown specie.

• Research Organization: ~Individually Owned Patent
• Sponsoring Organization: USDOE
• DOE Contract Number: AC06-76RL01830
• Assignee: Smith, Richard D.; Masselon, Christophe D.; Tolmachev, Aleksey
• Patent Number(s): 6,608,302
• Application Number: 09/870,577
• OSTI ID: 1174454
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY