Mechanism of Amorphous Itraconazole Stabilization in Polymer Solid Dispersions: Role of Molecular Mobility

Bhardwaj, Sunny P.; Arora, Kapildev K.; Kwong, Elizabeth; Templeton, Allen; Clas, Sophie-Dorothee; Suryanarayanan, Raj

doi:10.1021/mp5004515

Title: Mechanism of Amorphous Itraconazole Stabilization in Polymer Solid Dispersions: Role of Molecular Mobility

Full Record
Other Related Research

Authors:

Bhardwaj, Sunny P.; Arora, Kapildev K.; Kwong, Elizabeth; Templeton, Allen; Clas, Sophie-Dorothee; Suryanarayanan, Raj ^[1]

Merck

Publication Date:: Mon Nov 03 00:00:00 EST 2014

Research Org.:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Org.:: USDOE Office of Science (SC)

OSTI Identifier:: 1163783

Resource Type:: Journal Article

Journal Name:: Mol. Pharmacol.

Additional Journal Information:: Journal Volume: 11; Journal Issue: (11) ; 11, 2014

Country of Publication:: United States

Language:: ENGLISH

Citation Formats


                    Bhardwaj, Sunny P., Arora, Kapildev K., Kwong, Elizabeth, Templeton, Allen, Clas, Sophie-Dorothee, Suryanarayanan, Raj, and UMM). Mechanism of Amorphous Itraconazole Stabilization in Polymer Solid Dispersions: Role of Molecular Mobility.  United States: N. p., 2014. 
        Web.  doi:10.1021/mp5004515.

Copy to clipboard


                    Bhardwaj, Sunny P., Arora, Kapildev K., Kwong, Elizabeth, Templeton, Allen, Clas, Sophie-Dorothee, Suryanarayanan, Raj, & UMM). Mechanism of Amorphous Itraconazole Stabilization in Polymer Solid Dispersions: Role of Molecular Mobility.  United States.  https://doi.org/10.1021/mp5004515

Copy to clipboard


                    Bhardwaj, Sunny P., Arora, Kapildev K., Kwong, Elizabeth, Templeton, Allen, Clas, Sophie-Dorothee, Suryanarayanan, Raj, and UMM). 2014.  
        "Mechanism of Amorphous Itraconazole Stabilization in Polymer Solid Dispersions: Role of Molecular Mobility".  United States.  https://doi.org/10.1021/mp5004515.

Copy to clipboard


                    
@article{osti_1163783,

  title        = {Mechanism of Amorphous Itraconazole Stabilization in Polymer Solid Dispersions: Role of Molecular Mobility},

  author       = {Bhardwaj, Sunny P. and Arora, Kapildev K. and Kwong, Elizabeth and Templeton, Allen and Clas, Sophie-Dorothee and Suryanarayanan, Raj and UMM)},

  abstractNote = {},

  doi          = {10.1021/mp5004515},

  url          = {https://www.osti.gov/biblio/1163783},
  journal      = {Mol. Pharmacol.},
number       = (11) ; 11, 2014,

  volume       = 11,

  place        = {United States},

  year         = {Mon Nov 03 00:00:00 EST 2014},

  month        = {Mon Nov 03 00:00:00 EST 2014}

}

Copy to clipboard

Journal Article:

https://doi.org/10.1021/mp5004515

Other availability

Find in Google Scholar

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

The Role of Polymer Concentration on the Molecular Mobility and Physical Stability of Nifedipine Solid Dispersions

Journal Article Kothari, Khushboo; Ragoonanan, Vishard; Suryanarayanan, Raj - Mol. Pharmaceutics
https://doi.org/10.1021/mp500800c
Effect of Polymer Molecular Weight on the Crystallization Behavior of Indomethacin Amorphous Solid Dispersions

Journal Article Mohapatra, Sarat; Samanta, Subarna; Kothari, Khushboo; ... - Crystal Growth and Design

The influence of the molecular weight of polyvinylpyrrolidone (PVP) on the molecular mobility and physical stability of indomethacin (IMC)–PVP solid dispersions was investigated over a wide temperature range in the supercooled state. As the polymer molecular weight increased, there was a decrease in molecular mobility as evident from the longer α-relaxation times. Inhibition of IMC crystallization also increased as a function of polymer molecular weight. The extent of H-bonding interaction between drug and polymer, quantified by ssNMR, was independent of polymer molecular weight. Over a polymer concentration range of 5–20% w/w, the temperature dependence of mobility and viscosity was reasonablymore »« less
Cited by 42
https://doi.org/10.1021/acs.cgd.7b00096

Full Text Available
Influence of Molecular Mobility on the Physical Stability of Amorphous Pharmaceuticals in the Supercooled and Glassy States

Journal Article Kothari, Khushboo; Ragoonanan, Vishard; Suryanarayanan, Raj - Mol. Pharmacol.
https://doi.org/10.1021/mp500229d
Effect of Water on Molecular Mobility and Physical Stability of Amorphous Pharmaceuticals

Journal Article Mehta, Mehak; Kothari, Khushboo; Ragoonanan, Vishard; ... - Molecular Pharmaceutics

In this work, we investigated the influence of sorbed water concentration on the molecular mobility and crystallization behavior in a model amorphous drug and a solid dispersion. The temperature scaling ($$T_g/T$$) allowed us to simultaneously evaluate the effects of water content and temperature on the relaxation time. In the supercooled dispersions, once scaled, the relaxation times of the systems with different water content overlapped. Thus, the observed increase in mobility could be explained by the “plasticization” effect of water. This effect also explained the decrease in crystallization onset temperature brought about by water. That is, plasticization is the underlying mechanismmore »« less
Cited by 66
https://doi.org/10.1021/acs.molpharmaceut.5b00950

Full Text Available
Direct Visualization of Drug–Polymer Phase Separation in Ritonavir–Copovidone Amorphous Solid Dispersions Using in situ Synchrotron X-ray Fluorescence Imaging of Thin Films

Journal Article Shi, Chenyang; Li, Luxi; Zhang, Geoff; ... - Molecular Pharmaceutics

Amorphous solid dispersions (ASDs) are new formulations currently being used in pharmaceutical industry. The ASDs, in which amorphous drug and polymeric excipients are intimately mixed at a molecular level, exhibit dramatically enhanced solubility and dissolution characteristics relative to their crystalline drug counterparts. In the process of achieving an ever-increasing drug loading (DL), it is noticed however, that the drug release profile deteriorates significantly beyond a certain DL. As an example, a ritonavir-copovidone ASD achieves continuous and full drug release when DL ≤ 25 wt%. The release drops at 30 wt% and when DL > 30 wt% there is virtually nomore »« less
Cited by 4
https://doi.org/10.1021/acs.molpharmaceut.9b00651

Full Text Available

Similar Records