Mobility-Resolved Ion Selection in Uniform Drift Field Ion Mobility Spectrometry/Mass Spectrometry: Dynamic Switching in Structures for Lossless Ion Manipulations

Journal Article · Fri Sep 26 00:00:00 EDT 2014 · Analytical Chemistry

DOI:https://doi.org/10.1021/ac502139e· OSTI ID:1159261

Webb, Ian K. ^[1]; Garimella, Sandilya V. B. ^[1]; Tolmachev, Aleksey V. ^[1]; Chen, Tsung-Chi ^[1]; Zhang, Xinyu ^[1]; Cox, Jonathan T. ^[1]; Norheim, Randolph V. ^[1]; Prost, Spencer A. ^[1]; LaMarche, Brian ^[1]; Anderson, Gordon A. ^[1]; Ibrahim, Yehia M. ^[1]; Smith, Richard D. ^[1]

---

1. Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, 3335 Innovation Avenue (K8-98), P.O. Box 999, Richland, Washington 99352, United States

A Structures for Lossless Ion Manipulations (SLIM) module that allows ion mobility separations and the switching of ions between alternative drift paths is described. The SLIM switch component has a “Tee” configuration and allows switching of ions between a linear path and a 90-degree bend. By controlling switching times, ions can be deflected to an alternative channel as a function of their mobilities. In the initial evaluation the switch is used in a static mode and shown compatible with high performance ion mobility separations at 4 torr. In the “dynamic mode” we show that mobility-selected ions can be switched into the alternative channel, and that various ion species can be independently selected based on their mobilities for time-of-flight mass spectrometer (TOF MS) IMS detection and mass analysis. Ultimately, this development also provides the basis for e.g. the selection of specific mobilities for storage and accumulation, and key modules for the assembly of SLIM devices enabling much more complex sequences of ion manipulations.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)
• Sponsoring Organization: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Institutes of Health (NIH)
• Grant/Contract Number: AC05-76RL01830; GM103493
• OSTI ID: 1159261
• Alternate ID(s): OSTI ID: 1167645
• Report Number(s): PNNL-SA-103347
• Journal Information: Analytical Chemistry, Journal Name: Analytical Chemistry Vol. 86 Journal Issue: 19; ISSN 0003-2700
• Publisher: American Chemical Society
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Environmental Molecular Sciences Laboratory
A Structures for Lossless Ion Manipulations
SLIM
alternative drift paths
ion manipulation