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Title: Metal ion and ligand binding of integrin [alpha subscript 5 beta subscript 1]

Authors:
;  [1]
  1. BCH
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1168483
Resource Type:
Journal Article
Journal Name:
Proc. Natl. Acad. Sci. USA
Additional Journal Information:
Journal Volume: 111; Journal Issue: (50) ; 12, 2014
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Xia, Wei, Springer, Timothy A., and Harvard-Med). Metal ion and ligand binding of integrin [alpha subscript 5 beta subscript 1]. United States: N. p., 2018. Web. doi:10.1073/pnas.1420645111.
Xia, Wei, Springer, Timothy A., & Harvard-Med). Metal ion and ligand binding of integrin [alpha subscript 5 beta subscript 1]. United States. doi:10.1073/pnas.1420645111.
Xia, Wei, Springer, Timothy A., and Harvard-Med). Fri . "Metal ion and ligand binding of integrin [alpha subscript 5 beta subscript 1]". United States. doi:10.1073/pnas.1420645111.
@article{osti_1168483,
title = {Metal ion and ligand binding of integrin [alpha subscript 5 beta subscript 1]},
author = {Xia, Wei and Springer, Timothy A. and Harvard-Med)},
abstractNote = {},
doi = {10.1073/pnas.1420645111},
journal = {Proc. Natl. Acad. Sci. USA},
number = (50) ; 12, 2014,
volume = 111,
place = {United States},
year = {2018},
month = {3}
}

Works referenced in this record:

α V β 3 Integrin Crystal Structures and Their Functional Implications
journal, October 2012

  • Dong, Xianchi; Mi, Li-Zhi; Zhu, Jianghai
  • Biochemistry, Vol. 51, Issue 44
  • DOI: 10.1021/bi300734n

Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin α IIb β 3
journal, August 2008

  • Springer, Timothy A.; Zhu, Jianghai; Xiao, Tsan
  • The Journal of Cell Biology, Vol. 182, Issue 4
  • DOI: 10.1083/jcb.200801146

The Crystal Structure of the Plexin-Semaphorin-Integrin Domain/Hybrid Domain/I-EGF1 Segment from the Human Integrin β 2 Subunit at 1.8-Å Resolution
journal, June 2005

  • Shi, MinLong; Sundramurthy, Kumar; Liu, Bin
  • Journal of Biological Chemistry, Vol. 280, Issue 34
  • DOI: 10.1074/jbc.M502525200

Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
journal, September 2004

  • Xiao, Tsan; Takagi, Junichi; Coller, Barry S.
  • Nature, Vol. 432, Issue 7013
  • DOI: 10.1038/nature02976

Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster
journal, November 2003

  • Chen, JianFeng; Salas, Azucena; Springer, Timothy A.
  • Nature Structural & Molecular Biology, Vol. 10, Issue 12
  • DOI: 10.1038/nsb1011

Structural specializations of α 4 β 7 , an integrin that mediates rolling adhesion
journal, January 2012

  • Yu, Yamei; Zhu, Jianghai; Mi, Li-Zhi
  • The Journal of Cell Biology, Vol. 196, Issue 1
  • DOI: 10.1083/jcb.201110023

Simulation of Diffusion Time of Small Molecules in Protein Crystals
journal, March 2006


Molecular Basis of Ligand Recognition by Integrin α 5 β 1 : II. SPECIFICITY OF Arg-Gly-Asp BINDING IS DETERMINED BY Trp
journal, April 2000

  • Humphries, Jonathan D.; Askari, Janet A.; Zhang, Xi-Ping
  • Journal of Biological Chemistry, Vol. 275, Issue 27
  • DOI: 10.1074/jbc.M000568200

Aromatic-aromatic interaction: a mechanism of protein structure stabilization
journal, July 1985


Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
journal, May 1984

  • Pierschbacher, Michael D.; Ruoslahti, Erkki
  • Nature, Vol. 309, Issue 5963
  • DOI: 10.1038/309030a0

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor
journal, March 2012

  • Nagae, Masamichi; Re, Suyong; Mihara, Emiko
  • The Journal of Cell Biology, Vol. 197, Issue 1
  • DOI: 10.1083/jcb.201111077

Integrin Activation Involves a Conformational Change in the α1 Helix of the β Subunit A-domain
journal, March 2002

