skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Methods and systems for Raman and optical cross-interrogation in flow-through silicon membranes

Patent ·
OSTI ID:1156954

Cross-interrogating photonic detection systems and methods are shown. A flow through photonic crystal membrane with a surface enhanced Raman scattering (SERS) substrate is provided with pores which are distributed along multiple regions. The pores of one region have walls to which a first type of target specific anchor can be attached, while pores of another region have walls to which a second type of target specific anchor can be attached. An optical arrangement out-of-plane to the SERS substrate is also provided for enhanced sensitivity and identification of target organisms.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC52-07NA27344
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Number(s):
8,830,450
Application Number:
12/958,302
OSTI ID:
1156954
Country of Publication:
United States
Language:
English

References (149)

Apparatus and method for providing assay calibration data patent May 1994
Raman optrode processes and devices for detection of chemicals and microorganisms patent February 1999
Fabrication of optical devices based on two dimensional photonic crystal structures and apparatus made thereby patent October 2002
Photonic crystal waveguide patent November 2003
Method and a system for determination of particles in a liquid sample patent March 2004
Two-dimensional photonic crystal, and multiplexer/demultiplexer using the same patent May 2004
Target molecules detection by waveguiding in a photonic silicon membrane patent August 2004
Support for chromophoric elements patent March 2005
Method and systems for dynamically controlling electromagnetic wave motion through a photonic crystal patent April 2006
Optical phase measurement of target patent April 2006
Target molecules detection by waveguiding in a photonic silicon membrane patent December 2006
Coupled photonic crystal resonator array arrangements and applications patent April 2007
Mach Zehnder photonic crystal sensors and methods patent October 2007
Surface plasmon enhanced illumination system patent January 2008
Optical sensor with layered plasmon structure for enhanced detection of chemical groups by SERS patent April 2008
Nanoscale structures, systems, and methods for use in nano-enhanced raman spectroscopy (NERS) patent June 2008
Addressable field enhancement microscopy patent January 2009
Photonic crystal laser sensors and methods patent February 2009
Random texture anti-reflection optical surface treatment patent May 2012
Rapid and sensitive detection of molecules patent-application July 2003
Method and systems for dynamically controlling electromagnetic wave motion through a photonic crystal patent-application February 2004
Chemical sensor based on the optical superprism effect in photonic crystals patent-application April 2004
Method and device for detecting a small number of molecules using surface-enhanced coherant anti-stokes raman spectroscopy patent-application April 2005
Optical measuring method and laboratory measuring device patent-application September 2005
Photonic crystal laser sensors and methods patent-application April 2006
Multiplexed Photonic Membranes and Related Detection Methods for Chemical and/or Biological Sensing Applications patent-application October 2009
Nanoscale Array Structures Suitable for Surface Enhanced Raman Scattering and Methods Related Thereto patent-application June 2011
Self-referenced assay method for photonic crystal biosensors: Application to small molecule analytes journal January 2007
Ultracompact biochemical sensor built with two-dimensional photonic crystal microcavity journal January 2004
New method for attachment of biomolecules to porous siliconElectronic supplementary information available. Experimental section. See http://www.rsc.org/suppdata/cc/b2/b209453c/ journal January 2003
Nanoscale microcavity sensor for single particle detection journal January 2007
Enzyme Immobilization on Porous Silicon Surfaces journal February 2004
Functionalized silicon membranes for selective bio-organism capture journal April 2003
Zero-Mode Waveguides for Single-Molecule Analysis at High Concentrations journal January 2003
