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Title: Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual

Abstract

A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source.

Inventors:
; ; ;
Publication Date:
Research Org.:
Idaho National Lab. (INL), Idaho Falls, ID (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1171695
Patent Number(s):
8,969,009
Application Number:
12/586,109
Assignee:
IDO
DOE Contract Number:  
AC07-05ID14517
Resource Type:
Patent
Resource Relation:
Patent File Date: 2009 Sep 17
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Thompson, Vicki S, Lacey, Jeffrey A, Gentillon, Cynthia A, and Apel, William A. Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual. United States: N. p., 2015. Web.
Thompson, Vicki S, Lacey, Jeffrey A, Gentillon, Cynthia A, & Apel, William A. Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual. United States.
Thompson, Vicki S, Lacey, Jeffrey A, Gentillon, Cynthia A, and Apel, William A. Tue . "Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual". United States. doi:. https://www.osti.gov/servlets/purl/1171695.
@article{osti_1171695,
title = {Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual},
author = {Thompson, Vicki S and Lacey, Jeffrey A and Gentillon, Cynthia A and Apel, William A},
abstractNote = {A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 03 00:00:00 EST 2015},
month = {Tue Mar 03 00:00:00 EST 2015}
}

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