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Title: Structural insights into gene repression by the orphan nuclear receptor SHP

Authors:
; ; ; ; ; ; ; ;  [1]
  1. Van Andel
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
FOREIGNOTHERHHMI
OSTI Identifier:
1118048
Resource Type:
Journal Article
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America
Additional Journal Information:
Journal Volume: 111; Journal Issue: (2) ; 01, 2014; Journal ID: ISSN 0027-8424
Publisher:
National Academy of Sciences, Washington, DC (United States)
Country of Publication:
United States
Language:
ENGLISH

Citation Formats

Zhi, Xiaoyong, Zhou, X. Edward, He, Yuanzheng, Zechner, Christoph, Suino-Powell, Kelly M., Kliewer, Steven A., Melcher, Karsten, Mangelsdorf, David J., Xu, H. Eric, Chinese Aca. Sci.), and UTSMC). Structural insights into gene repression by the orphan nuclear receptor SHP. United States: N. p., 2014. Web. doi:10.1073/pnas.1322827111.
Zhi, Xiaoyong, Zhou, X. Edward, He, Yuanzheng, Zechner, Christoph, Suino-Powell, Kelly M., Kliewer, Steven A., Melcher, Karsten, Mangelsdorf, David J., Xu, H. Eric, Chinese Aca. Sci.), & UTSMC). Structural insights into gene repression by the orphan nuclear receptor SHP. United States. doi:10.1073/pnas.1322827111.
Zhi, Xiaoyong, Zhou, X. Edward, He, Yuanzheng, Zechner, Christoph, Suino-Powell, Kelly M., Kliewer, Steven A., Melcher, Karsten, Mangelsdorf, David J., Xu, H. Eric, Chinese Aca. Sci.), and UTSMC). Thu . "Structural insights into gene repression by the orphan nuclear receptor SHP". United States. doi:10.1073/pnas.1322827111.
@article{osti_1118048,
title = {Structural insights into gene repression by the orphan nuclear receptor SHP},
author = {Zhi, Xiaoyong and Zhou, X. Edward and He, Yuanzheng and Zechner, Christoph and Suino-Powell, Kelly M. and Kliewer, Steven A. and Melcher, Karsten and Mangelsdorf, David J. and Xu, H. Eric and Chinese Aca. Sci.) and UTSMC)},
abstractNote = {},
doi = {10.1073/pnas.1322827111},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
issn = {0027-8424},
number = (2) ; 01, 2014,
volume = 111,
place = {United States},
year = {2014},
month = {10}
}

Works referenced in this record:

A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP
journal, May 2002


Interaction of the Corepressor Alien with DAX-1 Is Abrogated by Mutations of DAX-1 Involved in Adrenal Hypoplasia Congenita
journal, March 2000

  • Altincicek, Boran; Tenbaum, Stephan P.; Dressel, Uwe
  • Journal of Biological Chemistry, Vol. 275, Issue 11
  • DOI: 10.1074/jbc.275.11.7662

A gate–latch–lock mechanism for hormone signalling by abscisic acid receptors
journal, November 2009

  • Melcher, Karsten; Ng, Ley-Moy; Zhou, X. Edward
  • Nature, Vol. 462, Issue 7273
  • DOI: 10.1038/nature08613

Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors
journal, March 2006


Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
journal, June 1995

  • Bourguet, William; Ruff, Marc; Chambon, Pierre
  • Nature, Vol. 375, Issue 6530
  • DOI: 10.1038/375377a0

Dual Mechanisms for Repression of the Monomeric Orphan Receptor Liver Receptor Homologous Protein-1 by the Orphan Small Heterodimer Partner
journal, October 2001

  • Lee, Yoon-Kwang; Moore, David D.
  • Journal of Biological Chemistry, Vol. 277, Issue 4
  • DOI: 10.1074/jbc.M105161200

Role of an mSin3A-Swi/Snf Chromatin Remodeling Complex in the Feedback Repression of Bile Acid Biosynthesis by SHP
journal, August 2004


A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function
journal, January 2007

  • Takezawa, Shinichiro; Yokoyama, Atsushi; Okada, Maiko
  • The EMBO Journal, Vol. 26, Issue 3
  • DOI: 10.1038/sj.emboj.7601548

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
journal, September 1998

  • Brünger, A. T.; Adams, P. D.; Clore, G. M.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 54, Issue 5
  • DOI: 10.1107/S0907444998003254

An Orphan Nuclear Hormone Receptor That Lacks a DNA Binding Domain and Heterodimerizes with Other Receptors
journal, May 1996


Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα
journal, February 2002

  • Xu, H. Eric; Stanley, Thomas B.; Montana, Valerie G.
  • Nature, Vol. 415, Issue 6873
  • DOI: 10.1038/415813a

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
journal, September 2000


Improved methods for building protein models in electron density maps and the location of errors in these models
journal, March 1991

  • Jones, T. A.; Zou, J. Y.; Cowan, S. W.
  • Acta Crystallographica Section A Foundations of Crystallography, Vol. 47, Issue 2, p. 110-119
  • DOI: 10.1107/S0108767390010224

Asymmetry in the PPARγ/RXRα Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors
journal, March 2000


The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1
journal, November 2008

  • Sablin, E. P.; Woods, A.; Krylova, I. N.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 47
  • DOI: 10.1073/pnas.0808936105

Efficient anisotropic refinement of macromolecular structures using FFT
journal, January 1999

  • Murshudov, Garib N.; Vagin, Alexei A.; Lebedev, Andrey
  • Acta Crystallographica Section D Biological Crystallography, Vol. 55, Issue 1
  • DOI: 10.1107/S090744499801405X