  • Mould, A. Paul; Askari, Janet A.; Barton, Stephanie
  • Journal of Biological Chemistry, Vol. 277, Issue 22
  • DOI: 10.1074/jbc.M201571200

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)
journal, February 1995


Role of ADMIDAS Cation-binding Site in Ligand Recognition by Integrin α 5 β 1
journal, October 2003

  • Mould, A. Paul; Barton, Stephanie J.; Askari, Janet A.
  • Journal of Biological Chemistry, Vol. 278, Issue 51
  • DOI: 10.1074/jbc.M306655200

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces
journal, December 2008


Complete integrin headpiece opening in eight steps
journal, June 2013

  • Zhu, Jieqing; Zhu, Jianghai; Springer, Timothy A.
  • The Journal of Cell Biology, Vol. 201, Issue 7
  • DOI: 10.1083/jcb.201212037

A Structural Hypothesis for the Transition between Bent and Extended Conformations of the Leukocyte β2 Integrins
journal, August 2007

  • Shi, MinLong; Foo, Shen Yun; Tan, Suet-Mien
  • Journal of Biological Chemistry, Vol. 282, Issue 41
  • DOI: 10.1074/jbc.M701670200

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

Orbital shaker technology for the cultivation of mammalian cells in suspension
journal, January 2005

  • Muller, Natalie; Girard, Philippe; Hacker, David L.
  • Biotechnology and Bioengineering, Vol. 89, Issue 4
  • DOI: 10.1002/bit.20358

Structural basis for selectin mechanochemistry
journal, December 2008


Golgi Bypass: Skirting Around the Heart of Classical Secretion
journal, March 2011


Activation of Leukocyte β2 Integrins by Conversion from Bent to Extended Conformations
journal, October 2006


Structure of an integrin with an αI domain, complement receptor type 4
journal, December 2009


PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

How Natalizumab Binds and Antagonizes α 4 Integrins
journal, September 2013

  • Yu, Yamei; Schürpf, Thomas; Springer, Timothy A.
  • Journal of Biological Chemistry, Vol. 288, Issue 45
  • DOI: 10.1074/jbc.M113.501668

Divalent cation regulation of the function of the leukocyte integrin LFA-1
journal, January 1992


Allosteric β 1 Integrin Antibodies That Stabilize the Low Affinity State by Preventing the Swing-out of the Hybrid Domain
journal, April 2004

  • Luo, Bing-Hao; Strokovich, Konstantin; Walz, Thomas
  • Journal of Biological Chemistry, Vol. 279, Issue 26
  • DOI: 10.1074/jbc.M404354200

The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3
journal, April 2009


Phage Libraries Displaying Cyclic Peptides with Different Ring Sizes: Ligand Specificities of the RGD-Directed Integrins
journal, March 1995

  • Koivunen, Erkki; Wang, Bingcheng; Ruoslahti, Erkki
  • Nature Biotechnology, Vol. 13, Issue 3
  • DOI: 10.1038/nbt0395-265

Integrin inside-out signaling and the immunological synapse
journal, February 2012


Geometry of metal–ligand interactions in proteins
journal, March 2001

  • Harding, Marjorie M.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 57, Issue 3
  • DOI: 10.1107/S0907444900019168

Analysis of protein-ligand interactions by fluorescence polarization
journal, March 2011


Structure-Guided Design of a High-Affinity Platelet Integrin  IIb 3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
journal, March 2012


The ensemble nature of allostery
journal, April 2014

  • Motlagh, Hesam N.; Wrabl, James O.; Li, Jing
  • Nature, Vol. 508, Issue 7496
  • DOI: 10.1038/nature13001

Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening
journal, December 2010


The Role of the CPNKEKEC Sequence in the β 2 Subunit I Domain in Regulation of Integrin α L β 2 (LFA-1)
journal, March 2002


A Novel Adaptation of the Integrin PSI Domain Revealed from Its Crystal Structure
journal, August 2004

  • Xiong, Jian-Ping; Stehle, Thilo; Goodman, Simon L.
  • Journal of Biological Chemistry, Vol. 279, Issue 39
  • DOI: 10.1074/jbc.C400362200

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants
journal, December 1993


An internal ligand-bound, metastable state of a leukocyte integrin, α X β 2
journal, November 2013

  • Sen, Mehmet; Yuki, Koichi; Springer, Timothy A.
  • The Journal of Cell Biology, Vol. 203, Issue 4
  • DOI: 10.1083/jcb.201308083