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Title: Dielectrokinetic chromatography devices

Abstract

Disclosed herein are methods and devices for dielectrokinetic chromatography. As disclosed, the devices comprise microchannels having at least one perturber which produces a non-uniformity in a field spanning the width of the microchannel. The interaction of the field non-uniformity with a perturber produces a secondary flow which competes with a primary flow. By decreasing the size of the perturber the secondary flow becomes significant for particles/analytes in the nanometer-size range. Depending on the nature of a particle/analyte present in the fluid and its interaction with the primary flow and the secondary flow, the analyte may be retained or redirected. The composition of the primary flow can be varied to affect the magnitude of primary and/or secondary flows on the particles/analytes and thereby separate and concentrate it from other particles/analytes.

Inventors:
; ;
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1165448
Patent Number(s):
8,911,606
Application Number:
14/050,502
Assignee:
Sandia Corporation (Albuquerque, NM)
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 Oct 10
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Chirica, Gabriela S, Fiechtner, Gregory J, and Singh, Anup K. Dielectrokinetic chromatography devices. United States: N. p., 2014. Web.
Chirica, Gabriela S, Fiechtner, Gregory J, & Singh, Anup K. Dielectrokinetic chromatography devices. United States.
Chirica, Gabriela S, Fiechtner, Gregory J, and Singh, Anup K. Tue . "Dielectrokinetic chromatography devices". United States. https://www.osti.gov/servlets/purl/1165448.
@article{osti_1165448,
title = {Dielectrokinetic chromatography devices},
author = {Chirica, Gabriela S and Fiechtner, Gregory J and Singh, Anup K},
abstractNote = {Disclosed herein are methods and devices for dielectrokinetic chromatography. As disclosed, the devices comprise microchannels having at least one perturber which produces a non-uniformity in a field spanning the width of the microchannel. The interaction of the field non-uniformity with a perturber produces a secondary flow which competes with a primary flow. By decreasing the size of the perturber the secondary flow becomes significant for particles/analytes in the nanometer-size range. Depending on the nature of a particle/analyte present in the fluid and its interaction with the primary flow and the secondary flow, the analyte may be retained or redirected. The composition of the primary flow can be varied to affect the magnitude of primary and/or secondary flows on the particles/analytes and thereby separate and concentrate it from other particles/analytes.},
doi = {},
url = {https://www.osti.gov/biblio/1165448}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {12}
}

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