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Title: Structural and Kinetic Basis of Steroid 17[alpha],20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2

Journal Article · · J. Biol. Chem.
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  1. NWU
+ Show Author Affiliations

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
National Institutes of Health (NIH)
OSTI ID:
1170036
Journal Information:
J. Biol. Chem., Vol. 290, Issue (6) ; 02, 2015
Country of Publication:
United States
Language:
ENGLISH
Citation Metrics:
Cited by: 48 works
Citation information provided by
Web of Science

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Cited By (8)

Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency journal April 2018
Genetic Disruption of 21-Hydroxylase in Zebrafish Causes Interrenal Hyperplasia journal September 2017
Conformational selection dominates binding of steroids to human cytochrome P450 17A1 journal June 2019
In Situ Proteolysis for Crystallization of Membrane Bound Cytochrome P450 17A1 and 17A2 Proteins from Zebrafish journal April 2016
The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function journal February 2016
Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish journal April 2018
Protein Engineering of the Progesterone Hydroxylating P450-Monooxygenase CYP17A1 Alters Its Regioselectivity journal August 2018
Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency text January 2018

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