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Title: Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease

Abstract

Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with .sup.18F, .sup.123I, or .sup.124I, or free hexoses radiolabeled with .sup.18F, .sup.123I, or .sup.124. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.

Inventors:
; ; ;
Publication Date:
Research Org.:
University of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1160128
Patent Number(s):
8,845,999
Application Number:
11/920,904
Assignee:
The Regents of the University of California (Oakland, CA) OAK
DOE Contract Number:  
FC03-02ER63420
Resource Type:
Patent
Resource Relation:
Patent File Date: 2006 May 23
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Wright, Ernest M, Barrio, Jorge R, Hirayama, Bruce A, and Kepe, Vladimir. Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease. United States: N. p., 2014. Web.
Wright, Ernest M, Barrio, Jorge R, Hirayama, Bruce A, & Kepe, Vladimir. Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease. United States.
Wright, Ernest M, Barrio, Jorge R, Hirayama, Bruce A, and Kepe, Vladimir. Tue . "Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease". United States. doi:. https://www.osti.gov/servlets/purl/1160128.
@article{osti_1160128,
title = {Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease},
author = {Wright, Ernest M and Barrio, Jorge R and Hirayama, Bruce A and Kepe, Vladimir},
abstractNote = {Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with .sup.18F, .sup.123I, or .sup.124I, or free hexoses radiolabeled with .sup.18F, .sup.123I, or .sup.124. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 30 00:00:00 EDT 2014},
month = {Tue Sep 30 00:00:00 EDT 2014}
}

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Works referenced in this record:

Fluorinated carbohydrates : Part XII. 4-deoxy-4-fluoro-D-glucose: an improved synthesis and the glycosyl fluoride derivatives
journal, August 1971


An alternative synthesis of 4-deoxy-4-fluoro-d-glucose and its transport in the human erythrocyte
journal, August 1979