A Porous Silicon-Based Optical Interferometric Biosensor journal October 1997
Photonic crystal laser sources for chemical detection journal June 2003
Immobilization of antibodies in micropatterns for cell detection by optical diffraction journal November 2000
Identification of Gram Negative Bacteria Using Nanoscale Silicon Microcavities journal November 2001
Nanocavity in a silicon waveguide for ultrasensitive nanoparticle detection journal November 2004
Localized Functionalization of Single Nanopores journal February 2006
Sensing Characteristics of NIR Localized Surface Plasmon Resonances in Gold Nanorings for Application as Ultrasensitive Biosensors journal May 2007
Integration of porous silicon chips in an electronic artificial nose journal September 2000
Detection of bio-organism simulants using random binding on a defect-free photonic crystal journal September 2010
In situ determination of refractive index and size of Bacillus spores by light transmission journal January 2005
New biochip technology for label-free detection of pathogens and their toxins journal May 2003
Membrane-Based Electrochemical Nanobiosensor for the Detection of Virus journal September 2009
Silicon photonic crystal nanostructures for refractive index sensing journal November 2008
Single virus detection from the reactive shift of a whispering-gallery mode journal December 2008
Effects of fluctuation in air hole radii and positions on optical characteristics in photonic crystal heterostructure nanocavities journal February 2009
Fabrication and characterization of a porous silicon based microarray for label-free optical monitoring of biomolecular interactions journal January 2010
Bacillus Spore Classification via Surface-Enhanced Raman Spectroscopy and Principal Component Analysis journal March 2008
Real-time detection of airborne viruses on a mass-sensitive device journal July 2008
Technology Challenges in Responding to Biological or Chemical Attacks in the Civilian Sector journal November 2003
National validation study of a swab protocol for the recovery of Bacillus anthracis spores from surfaces journal May 2010
Cryo-electron tomography of vaccinia virus journal February 2005
The Smart Petri Dish:  A Nanostructured Photonic Crystal for Real-Time Monitoring of Living Cells journal August 2006
Determination of the Efficacy of Two Building Decontamination Strategies by Surface Sampling with Culture and Quantitative PCR Analysis journal August 2004
Liquid-infiltrated photonic crystals: enhanced light-matter interactions for lab-on-a-chip applications journal August 2007
Towards on-site pathogen detection using antibody-based sensors journal November 2008
Surface-Enhanced Raman Spectroscopy and Homeland Security: A Perfect Match? journal September 2009
InP-based two-dimensional photonic crystals filled with polymers journal April 2006
Specific detection of proteins using photonic crystal waveguides journal January 2008
Improved Localized Surface Plasmon Resonance Immunoassay with Gold Bipyramid Substrates journal June 2009
Most-Probable-Number Rapid Viability PCR method to detect viable spores of Bacillus anthracis in swab samples journal May 2010
Rapid, high-throughput, culture-based PCR methods to analyze samples for viable spores of Bacillus anthracis and its surrogates journal March 2009
Design of nanoslotted photonic crystal waveguide cavities for single nanoparticle trapping and detection journal January 2009
Characterization of a commercialized SERS-active substrate and its application to the identification of intact Bacillus endospores journal January 2007
Analysis of the experimental Q factors (~ 1 million) of photonic crystal nanocavities journal January 2006
Multilayer silver nanoparticles-modified optical fiber tip for high performance SERS remote sensing journal June 2010
Plasmon Resonance Shifts of Au-Coated Au 2 S Nanoshells: Insight into Multicomponent Nanoparticle Growth journal June 1997
Nanopillars array for surface enhanced Raman scattering conference May 2011
Localized Surface Plasmon Resonance Sensing of Lipid-Membrane-Mediated Biorecognition Events journal April 2005
Fabrication of nanodot plasmonic waveguide structures using FIB milling and electron beam-induced deposition journal July 2009
Gold–Silica–Gold Nanosandwiches: Tunable Bimodal Plasmonic Resonators journal February 2007
