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Title: Robust, self-assembled, biocompatible films

Abstract

The present invention provides a composite material including a substrate having an oxide surface, and, a continuous monolayer on the oxide surface, the monolayer including a silicon atom from a trifunctional alkyl/alkenyl/alkynyl silane group that attaches to the oxide surface, an alkyl/alkenyl/alkynyl portion of at least three carbon atoms, a polyalkylene glycol spacer group, and either a reactive site (e.g., a recognition ligand) or a site resistant to non-specific binding (e.g., a methoxy or the like) at the terminus of each modified SAM. The present invention further provides a sensor element, a sensor array and a method of sensing, each employing the composite material. Patterning is also provided together with backfilling to minimize non-specific binding.

Inventors:
; ; ;
Publication Date:
Research Org.:
LANL (Los Alamos National Laboratory (LANL), Los Alamos, NM (United States))
Sponsoring Org.:
USDOE
OSTI Identifier:
1136180
Patent Number(s):
8,759,008
Application Number:
12/777,837
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM) LANL
DOE Contract Number:  
AC51-06NA25396
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Swanson, Basil I, Anderson, Aaron S., Dattelbaum, Andrew M., and Schmidt, Jurgen G. Robust, self-assembled, biocompatible films. United States: N. p., 2014. Web.
Swanson, Basil I, Anderson, Aaron S., Dattelbaum, Andrew M., & Schmidt, Jurgen G. Robust, self-assembled, biocompatible films. United States.
Swanson, Basil I, Anderson, Aaron S., Dattelbaum, Andrew M., and Schmidt, Jurgen G. Tue . "Robust, self-assembled, biocompatible films". United States. doi:. https://www.osti.gov/servlets/purl/1136180.
@article{osti_1136180,
title = {Robust, self-assembled, biocompatible films},
author = {Swanson, Basil I and Anderson, Aaron S. and Dattelbaum, Andrew M. and Schmidt, Jurgen G.},
abstractNote = {The present invention provides a composite material including a substrate having an oxide surface, and, a continuous monolayer on the oxide surface, the monolayer including a silicon atom from a trifunctional alkyl/alkenyl/alkynyl silane group that attaches to the oxide surface, an alkyl/alkenyl/alkynyl portion of at least three carbon atoms, a polyalkylene glycol spacer group, and either a reactive site (e.g., a recognition ligand) or a site resistant to non-specific binding (e.g., a methoxy or the like) at the terminus of each modified SAM. The present invention further provides a sensor element, a sensor array and a method of sensing, each employing the composite material. Patterning is also provided together with backfilling to minimize non-specific binding.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 24 00:00:00 EDT 2014},
month = {Tue Jun 24 00:00:00 EDT 2014}
}

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Works referenced in this record:

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