Identification of cancer protein biomarkers using proteomic techniques

Mor, Gil G; Ward, David C; Bray-Ward, Patricia

Identification of cancer protein biomarkers using proteomic techniques

Patent · 10 March 2015

OSTI ID:1172149

Mor, Gil G; Ward, David C; Bray-Ward, Patricia

The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein. The biomarkers identified herein can also be used in the prognosis and monitoring of cancer. The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer.

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Research Organization:: Yale University, New Haven, CT (United States)

Sponsoring Organization:: USDOE

Assignee:: Yale University (New Haven, CT)

Patent Number(s):: 8,975,379

Application Number:: 12/644,677

OSTI ID:: 1172149

Country of Publication:: United States

Language:: English

References (49)

No association between serum levels of insulin-like growth factor-I, vascular endothelial growth factor, prolactin and clinicopathological characteristics of breast carcinoma after surgery: Serum levels and breast cancer Sancak, B.; Coskun, U.; Gunel, N. Internal Medicine Journal, Vol. 34, Issue 6 https://doi.org/10.1111/j.1444-0903.2004.00591.x	journal	June 2004
Preoperative Sensitivity and Specificity for Early-Stage Ovarian Cancer When Combining Cancer Antigen CA-125II, CA 15-3, CA 72-4, and Macrophage Colony-Stimulating Factor Using Mixtures of Multivariate Normal Distributions Skates, Steven J.; Horick, Nora; Yu, Yinhua Journal of Clinical Oncology, Vol. 22, Issue 20 https://doi.org/10.1200/JCO.2004.03.091	journal	October 2004
Obesity, adipocytokines, and insulin resistance in breast cancer Rose, D. P.; Komninou, D.; Stephenson, G. D. Obesity Reviews, Vol. 5, Issue 3 https://doi.org/10.1111/j.1467-789X.2004.00142.x	journal	August 2004
Growth Factor Signaling Induces Metastasis Genes in Transformed Cells: Molecular Connection between Akt Kinase and Osteopontin in Breast Cancer Zhang, G.; He, B.; Weber, G. F. Molecular and Cellular Biology, Vol. 23, Issue 18 https://doi.org/10.1128/MCB.23.18.6507-6519.2003	journal	August 2003
Serum tumor markers in colorectal cancer staging, grading, and follow-up Plebani, Mario; De Paoli, Massimo; Basso, Daniela Journal of Surgical Oncology, Vol. 62, Issue 4, p. 239-244 https://doi.org/10.1002/(SICI)1096-9098(199608)62:4<239::AID-JSO2>3.0.CO;2-7	journal	August 1996
Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells Dixit, Vishwa Deep; Schaffer, Eric M.; Pyle, Robert S. Journal of Clinical Investigation, Vol. 114, Issue 1 https://doi.org/10.1172/JCI200421134	journal	July 2004
Multiplexed protein profiling on microarrays by rolling-circle amplification Schweitzer, Barry; Roberts, Scott; Grimwade, Brian Nature Biotechnology, Vol. 20, Issue 4, p. 359-365 https://doi.org/10.1038/nbt0402-359	journal	April 2002
Three Biomarkers Identified from Serum Proteomic Analysis for the Detection of Early Stage Ovarian Cancer Zhang, Zhen; Bast, Robert C.; Yu, Yinhua Cancer Research, Vol. 64, Issue 16 https://doi.org/10.1158/0008-5472.CAN-04-0746	journal	August 2004
The metastasis gene osteopontin: a candidate target for cancer therapy Weber, Georg F. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Vol. 1552, Issue 2 https://doi.org/10.1016/S0304-419X(01)00037-3	journal	December 2001
Plasma Prolactin Concentrations and Risk of Postmenopausal Breast Cancer Tworoger, Shelley S.; Eliassen, A. Heather; Rosner, Bernard Cancer Research, Vol. 64, Issue 18 https://doi.org/10.1158/0008-5472.CAN-04-1870	journal	September 2004
The role of Osteopontin in tumor metastasis Wai, Philip Y.; Kuo, Paul C. Journal of Surgical Research, Vol. 121, Issue 2, p. 228-241 https://doi.org/10.1016/j.jss.2004.03.028	journal	October 2004
Downregulation of long-form prolactin receptor mRNA during prolactin-induced luteal regression Bowen, Jm; Telleria, Cm; Towns, R. European Journal of Endocrinology https://doi.org/10.1530/eje.0.1430285	journal	August 2000
Leptin expression in colorectal and breast cancer patients. Tessitore, L.; Vizio, B.; Jenkins, O. International Journal of Molecular Medicine https://doi.org/10.3892/ijmm.5.4.421	journal	April 2000
Elevated Serum Insulin-Like Growth Factor Binding Protein-2 as a Prognostic Marker in Patients with Ovarian Cancer Baron-Hay, S. Clinical Cancer Research, Vol. 10, Issue 5 https://doi.org/10.1158/1078-0432.CCR-0672-2	journal	March 2004