The discrete-dipole approximation and its application to interstellar graphite grains journal October 1988
Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles journal August 1997
Surface Plasmon Resonance Scattering and Absorption of anti-EGFR Antibody Conjugated Gold Nanoparticles in Cancer Diagnostics: Applications in Oral Cancer journal May 2005
Fiber coupled waveguide grating structures journal March 2010
Raman spectra of pyridine adsorbed at a silver electrode journal May 1974
Remote surface enhanced Raman spectroscopy imaging via a nanostructured optical fiber bundle journal January 2009
Confined Plasmons in Nanofabricated Single Silver Particle Pairs:  Experimental Observations of Strong Interparticle Interactions journal January 2005
Silver Nanostructures on Silicon Based on Galvanic Displacement Process journal September 2009
A Nanoscale Optical Biosensor:  Sensitivity and Selectivity of an Approach Based on the Localized Surface Plasmon Resonance Spectroscopy of Triangular Silver Nanoparticles journal September 2002
A Localized Surface Plasmon Resonance Biosensor: First Steps toward an Assay for Alzheimer's Disease journal June 2004
Optical Properties of Short Range Ordered Arrays of Nanometer Gold Disks Prepared by Colloidal Lithography journal June 2003
Nanostructured model biomaterial surfaces prepared by colloidal lithography journal January 1999
Exploitation of Localized Surface Plasmon Resonance journal October 2004
Nanosphere Lithography:  Effect of the External Dielectric Medium on the Surface Plasmon Resonance Spectrum of a Periodic Array of Silver Nanoparticles journal November 1999
Nanosphere Lithography:  Surface Plasmon Resonance Spectrum of a Periodic Array of Silver Nanoparticles by Ultraviolet−Visible Extinction Spectroscopy and Electrodynamic Modeling journal April 1999
Quantitative Interpretation of the Response of Surface Plasmon Resonance Sensors to Adsorbed Films journal September 1998
Patterned Arrays of Au Rings for Localized Surface Plasmon Resonance journal August 2006
Study of Molecular Trapping Inside Gold Nanofinger Arrays on Surface-Enhanced Raman Substrates journal June 2011
Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS) journal March 1997
Surface-enhanced Raman scattering and biophysics journal April 2002
Nanoimprinted optical fibres: Biotemplated nanostructures for SERS sensing journal January 2009
Plasmonic Properties of Supported Pt and Pd Nanostructures journal April 2006
Fiber-optic SERS sensor with optimized geometry journal February 2007
Chain Length Dependence and Sensing Capabilities of the Localized Surface Plasmon Resonance of Silver Nanoparticles Chemically Modified with Alkanethiol Self-Assembled Monolayers
  • Malinsky, Michelle Duval; Kelly, K. Lance; Schatz, George C.
  • Journal of the American Chemical Society, Vol. 123, Issue 7, p. 1471-1482 https://doi.org/10.1021/ja003312a
journal February 2001
Single Silver Nanoparticles as Real-Time Optical Sensors with Zeptomole Sensitivity journal August 2003
Sensitivity of Metal Nanoparticle Surface Plasmon Resonance to the Dielectric Environment journal November 2005
Local Refractive Index Dependence of Plasmon Resonance Spectra from Individual Nanoparticles journal April 2003
Sensing Capabilities of Colloidal Gold Modified with a Self-Assembled Monolayer of a Glucose-Carrying Polymer Chain on a Glass Substrate journal September 2004
A Colorimetric Gold Nanoparticle Sensor To Interrogate Biomolecular Interactions in Real Time on a Surface journal February 2002
Optical Properties of Star-Shaped Gold Nanoparticles journal April 2006
Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering journal February 1997
Local plasmon sensor with gold colloid monolayers deposited upon glass substrates journal January 2000
Surface-Based Gold-Nanoparticle Sensor for Specific and Quantitative DNA Hybridization Detection journal November 2003
Plasmonics: Merging Photonics and Electronics at Nanoscale Dimensions journal January 2006
Optical Spectroscopy of Nanometric Holes in Thin Gold Films journal June 2004
Scattering and Absorption of Light by Nonspherical Dielectric Grains journal December 1973
Biomolecular Recognition Based on Single Gold Nanoparticle Light Scattering journal May 2003
