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Title: Combined hairpin-antisense compositions and methods for modulating expression

Abstract

A nucleotide construct comprising a nucleotide sequence that forms a stem and a loop, wherein the loop comprises a nucleotide sequence that modulates expression of a target, wherein the stem comprises a nucleotide sequence that modulates expression of a target, and wherein the target modulated by the nucleotide sequence in the loop and the target modulated by the nucleotide sequence in the stem may be the same or different. Vectors, methods of regulating target expression, methods of providing a cell, and methods of treating conditions comprising the nucleotide sequence are also disclosed.

Inventors:
;
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1150002
Patent Number(s):
8,796,442
Application Number:
12/052,658
Assignee:
Brookhaven Science Associates, LLC (Upton, NY) BNL
DOE Contract Number:
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Shanklin, John, and Nguyen, Tam. Combined hairpin-antisense compositions and methods for modulating expression. United States: N. p., 2014. Web.
Shanklin, John, & Nguyen, Tam. Combined hairpin-antisense compositions and methods for modulating expression. United States.
Shanklin, John, and Nguyen, Tam. Tue . "Combined hairpin-antisense compositions and methods for modulating expression". United States. doi:. https://www.osti.gov/servlets/purl/1150002.
@article{osti_1150002,
title = {Combined hairpin-antisense compositions and methods for modulating expression},
author = {Shanklin, John and Nguyen, Tam},
abstractNote = {A nucleotide construct comprising a nucleotide sequence that forms a stem and a loop, wherein the loop comprises a nucleotide sequence that modulates expression of a target, wherein the stem comprises a nucleotide sequence that modulates expression of a target, and wherein the target modulated by the nucleotide sequence in the loop and the target modulated by the nucleotide sequence in the stem may be the same or different. Vectors, methods of regulating target expression, methods of providing a cell, and methods of treating conditions comprising the nucleotide sequence are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 05 00:00:00 EDT 2014},
month = {Tue Aug 05 00:00:00 EDT 2014}
}

Patent:

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