Detection of bioagents using a shear horizontal surface acoustic wave biosensor

Larson, Richard S; Hjelle, Brian; Hall, Pam R; Brown, David C; Bisoffi, Marco; Brozik, Susan M; Branch, Darren W; Edwards, Thayne L; Wheeler, David

Title: Detection of bioagents using a shear horizontal surface acoustic wave biosensor

Patent · Tue Apr 29 00:00:00 EDT 2014

OSTI ID:1130065

Larson, Richard S; Hjelle, Brian; Hall, Pam R; Brown, David C; Bisoffi, Marco; Brozik, Susan M; Branch, Darren W; Edwards, Thayne L; Wheeler, David

A biosensor combining the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In a preferred embodiment, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV). Rapid detection of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, and the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1 The biosensor was able to delect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS).

View Patent

Cite

Export

Save

Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: STC.UNM (Albuquerque, NM); Sandia National Laboratories (Albuquerque, NM)

Patent Number(s):: 8,709,791

Application Number:: 12/069,284

OSTI ID:: 1130065

Resource Relation:: Patent File Date: 2008 Feb 08

Country of Publication:: United States

Language:: English

References (32)

Assay method for biological target complexes on the surface of a biosensor Ebersole, Richard C.; Moran, John R.; Ward, Michael https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5658732 US Patent Document 5,658,732	patent	August 1997
Ambipolar organic transistor Geens, Wim; Poortmans, Jef; Aernouts, Tom https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030085397 US Patent Application 10/281385; 20030085397	patent-application	May 2003
Acoustic wave sensor apparatus, method and system using wide bandgap materials Auner, Gregory W.; Zhong, Feng; Hughes, Chantelle https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030196477 US Patent Application 10/125031; 20030196477	patent-application	October 2003
Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators Shipwash, Edward https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040005582 US Patent Application 10/327531; 20040005582	patent-application	January 2004
Surface acoustic wave sensors and method for detecting target analytes Warthoe, Peter; Iben, Soerensen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040072208 US Patent Application 29586992; 20040072208	patent-application	April 2004
Nano-mechanic microsensors and methods for detecting target analytes Warthoe, Peter https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060024813 US Patent Application 11/134821; 20060024813	patent-application	February 2006
Systems and methods for molecular recognition Hunt, William D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060029929 US Patent Application 10/863150; 20060029929	patent-application	February 2006
Differentiation and identification of analogous chemical or biological substances with biosensors Edmonson, Peter J.; Hunt, William D.; Stubbs, Desmond D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060213271 US Patent Application 11/088809; 20060213271	patent-application	September 2006
System with Extended Range of Molecular Sensing Through Integrated Multi-modal Data Acquisition Wang, Xuefeng; Nolte, David D.; Varma, Manoj https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080186477 US Patent Application 12/018108; 20080186477	patent-application	August 2008
Detection of Escherichia coli O157:H7 with langasite pure shear horizontal surface acoustic wave sensors Berkenpas, E.; Millard, P.; Pereira da Cunha, M. Biosensors and Bioelectronics, Vol. 21, Issue 12, p. 2255-2262 https://doi.org/10.1016/j.bios.2005.11.005	journal	June 2006
Low-level detection of a Bacillus anthracis simulant using Love-wave biosensors on 36°YX LiTaO₃ Branch, Darren W.; Brozik, Susan M. Biosensors and Bioelectronics, Vol. 19, Issue 8, p. 849-859 https://doi.org/10.1016/j.bios.2003.08.020	journal	March 2004
Viral Agents as Biological Weapons and Agents of Bioterrorism Bronze, Michael S.; Huycke, Mark M.; Machado, Linda J. The American Journal of the Medical Sciences, Vol. 323, Issue 6, p. 316-325 https://doi.org/10.1097/00000441-200206000-00004	journal	June 2002
Biosensors for the detection of bacteria Deisingh, Anil K.; Thompson, Michael Canadian Journal of Microbiology, Vol. 50, Issue 2, p. 69-77 https://doi.org/10.1139/w03-095	journal	February 2004
Vaccines against hantaviruses Hjelle, Brian Expert Review of Vaccines, Vol. 1, Issue 3, p. 373-384 https://doi.org/10.1586/14760584.1.3.373	journal	October 2002
Seroepidemiologic Studies of Hantavirus Infection Among Wild Rodents in California Jay, Michele Emerging Infectious Diseases, Vol. 3, Issue 2, p. 183-190 https://doi.org/10.3201/eid0302.970213	journal	June 1997
Pulse mode shear horizontal-surface acoustic wave (SH-SAW) system for liquid based sensing applications Martin, Fabrice; Newton, Michael I.; McHale, Glen Biosensors and Bioelectronics, Vol. 19, Issue 6, p. 627-632 https://doi.org/10.1016/S0956-5663(03)00257-4	journal	January 2004