Leptin and prolactin modulate the expression of SOCS-1 in association with interleukin-6 and tumor necrosis factor-α in mammary cells: a role in differentiated secretory epithelium Motta, M.; Accornero, P.; Baratta, M. Regulatory Peptides, Vol. 121, Issue 1-3, p. 163-170 https://doi.org/10.1016/j.regpep.2004.05.002	journal	September 2004
Circulating levels of insulin-like growth factor-II and IGF-binding protein 3 in cervical cancer Mathur, Subbi P.; Mathur, Rajesh S.; Underwood, Paul B. Gynecologic Oncology, Vol. 91, Issue 3, p. 486-493 https://doi.org/10.1016/j.ygyno.2003.08.023	journal	December 2003
Utility of osteopontin as a biomarker in recurrent epithelial ovarian cancer Brakora, K.; Lee, H.; Yusuf, R. Gynecologic Oncology, Vol. 93, Issue 2 https://doi.org/10.1016/j.ygyno.2004.01.050	journal	May 2004
Differential Gene Expression in Chemically Induced Mouse Lung Adenomas Yao, Ruisheng; Wang, Yian; Lubet, Ronald A. Neoplasia, Vol. 5, Issue 1, p. 41-52 https://doi.org/10.1016/S1476-5586(03)80016-7	journal	January 2003
Use of Proteomic Patterns in Serum to Identify Ovarian Cancer Petricoin, Emanuel F.; Ardekani, Ali M.; Hitt, Ben A. Obstetrical & Gynecological Survey, Vol. 57, Issue 6 https://doi.org/10.1097/00006254-200206000-00015	journal	January 2002
Ovarian cancer screening Menon, U. Canadian Medical Association Journal, Vol. 171, Issue 4 https://doi.org/10.1503/cmaj.1031298	journal	August 2004
Prolactin increases HO-1 expression and induces VEGF production in human macrophages Malaguarnera, L.; Imbesi, R. M.; Scuto, A. Journal of Cellular Biochemistry, Vol. 93, Issue 1 https://doi.org/10.1002/jcb.20167	journal	January 2004
Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: Identification of candidate molecular markers for ovarian cancer diagnosis and therapy Santin, Alessandro D.; Zhan, Fenghuang; Bellone, Stefania International Journal of Cancer, Vol. 112, Issue 1 https://doi.org/10.1002/ijc.20408	journal	August 2004
Evaluation of osteopontin as biomarker for pancreatic adenocarcinoma Koopmann, Jens; Fedarko, Neal S.; Jain, Alka Gastroenterology, Vol. 124, Issue 4, A441 https://doi.org/10.1016/S0016-5085(03)82230-8	journal	April 2003
Use of serum prolactin for monitoring the therapeutic response in ovarian malignancy Jha, P.; Farooq, A.; Rao, D. L. International Journal of Gynecology & Obstetrics, Vol. 36, Issue 1, p. 33-38 https://doi.org/10.1016/0020-7292(91)90175-5	journal	September 1991
Combining CA 125 and SMR serum markers for diagnosis and early detection of ovarian carcinoma McIntosh, M. W.; Drescher, C.; Karlan, B. Gynecologic Oncology, Vol. 95, Issue 1, p. 9-15 https://doi.org/10.1016/j.ygyno.2004.07.039	journal	October 2004
Role of osteopontin in tumour progression Rittling, S. R.; Chambers, A. F. British Journal of Cancer, Vol. 90, Issue 10 https://doi.org/10.1038/sj.bjc.6601839	journal	April 2004
Osteopontin is a potential target gene in mouse mammary cancer chemoprevention by Se-methylselenocysteine Unni, Emmanual; Kittrell, Frances S.; Singh, Uma Breast Cancer Research, Vol. 6, Issue 5 https://doi.org/10.1186/bcr914	journal	July 2004
Multiple Kinase Cascades Mediate Prolactin Signals to Activating Protein-1 in Breast Cancer Cells Gutzman, Jennifer H.; Rugowski, Debra E.; Schroeder, Matthew D. Molecular Endocrinology, Vol. 18, Issue 12 https://doi.org/10.1210/me.2004-0187	journal	December 2004
Ovarian cancer screening Urban, Nicole; McIntosh, Martin W.; Andersen, Marin (Robyn) Hematology/Oncology Clinics of North America, Vol. 17, Issue 4, p. 989-1005 https://doi.org/10.1016/S0889-8588(03)00063-7	journal	August 2003
The Functional and Clinical Roles of Osteopontin in Cancer and Metastasis No authors listed Current Molecular Medicine, Vol. 1, Issue 5 https://doi.org/10.2174/1566524013363339	journal	November 2001
Osteopontin as an Adjunct to CA125 in Detecting Recurrent Ovarian Cancer Schorge, J. O. Clinical Cancer Research, Vol. 10, Issue 10 https://doi.org/10.1158/1078-0432.CCR-03-0365	journal	May 2004
Ovarian dysgerminoma showing high serum levels and positive immunostaining of placental alkaline phosphatase and neuron-specific enolase associated with elevation of serum prolactin level Yoshida, Masumi; Koshiyama, Masafumi; Konishi, Mitsunaga European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol. 81, Issue 1, p. 123-128 https://doi.org/10.1016/S0301-2115(98)00162-6	journal	October 1998