The nuclear receptor superfamily: The second decade
journal, December 1995


Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix
journal, September 2000


Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated Receptor
journal, September 2008


The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor
journal, November 2010

  • Zhou, X. Edward; Suino-Powell, Kelly M.; Xu, Yong
  • Journal of Biological Chemistry, Vol. 286, Issue 4
  • DOI: 10.1074/jbc.M110.168740

Transcriptional corepression by SHP: molecular mechanisms and physiological consequences
journal, December 2005

  • Båvner, Ann; Sanyal, Sabyasachi; Gustafsson, Jan-Åke
  • Trends in Endocrinology & Metabolism, Vol. 16, Issue 10
  • DOI: 10.1016/j.tem.2005.10.005

Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner
journal, June 2005

  • Li, Y.; Choi, M.; Suino, K.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 27
  • DOI: 10.1073/pnas.0501204102

Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation
journal, April 2010

  • Chanda, Dipanjan; Xie, Yuan-Bin; Choi, Hueng-Sik
  • Nucleic Acids Research, Vol. 38, Issue 14
  • DOI: 10.1093/nar/gkq227

Novel Polymorphisms of Nuclear Receptor SHP Associated with Functional and Structural Changes
journal, June 2010

  • Zhou, Taofeng; Zhang, Yuxia; Macchiarulo, Antonio
  • Journal of Biological Chemistry, Vol. 285, Issue 32
  • DOI: 10.1074/jbc.M110.133280

Unveiling hidden features of orphan nuclear receptors: The case of the small heterodimer partner (SHP)
journal, March 2006

  • Macchiarulo, Antonio; Rizzo, Giovanni; Costantino, Gabriele
  • Journal of Molecular Graphics and Modelling, Vol. 24, Issue 5
  • DOI: 10.1016/j.jmgm.2005.09.016

The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation
journal, September 2013


Multiple Binding Modes between HNF4α and the L XX LL Motifs of PGC-1α Lead to Full Activation
journal, October 2009

  • Rha, Geun Bae; Wu, Guangteng; Shoelson, Steven E.
  • Journal of Biological Chemistry, Vol. 284, Issue 50
  • DOI: 10.1074/jbc.M109.052506

Novel receptor interaction and repression domains in the orphan receptor SHP.
journal, December 1997

  • Seol, W.; Chung, M.; Moore, D. D.
  • Molecular and Cellular Biology, Vol. 17, Issue 12
  • DOI: 10.1128/MCB.17.12.7126

Activation of Nuclear Receptors
journal, July 2003


A Novel Rb- and p300-Binding Protein Inhibits Transactivation by MyoD
journal, December 2000


Dynamic Stabilization of Nuclear Receptor Ligand Binding Domains by Hormone or Corepressor Binding
journal, August 2000


Cells Degrade a Novel Inhibitor of Differentiation with E1A-Like Properties upon Exiting the Cell Cycle
journal, December 2000


Adamantyl-Substituted Retinoid-Related Molecules Bind Small Heterodimer Partner and Modulate the Sin3A Repressor
journal, January 2007


Structural Analyses Reveal Phosphatidyl Inositols as Ligands for the NR5 Orphan Receptors SF-1 and LRH-1
journal, February 2005


Loss of Nuclear Receptor SHP Impairs but Does Not Eliminate Negative Feedback Regulation of Bile Acid Synthesis
journal, June 2002


Differential Role of the Loop Region between Helices H6 and H7 within the Orphan Nuclear Receptors Small Heterodimer Partner and DAX-1
journal, May 2004

  • Park, Yun-Yong; Kim, Han-Jong; Kim, Joon-Young
  • Molecular Endocrinology, Vol. 18, Issue 5
  • DOI: 10.1210/me.2003-0339

Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes
journal, December 2011

  • Zhi, Xiaoyong; Zhou, X. Edward; Melcher, Karsten
  • Journal of Biological Chemistry, Vol. 287, Issue 7
  • DOI: 10.1074/jbc.M111.315242

Structural Basis for Hydroxycholesterols as Natural Ligands of Orphan Nuclear Receptor RORγ
journal, May 2010

  • Jin, Lihua; Martynowski, Dariusz; Zheng, Songyang
  • Molecular Endocrinology, Vol. 24, Issue 5
  • DOI: 10.1210/me.2009-0507

SMILE, a new orphan nuclear receptor SHP-interacting protein, regulates SHP-repressed estrogen receptor transactivation
journal, November 2008

  • Xie, Yuan-Bin; Lee, Ok-Hee; Nedumaran, Balachandar
  • Biochemical Journal, Vol. 416, Issue 3
  • DOI: 10.1042/BJ20080782

Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1
journal, May 2006


A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
journal, September 2000


Nuclear Receptors HNF4α and LRH-1 Cooperate in Regulating Cyp7a1 in Vivo
journal, October 2012

  • Kir, Serkan; Zhang, Yuan; Gerard, Robert D.
  • Journal of Biological Chemistry, Vol. 287, Issue 49
  • DOI: 10.1074/jbc.M112.421834

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
journal, October 2005


Molecular recognition of parathyroid hormone by its G protein-coupled receptor
journal, March 2008

  • Pioszak, Augen A.; Xu, H. Eric
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 13
  • DOI: 10.1073/pnas.0801027105

Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis
journal, September 2007

  • Sanyal, S.; Bavner, A.; Haroniti, A.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 40
  • DOI: 10.1073/pnas.0706736104

Redundant Pathways for Negative Feedback Regulation of Bile Acid Production
journal, June 2002