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Title: Amphiphiles for protein solubilization and stabilization

Abstract

The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.

Inventors:
; ; ;
Publication Date:
Research Org.:
Wisconsin Aumni Research Foundation, Madison, WI (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1163212
Patent Number(s):
8,877,906
Application Number:
13/608,385
Assignee:
Wisconsin Aumni Research Foundation (Madison, WI) ANL
DOE Contract Number:  
W-31-109-ENG38
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Sep 10
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Phillip D, and Wander, Marc J. Amphiphiles for protein solubilization and stabilization. United States: N. p., 2014. Web.
Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Phillip D, & Wander, Marc J. Amphiphiles for protein solubilization and stabilization. United States.
Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Phillip D, and Wander, Marc J. Tue . "Amphiphiles for protein solubilization and stabilization". United States. doi:. https://www.osti.gov/servlets/purl/1163212.
@article{osti_1163212,
title = {Amphiphiles for protein solubilization and stabilization},
author = {Gellman, Samuel Helmer and Chae, Pil Seok and Laible, Phillip D and Wander, Marc J},
abstractNote = {The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 04 00:00:00 EST 2014},
month = {Tue Nov 04 00:00:00 EST 2014}
}

Patent:

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Works referenced in this record:

Synthesis of some aglycon analogs of globotriosylceramide
journal, December 1999


Synthesis and mesogenic properties of a Y-shaped glyco-glycero-lipid
journal, August 2004


Glycotripod Amphiphiles for Solubilization and Stabilization of a Membrane‐Protein Superassembly: Importance of Branching in the Hydrophilic Portion
journal, July 2008

  • Chae, Pil S.; Wander, Marc J.; Bowling, Aaron P.
  • ChemBioChem, Vol. 9, Issue 11, p. 1706-1709
  • DOI: 10.1002/cbic.200800169