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Title: Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

Authors:
 [1];  [1];  [2];  [2];  [3];  [4];  [4];  [1];  [4];  [2];  [5]
  1. Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States
  2. Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee 37208, United States
  3. Synchrotron Research Center, Life Science Collaborative Access Team, Northwestern University, Argonne, Illinois 60439, United States
  4. “Istituto Pasteur-Fondazione Cenci Bolognetti”, Department of “Chimica e Tecnologie del Farmaco”, Sapienza University of Rome, Rome, 00185, Italy
  5. Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, United States
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1158716
Resource Type:
Journal Article: Published Article
Journal Name:
Journal of Medicinal Chemistry
Additional Journal Information:
Journal Volume: 57; Journal Issue: 15; Related Information: CHORUS Timestamp: 2017-11-09 11:32:39; Journal ID: ISSN 0022-2623
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English

Citation Formats

Friggeri, Laura, Hargrove, Tatiana Y., Rachakonda, Girish, Williams, Amanda D., Wawrzak, Zdzislaw, Di Santo, Roberto, De Vita, Daniela, Waterman, Michael R., Tortorella, Silvano, Villalta, Fernando, and Lepesheva, Galina I. Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition. United States: N. p., 2014. Web. doi:10.1021/jm500739f.
Friggeri, Laura, Hargrove, Tatiana Y., Rachakonda, Girish, Williams, Amanda D., Wawrzak, Zdzislaw, Di Santo, Roberto, De Vita, Daniela, Waterman, Michael R., Tortorella, Silvano, Villalta, Fernando, & Lepesheva, Galina I. Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition. United States. doi:10.1021/jm500739f.
Friggeri, Laura, Hargrove, Tatiana Y., Rachakonda, Girish, Williams, Amanda D., Wawrzak, Zdzislaw, Di Santo, Roberto, De Vita, Daniela, Waterman, Michael R., Tortorella, Silvano, Villalta, Fernando, and Lepesheva, Galina I. Tue . "Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition". United States. doi:10.1021/jm500739f.
@article{osti_1158716,
title = {Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition},
author = {Friggeri, Laura and Hargrove, Tatiana Y. and Rachakonda, Girish and Williams, Amanda D. and Wawrzak, Zdzislaw and Di Santo, Roberto and De Vita, Daniela and Waterman, Michael R. and Tortorella, Silvano and Villalta, Fernando and Lepesheva, Galina I.},
abstractNote = {},
doi = {10.1021/jm500739f},
journal = {Journal of Medicinal Chemistry},
number = 15,
volume = 57,
place = {United States},
year = {Tue Jul 29 00:00:00 EDT 2014},
month = {Tue Jul 29 00:00:00 EDT 2014}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1021/jm500739f

Citation Metrics:
Cited by: 14works
Citation information provided by
Web of Science

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