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Title: Monomeric α-Synuclein Binds Congo Red Micelles in a Disordered Manner

Journal Article · · Biochemistry
DOI:https://doi.org/10.1021/bi201435d· OSTI ID:1123330
 [1];  [1];  [1]
  1. Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, United States
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Sponsoring Organization:
USDOE
OSTI ID:
1123330
Journal Information:
Biochemistry, Journal Name: Biochemistry Vol. 51 Journal Issue: 2; ISSN 0006-2960
Publisher:
American Chemical SocietyCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 31 works
Citation information provided by
Web of Science

References (45)

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The client protein p53 adopts a molten globule–like state in the presence of Hsp90 journal April 2011
Approaches to discovery and characterization of inhibitors of amyloid β-peptide polymerization journal July 2000
α-Synuclein-synaptosomal membrane interactions: Implications for fibrillogenesis journal July 2004
Structural Characterization of Flexible Proteins Using Small-Angle X-ray Scattering journal May 2007
A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening journal April 2002
Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected] journal April 1994
The Association of α-Synuclein with Membranes Affects Bilayer Structure, Stability, and Fibril Formation journal July 2003
Improved Fitting of Solution X-ray Scattering Data to Macromolecular Structures and Structural Ensembles by Explicit Water Modeling journal November 2010
Structural Aspects of Congo Red as an Inhibitor of Protease-Resistant Prion Protein Formation journal December 1998
Disulfide Bond Isomerization in Basic Pancreatic Trypsin Inhibitor:  Multisite Chemical Exchange Quantified by CPMG Relaxation Dispersion and Chemical Shift Modeling journal November 2003
Is Congo Red an Amyloid-specific Dye? journal June 2001
Congophilicity (Congo red affinity) of different β2-microglobulin conformations characterized by dye affinity capillary electrophoresis journal October 2000
Congo Red Populates Partially Unfolded States of an Amyloidogenic Protein to Enhance Aggregation and Amyloid Fibril Formation journal March 2003
α-Synuclein oligomerization: a role for lipids? journal October 2003
Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water* journal January 2000
Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy journal July 2009
Studies on the aggregation of dyes in aqueo us solutions journal December 1970
Small-molecule aggregates inhibit amyloid polymerization journal January 2008
Histidine residues underlie Congo red binding to Aβ analogs journal January 2000
Lipid Binding Inhibits α-Synuclein Fibril Formation journal May 2003
A phase cycle scheme that significantly suppresses offset-dependent artifacts in the R2-CPMG 15N relaxation experiment journal November 2004
Identification of Protein-Mediated Indirect Noe Effects in a Disaccharide-Fab′ Complex by Transferred ROESY journal February 1995
A Specific Mechanism of Nonspecific Inhibition journal August 2003
Measurement of Slow (μs−ms) Time Scale Dynamics in Protein Side Chains by 15 N Relaxation Dispersion NMR Spectroscopy:  Application to Asn and Gln Residues in a Cavity Mutant of T4 Lysozyme journal February 2001
From The Cover: Release of long-range tertiary interactions potentiates aggregation of natively unstructured  -synuclein journal January 2005
Screening Congo Red and its analogues for their ability to prevent the formation of PrP-res in scrapie-infected cells journal April 2000
Exposure to Long Chain Polyunsaturated Fatty Acids Triggers Rapid Multimerization of Synucleins journal November 2001
Small Molecule Inhibitors of α-Synuclein Filament Assembly † journal May 2006
The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding journal October 2010
The Static Magnetic Field Dependence of Chemical Exchange Linebroadening Defines the NMR Chemical Shift Time Scale journal March 2000
Amyloid probes based on Congo Red distinguish between fibrils comprising different peptides journal May 1996
On the Mechanism of Nonspecific Inhibitors of Protein Aggregation: Dissecting the Interactions of α-Synuclein with Congo Red and Lacmoid journal August 2009
Rapid Anionic Micelle-mediated α-Synuclein Fibrillization in Vitro journal September 2003
Solution Conformation, Backbone Dynamics and Lipid Interactions of the Intrinsically Unstructured Malaria Surface Protein MSP2 journal May 2008
Direct Measurements of the Dissociation-Rate Constant for Inhibitor-Enzyme Complexes via the T1ρ and T2 (CPMG) Methods journal July 1994
Characterization of α-Synuclein Interactions with Selected Aggregation-Inhibiting Small Molecules journal March 2008
Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes journal April 1998
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Kinetics of Amyloid β Monomer-to-Oligomer Exchange by NMR Relaxation journal July 2010
Quantification of the calcium-induced secondary structural changes in the regulatory domain of troponin-C journal November 1994

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