Calibration of Dynamic Molecular Rulers Based on Plasmon Coupling between Gold Nanoparticles journal November 2005
Plasmonic Sensing Characteristics of Single Nanometric Holes journal November 2005
Internal Electric Field Densities of Metal Nanoshells journal February 2005
Rapid and Sensitive Detection of Respiratory Virus Molecular Signatures Using a Silver Nanorod Array SERS Substrate journal November 2006
Localized Surface Plasmon Resonance Spectroscopy of Single Silver Triangular Nanoprisms journal September 2006
Optical characterization of electronic transitions arising from the Au/S interface of self-assembled n-alkanethiolate monolayers journal November 1995
Fabrication of Crescent-Shaped Optical Antennas journal September 2005
Spectroscopy of single metallic nanoparticles using total internal reflection microscopy journal November 2000
Increased Sensitivity of Surface Plasmon Resonance of Gold Nanoshells Compared to That of Gold Solid Colloids in Response to Environmental Changes journal October 2002
Patterns of DNA-Labeled and scFv-Antibody-Carrying Lipid Vesicles Directed by Material-Specific Immobilization of DNA and Supported Lipid Bilayer Formation on an Au/SiO2 Template journal March 2003
Optical Antenna Arrays on a Fiber Facet for in Situ Surface-Enhanced Raman Scattering Detection journal March 2009
Geometrical Parameters Controlling Sensitivity of Nanoshell Plasmon Resonances to Changes in Dielectric Environment journal November 2004
Langmuir−Blodgett Silver Nanowire Monolayers for Molecular Sensing Using Surface-Enhanced Raman Spectroscopy journal September 2003
Single-fibre surface-enhanced Raman sensors with angled tips journal January 2000
Comparison of fibre-optic SERS sensors with differently prepared tips journal August 1998
Nanorice:  A Hybrid Plasmonic Nanostructure journal April 2006
Highly Sensitive Detection of Proteins and Bacteria in Aqueous Solution Using Surface-Enhanced Raman Scattering and Optical Fibers journal August 2011
High-sensitivity molecular sensing using hollow-core photonic crystal fiber and surface-enhanced Raman scattering journal January 2010
Portable fiber sensors based on surface-enhanced Raman scattering journal December 2010
Nanopillar array on a fiber facet for highly sensitive surface-enhanced Raman scattering journal January 2012
A Comparative Analysis of Localized and Propagating Surface Plasmon Resonance Sensors:  The Binding of Concanavalin A to a Monosaccharide Functionalized Self-Assembled Monolayer journal October 2004
Development of silver nanorod array based fiber optic probes for SERS detection journal September 2011
Plasmon Resonant Cavities in Vertical Nanowire Arrays journal August 2010
Rigorous surface enhanced Raman spectral characterization of large-area high-uniformity silver-coated tapered silica nanopillar arrays journal September 2010
Rapidly reconfigurable all-optical universal logic gates conference October 2006
Discrimination of Bacteria Using Surface-Enhanced Raman Spectroscopy journal January 2004
Sampled-grating DBR laser-based analog optical transmitters journal December 2003
Silver-Molecule Separation Dependence of Surface-Enhanced Raman Scattering journal January 1981
All-optical set-reset operation in a distributed feedback GaInAsP waveguide journal January 1998
Optical injection induced polarization bistability in vertical‐cavity surface‐emitting lasers journal November 1993
Gain lever characterization in monolithically integrated diode lasers conference April 2005
Realization of All-Optical Flip-Flop Using Directionally Coupled Bistable Laser Diode journal January 2004
Multimode interference bistable laser diode journal August 2003
Operation Characteristics of a Side-Light-Injection Multiple-Quantum-Well Bistable Laser for All-Optical Switching journal January 1994
Cancer gene detection using surface-enhanced Raman scattering (SERS) journal January 2002
All-optical bistable switching dynamics in 1.55-μm two-segment strained multiquantum-well distributed-feedback lasers journal January 1997
Use of interference lithography to pattern arrays of submicron resist structures for field emission flat panel displays journal May 1997
Integrated laser with low-loss high-index-contrast waveguides for OEICs conference March 2005

Cited By (1)


Similar Records

Related Subjects