Diagnosis and treatment of new world hantavirus infections Mertz, Gregory J.; Hjelle, Brian; Crowley, Mark Current Opinion in Infectious Diseases, Vol. 19, Issue 5, p. 437-442 https://doi.org/10.1097/01.qco.0000244048.38758.1f	journal	January 2006
A Love wave immunosensor for whole E. coli bacteria detection using an innovative two-step immobilisation approach Moll, Nicolas; Pascal, Emilie; Dinh, Duy Haï Biosensors and Bioelectronics, Vol. 22, Issue 9-10, p. 2145-2150 https://doi.org/10.1016/j.bios.2006.09.032	journal	April 2007
Enteroviruses as agents of emerging infectious diseases Palacios, G.; Oberste, M. S. Journal of Neurovirology, Vol. 11, Issue 5, p. 424-433 https://doi.org/10.1080/13550280591002531	journal	January 2005
Coxsackievirus Myocarditis: Interplay between Virus and Host in the Pathogenesis of Heart Disease Tam, Patricia E. Viral Immunology, Vol. 19, Issue 2, p. 133-146 https://doi.org/10.1089/vim.2006.19.133	journal	June 2006
Real time device for biosensing: design of a bacteriophage model using love acoustic waves Tamarin, O.; Comeau, S.; Déjous, C. Biosensors and Bioelectronics, Vol. 18, Issue 5-6, p. 755-763 https://doi.org/10.1016/S0956-5663(03)00022-8	journal	May 2003
Binding affinity and inhibitory potency of neomycin and streptomycin on the Tat peptide interaction with HIV-1 TAR RNA detected by on-line acoustic wave sensor Tassew, Nardos; Thompson, Michael Organic & Biomolecular Chemistry, Vol. 1, Issue 19, p. 3268-3270 https://doi.org/10.1039/b307620m	journal	January 2003
Selection and characterization of scFv antibodies against the Sin Nombre hantavirus nucleocapsid protein Velappan, Nileena; Martinez, Jennifer S.; Valero, Rosa Journal of Immunological Methods, Vol. 321, Issue 1-2, p. 60-69 https://doi.org/10.1016/j.jim.2007.01.011	journal	April 2007
Sin Nombre Viral RNA Load in Patients with Hantavirus Cardiopulmonary Syndrome Xiao, Ruobing; Yang, Shu; Koster, Fred The Journal of Infectious Diseases, Vol. 194, Issue 10, p. 1403-1409 https://doi.org/10.1086/508494	journal	November 2006
4D-4 Love Wave Acoustic Array Biosensor Platform for Autonomous Detection Branch, D. W.; Edwards, T. L. 2007 IEEE Ultrasonics Symposium Proceedings https://doi.org/10.1109/ULTSYM.2007.76	conference	October 2007
Chemical Vapor Deposition of Conformal, Functional, and Responsive Polymer Films Alf, Mahriah E.; Asatekin, Ayse; Barr, Miles C. Advanced Materials, Vol. 22, Issue 18, p. 1993-2027 https://doi.org/10.1002/adma.200902765	journal	December 2009
Vacuum-deposited wave-guiding layers on STW resonators based on LiTaO₃ substrate as love wave sensors for chemical and biochemical sensing in liquids Barié, Nicole; Stahl, Ullrich; Rapp, Michael Ultrasonics, Vol. 50, Issue 6, p. 606-612 https://doi.org/10.1016/j.ultras.2009.12.006	journal	May 2010
Design and properties of quartz-based Love wave acoustic sensors incorporating silicon dioxide and PMMA guiding layers Harding, Geoffrey L.; Du, Jia Smart Materials and Structures, Vol. 6, Issue 6, p. 716-720 https://doi.org/10.1088/0964-1726/6/6/008	journal	December 1997
Suppression of transverse-mode spurious responses for saw resonators on SiO₂/Al/LiNbO₃ structure by selective removal of SiO₂ Nakamura, H.; Nakanishi, H.; Goto, R. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Vol. 58, Issue 10, p. 2188-2193 https://doi.org/10.1109/TUFFC.2011.2068	journal	October 2011
SAW-grade SiO₂ for advanced microfluidic devices Winkler, Andreas; Menzel, Siegfried; Schmidt, Hagen SPIE Europe Microtechnologies for the New Millennium https://doi.org/10.1117/12.822290	conference	May 2009
Guided Shear Horizontal Surface Acoustic Wave Sensors for Chemical and Biochemical Detection in Liquids Josse, Fabien; Bender, Florian; Cernosek, Richard W. Analytical Chemistry, Vol. 73, Issue 24, p. 5937-5944 https://doi.org/10.1021/ac010859e	journal	December 2001
Sensors based on shear-horizontal surface acoustic waves in layered quartz/SiO₂ and LiTaO₃SiO₂ structures Hermann, F.; Weihnacht, M. 1999 IEEE Ultrasonics Symposium https://doi.org/10.1109/ULTSYM.1999.849431	conference	January 1999

Cited By (1)

Miniature acoustic wave lysis system and uses thereof Branch, Darren W.; Vreeland, Erika; Smith, Gennifer Tanabe https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9512421 US Patent Document 9,512,421	patent	December 2016

Similar Records

Detection of bioagents using a shear horizontal surface acoustic wave biosensor

Patent · Tue Jul 24 00:00:00 EDT 2018 · OSTI ID:1130065

Larson, Richard S.; Hjelle, Brian; Hall, Pam R.; +6 more

Handheld Biosensor for COVID-19 Screening

Technical Report · Tue Sep 01 00:00:00 EDT 2020 · OSTI ID:1130065

Branch, Darren W.; Hayes, Dulce C.; Ricken, James Brice

Shear horizontal surface acoustic wave microsensor for Class A viral and bacterial detection.

Technical Report · Wed Oct 01 00:00:00 EDT 2008 · OSTI ID:1130065

Branch, Darren W; Huber, Dale L; Brozik, Susan Marie; +1 more

Related Subjects

47 OTHER INSTRUMENTATION

Title: Detection of bioagents using a shear horizontal surface acoustic wave biosensor

Citation Formats

References (32)

Cited By (1)

Similar Records

Related Subjects