Microfluidic ultrasonic particle separators with engineered node locations and geometries

Rose, Klint A; Fisher, Karl A; Wajda, Douglas A; Mariella, Jr., Raymond P; Bailey, Christoppher; Dehlinger, Dietrich; Shusteff, Maxim; Jung, Byoungsok; Ness, Kevin D

Title: Microfluidic ultrasonic particle separators with engineered node locations and geometries

Patent · Tue May 20 00:00:00 EDT 2014

OSTI ID:1132523

Rose, Klint A; Fisher, Karl A; Wajda, Douglas A; Mariella, Jr., Raymond P; Bailey, Christoppher; Dehlinger, Dietrich; Shusteff, Maxim; Jung, Byoungsok; Ness, Kevin D

An ultrasonic microfluidic system includes a separation channel for conveying a sample fluid containing small particles and large particles, flowing substantially parallel, adjacent to a recovery fluid, with which it is in contact. An acoustic transducer produces an ultrasound standing wave, that generates a pressure field having at least one node of minimum pressure amplitude. An acoustic extension structure is located proximate to said separation channel for positioning said acoustic node off center in said acoustic area and concentrating the large particles in said recovery fluid stream.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-07NA27344

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Number(s):: 8,727,129

Application Number:: 13/571,640

OSTI ID:: 1132523

Resource Relation:: Patent File Date: 2012 Aug 10

Country of Publication:: United States

Language:: English

References (9)

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Component Separation Device Takahashi, Makoto; Nakatani, Masaya; Hiraoka, Soichiro https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100126922 US Patent Application 12/532908; 20100126922	patent-application	May 2010
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Micro-manipulation of small particles by node position control of an ultrasonic standing wave Haake, A.; Dual, J. Ultrasonics, Vol. 40, Issue 1-8, p. 317-322 https://doi.org/10.1016/S0041-624X(02)00114-2	journal	May 2002
Filtration of bacteria and yeast by ultrasound-enhanced sedimentation Hawkes, J. J.; Limaye, M. S.; Coakley, W. T. Journal of Applied Microbiology, Vol. 82, Issue 1 https://doi.org/10.1111/j.1365-2672.1997.tb03295.x	journal	January 1997
Multi-modal particle manipulator to enhance bead-based bioassays Glynne-Jones, P.; Boltryk, R. J.; Hill, M. Ultrasonics, Vol. 50, Issue 2, p. 235-239 https://doi.org/10.1016/j.ultras.2009.09.025	journal	February 2010
Acoustic Particle Filter with Adjustable Effective Pore Size for Automated Sample Preparation Jung, Byoungsok; Fisher, Karl; Ness, Kevin D. Analytical Chemistry, Vol. 80, Issue 22 https://doi.org/10.1021/ac8011768	journal	November 2008
Chip integrated strategies for acoustic separation and manipulation of cells and particles Laurell, Thomas; Petersson, Filip; Nilsson, Andreas Chem. Soc. Rev., Vol. 36, Issue 3 https://doi.org/10.1039/B601326K	journal	January 2007

Cited By (2)

Microfluidic ultrasonic particle separators with engineered node locations and geometries Rose, Klint A.; Fisher, Karl A.; Wajda, Douglas A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9321050 US Patent Document 9,321,050	patent	April 2016
Microfluidic ultrasonic particle separators with engineered node locations and geometries Rose, Klint A.; Fisher, Karl A.; Wajda, Douglas A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8991614 US Patent Document 8,991,614	patent	March 2015

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