Serum Vascular Endothelial Growth Factor and Serum Leptin in Patients with Cervical Cancer Lebrecht, Antje; Ludwig, Elisabeth; Huber, Ambros Gynecologic Oncology, Vol. 85, Issue 1 https://doi.org/10.1006/gyno.2001.6517	journal	April 2002
Progress and Challenges in Screening for Early Detection of Ovarian Cancer Jacobs, Ian J.; Menon, Usha Molecular & Cellular Proteomics, Vol. 3, Issue 4 https://doi.org/10.1074/mcp.R400006-MCP200	journal	February 2004
Serum protein markers for early detection of ovarian cancer Mor, G.; Visintin, I.; Lai, Y. Proceedings of the National Academy of Sciences, Vol. 102, Issue 21, p. 7677-7682 https://doi.org/10.1073/pnas.0502178102	journal	May 2005
Fasting Ghrelin Levels in Physically Active Women: Relationship with Menstrual Disturbances and Metabolic Hormones De Souza, Mary Jane; Leidy, Heather J.; O’Donnell, Emma The Journal of Clinical Endocrinology & Metabolism, Vol. 89, Issue 7 https://doi.org/10.1210/jc.2003-032007	journal	July 2004
Enhanced Expression of Leptin and Leptin Receptor (OB-R) in Human Breast Cancer Ishikawa, Makoto; Kitayama, Joji; Nagawa, Hirokazu Clinical Cancer Research, Vol. 10, Issue 13 https://doi.org/10.1158/1078-0432.CCR-03-0749	journal	July 2004
Multiplexed Immunobead-Based Cytokine Profiling for Early Detection of Ovarian Cancer Gorelik, E. Cancer Epidemiology Biomarkers & Prevention, Vol. 14, Issue 4 https://doi.org/10.1158/1055-9965.EPI-04-0404	journal	April 2005
Osteopontin as a Potential Diagnostic Biomarker for Ovarian Cancer Kim, Jae-Hoon; Skates, Steven J.; Uede, Toshimitsu JAMA, Vol. 287, Issue 13, p. 1671-1679 https://doi.org/10.1001/jama.287.13.1671	journal	April 2002
Expression of Leptin Receptors and Potential Effects of Leptin on the Cell Growth and Activation of Mitogen-Activated Protein Kinases in Ovarian Cancer Cells Choi, Jung-Hye; Park, Se-Hyung; Leung, Peter C. K. The Journal of Clinical Endocrinology & Metabolism, Vol. 90, Issue 1 https://doi.org/10.1210/jc.2004-0297	journal	January 2005
Prolactin acts as a potent survival factor for human breast cancer cell lines Perks, C. M.; Keith, A. J.; Goodhew, K. L. British Journal of Cancer, Vol. 91, Issue 2 https://doi.org/10.1038/sj.bjc.6601947	journal	June 2004
Cancer screening in a high risk population: a clinical trial Taylor, Kenneth J. W.; Schwartz, Peter E. Ultrasound in Medicine & Biology, Vol. 27, Issue 4, p. 461-466 https://doi.org/10.1016/S0301-5629(00)00359-8	journal	April 2001
Selection of Potential Markers for Epithelial Ovarian Cancer with Gene Expression Arrays and Recursive Descent Partition Analysis Lu, K. H. Clinical Cancer Research, Vol. 10, Issue 10 https://doi.org/10.1158/1078-0432.CCR-03-0409	journal	May 2004
Diagnostic Markers for Early Detection of Ovarian Cancer Visintin, I.; Feng, Z.; Longton, G. Clinical Cancer Research, Vol. 14, Issue 4 https://doi.org/10.1158/1078-0432.CCR-07-1569	journal	February 2008
Prolactin as a tumour marker in cancer of the cervix G. Perumal, J. Moodley, R. J. Pegor, B. Journal of Obstetrics and Gynaecology, Vol. 18, Issue 3 https://doi.org/10.1080/01443619867452	journal	January 1998
Leptin directly stimulates aromatase activity in human luteinized granulosa cells Kitawaki, J. Molecular Human Reproduction, Vol. 5, Issue 8 https://doi.org/10.1093/molehr/5.8.708	journal	August 1999
Therapeutic Implications of Immune-endocrine Interactions in the Critically Ill Patients Oberbeck, Reiner Current Drug Targets - Immune, Endocrine & Metabolic Disorders, Vol. 4, Issue 2 https://doi.org/10.2174/1568008043339884	journal	June 2004
Insulin-Like Growth Factor (IGF)-I and IGF-II Serum Concentrations in Patients with Benign and Malignant Breast Lesions: Free IGF-II Is Correlated with Breast Cancer Size Singer, C. F. Clinical Cancer Research, Vol. 10, Issue 12 https://doi.org/10.1158/1078-0432.CCR-03-0093	journal	June 2004
Elevation of Multiple Serum Markers in Patients With Stage I Ovarian Cancer Woolas, R. P.; Xu, F. -J.; Jacabs, I. J. JNCI Journal of the National Cancer Institute, Vol. 85, Issue 21 https://doi.org/10.1093/jnci/85.21.1748	journal	November 1993

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