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Title: Extracellular secretion of recombinant proteins

Abstract

Nucleic acids encoding secretion signals, expression vectors containing the nucleic acids, and host cells containing the expression vectors are disclosed. Also disclosed are polypeptides that contain the secretion signals and methods of producing polypeptides, including methods of directing the extracellular secretion of the polypeptides. Exemplary embodiments include cellulase proteins fused to secretion signals, methods to produce and isolate these polypeptides, and methods to degrade lignocellulosic biomass.

Inventors:
;
Publication Date:
Research Org.:
National Energy Technology Lab. (NETL), Pittsburgh, PA, and Morgantown, WV (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1149687
Patent Number(s):
8,785,159
Application Number:
12/950,442
Assignee:
Alliance for Sustainable Energy, LLC (Golden, CO) NREL
DOE Contract Number:  
AC36-08G028308
Resource Type:
Patent
Resource Relation:
Patent File Date: 2010 Nov 19
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Linger, Jeffrey G., and Darzins, Aldis. Extracellular secretion of recombinant proteins. United States: N. p., 2014. Web.
Linger, Jeffrey G., & Darzins, Aldis. Extracellular secretion of recombinant proteins. United States.
Linger, Jeffrey G., and Darzins, Aldis. Tue . "Extracellular secretion of recombinant proteins". United States. doi:. https://www.osti.gov/servlets/purl/1149687.
@article{osti_1149687,
title = {Extracellular secretion of recombinant proteins},
author = {Linger, Jeffrey G. and Darzins, Aldis},
abstractNote = {Nucleic acids encoding secretion signals, expression vectors containing the nucleic acids, and host cells containing the expression vectors are disclosed. Also disclosed are polypeptides that contain the secretion signals and methods of producing polypeptides, including methods of directing the extracellular secretion of the polypeptides. Exemplary embodiments include cellulase proteins fused to secretion signals, methods to produce and isolate these polypeptides, and methods to degrade lignocellulosic biomass.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jul 22 00:00:00 EDT 2014},
month = {Tue Jul 22 00:00:00 EDT 2014}
}

Patent:

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