Methods for isolation and viability assessment of biological organisms

Letant, Sonia Edith; Baker, Sarah Elyse; Bond, Tiziana; Chang, Allan Shih-Ping

Methods for isolation and viability assessment of biological organisms

Patent · 03 February 2015

OSTI ID:1169062

Letant, Sonia Edith; Baker, Sarah Elyse; Bond, Tiziana; Chang, Allan Shih-Ping

Isolation of biological or chemical organisms can be accomplished using a surface enhanced Raman scattering (SERS) system. The SERS system can be a single or a stacked plurality of photonic crystal membranes with noble-metal lined through pores for flowing analyte potentially containing the biological or chemical organisms. The through pores can be adapted to trap individual biological or chemical organisms and emit SERS spectra, which can then be detected by a detector and further analyzed for viability of the biological or chemical organism.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-07NA27344

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Number(s):: 8,947,657

Application Number:: 13/117,079

OSTI ID:: 1169062

Country of Publication:: United States

Language:: English

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Sampled-grating DBR laser-based analog optical transmitters Johansson, L. A.; Getty, J. T.; Akulova, Y. A. Journal of Lightwave Technology, Vol. 21, Issue 12 https://doi.org/10.1109/JLT.2003.819786	journal	December 2003
Surface-Based Gold-Nanoparticle Sensor for Specific and Quantitative DNA Hybridization Detection Olofsson, Linda; Rindzevicius, Tomas; Pfeiffer, Indriati Langmuir, Vol. 19, Issue 24 https://doi.org/10.1021/la0352927	journal	November 2003
Rapid and Sensitive Detection of Respiratory Virus Molecular Signatures Using a Silver Nanorod Array SERS Substrate Shanmukh, Saratchandra; Jones, Les; Driskell, Jeremy Nano Letters, Vol. 6, Issue 11 https://doi.org/10.1021/nl061666f	journal	November 2006
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Enzyme Immobilization on Porous Silicon Surfaces Létant, S. E.; Hart, B. R.; Kane, S. R. Advanced Materials, Vol. 16, Issue 8, p. 689-693 https://doi.org/10.1002/adma.200306173	journal	February 2004
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Specific detection of proteins using photonic crystal waveguides Buswell, S. C.; Wright, V. A.; Buriak, J. M. Optics Express, Vol. 16, Issue 20 https://doi.org/10.1364/OE.16.015949	journal	January 2008
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Rapidly reconfigurable all-optical universal logic gates Goddard, Lynford L.; Kallman, Jeffrey S.; Bond, Tiziana C. Optics East 2006 https://doi.org/10.1117/12.686169	conference	October 2006
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Remote surface enhanced Raman spectroscopy imaging via a nanostructured optical fiber bundle Guieu, Valérie; Garrigue, Patrick; Lagugné-Labarthet, François Optics Express, Vol. 17, Issue 26 https://doi.org/10.1364/OE.17.024030	journal	January 2009
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