3D and 4D magnetic susceptibility tomography based on complex MR images

Chen, Zikuan; Calhoun, Vince D.

Title: 3D and 4D magnetic susceptibility tomography based on complex MR images

Patent · Tue Nov 11 00:00:00 EST 2014

OSTI ID:1163670

Chen, Zikuan; Calhoun, Vince D.

Magnetic susceptibility is the physical property for T2*-weighted magnetic resonance imaging (T2*MRI). The invention relates to methods for reconstructing an internal distribution (3D map) of magnetic susceptibility values, .chi. (x,y,z), of an object, from 3D T2*MRI phase images, by using Computed Inverse Magnetic Resonance Imaging (CIMRI) tomography. The CIMRI technique solves the inverse problem of the 3D convolution by executing a 3D Total Variation (TV) regularized iterative convolution scheme, using a split Bregman iteration algorithm. The reconstruction of .chi. (x,y,z) can be designed for low-pass, band-pass, and high-pass features by using a convolution kernel that is modified from the standard dipole kernel. Multiple reconstructions can be implemented in parallel, and averaging the reconstructions can suppress noise. 4D dynamic magnetic susceptibility tomography can be implemented by reconstructing a 3D susceptibility volume from a 3D phase volume by performing 3D CIMRI magnetic susceptibility tomography at each snapshot time.

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Research Organization:: STC.UNM, Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-08ER64581

Assignee:: STC.UNM (Albuquerque, NM)

Patent Number(s):: 8,886,283

Application Number:: 13/526,210

OSTI ID:: 1163670

Resource Relation:: Patent File Date: 2012 Jun 18

Country of Publication:: United States

Language:: English

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