Engineering of thermotolerant Bacillus coagulans for production of D(-)-lactic acid

Wang, Qingzhao; Shanmugam, Keelnatham T; Ingram, Lonnie O

Engineering of thermotolerant Bacillus coagulans for production of D(-)-lactic acid

Patent · 02 December 2014

OSTI ID:1164688

Wang, Qingzhao; Shanmugam, Keelnatham T; Ingram, Lonnie O

Genetically modified microorganisms having the ability to produce D(-)-lactic acid at temperatures between 30.degree. C. and 55.degree. C. are provided. In various embodiments, the microorganisms may have the chromosomal lactate dehydrogenase (ldh) gene and/or the chromosomal acetolactate synthase (alsS) gene inactivated. Exemplary microorganisms for use in the disclosed methods are Bacillus spp., such as Bacillus coagulans.

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Research Organization:: University of Florida Research Foundation, Inc., Gainesville, FL (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG36-04GO14019;

Assignee:: University of Florida Research Foundation, Inc. (Gainesville, FL)

Patent Number(s):: 8,900,835

Application Number:: 13/301,836

OSTI ID:: 1164688

Country of Publication:: United States

Language:: English

References (21)

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Engineering of thermotolerant Bacillus coagulans for production of D(-)-lactic acid

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