Regulating the ethylene response of a plant by modulation of F-box proteins

Guo, Hongwei; Ecker, Joseph R

Title: Regulating the ethylene response of a plant by modulation of F-box proteins

Patent · Tue Jan 07 00:00:00 EST 2014

OSTI ID:1113807

Guo, Hongwei ^[1]; Ecker, Joseph R ^[2]

Beijing, CN
Carlsbad, CA

The relationship between F-box proteins and proteins invovled in the ethylene response in plants is described. In particular, F-box proteins may bind to proteins involved in the ethylene response and target them for degradation by the ubiquitin/proteasome pathway. The transcription factor EIN3 is a key transcription factor mediating ethylne-regulated gene expression and morphological responses. EIN3 is degraded through a ubiquitin/proteasome pathway mediated by F-box proteins EBF1 and EBF2. The link between F-box proteins and the ethylene response is a key step in modulating or regulating the response of a plant to ethylene. Described herein are transgenic plants having an altered sensitivity to ethylene, and methods for making transgenic plant haing an althered sensitivity to ethylene by modulating the level of activity of F-box proteins. Methods of altering the ethylene response in a plant by modulating the activity or expression of an F-box protein are described. Also described are methods of identifying compounds that modulate the ethylene response in plants by modulating the level of F-box protein expression or activity.

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Research Organization:: Salk Institute for Biological Studies, La Jolla, CA, USA

Sponsoring Organization:: USDOE

DOE Contract Number:: FG03-00ER15113

Assignee:: Salk Institute for Biological Studies (La Jolla, CA)

Patent Number(s):: 8,624,081

Application Number:: 13/015,333

OSTI ID:: 1113807

Resource Relation:: Patent File Date: 2011 Jan 27

Country of Publication:: United States

Language:: English

References (58)

Regulating the ethylene response of a plant by modulation of F-box proteins Guo, Hongwei; Ecker, Joseph R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7655835 US Patent Document 7,655,835	patent	February 2010
Homologs of SCF ubiquitin-ligase complex component GRR1 Allen, Stephen M.; Helentjaris, Timothy G. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20010034059 US Patent Application 09/727801; 20010034059	patent-application	October 2001
Regulating the ethylene response of a plant by modulation of F-box proteins Guo, Hongwei; Ecker, Joseph R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060200875 US Patent Application 11/298286; 20060200875	patent-application	September 2006
Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana Alonso, J. M.; Stepanova, Anna N.; Leisse, Thomas J. Science, Vol. 301, Issue 5633, p. 653-657 https://doi.org/10.1126/science.1086391	journal	August 2003
EIN2, a Bifunctional Transducer of Ethylene and Stress Responses in Arabidopsis Alonso, J. M. Science, Vol. 284, Issue 5423 https://doi.org/10.1126/science.284.5423.2148	journal	June 1999
A 126 bp fragment of a plant histone gene promoter confers preferential expression in meristems of transgenic Arabidopsis Atanassova, Rossitza; Chaubet, Nicole; Gigot, Claude The Plant Journal, Vol. 2, Issue 3 https://doi.org/10.1111/j.1365-313X.1992.00291.x	journal	May 1992
[33] Expression and secretion vectors for yeast Bitter, Grant A.; Egan, Kevin M.; Koski, Raymond A. Recombinant DNA Part D, Vol. 153, p. 516-544 https://doi.org/10.1016/0076-6879(87)53076-2	book	January 1987
Insensitivity to Ethylene Conferred by a Dominant Mutation in Arabidopsis thaliana Bleecker, A. B.; Estelle, M. A.; Somerville, C. Science, Vol. 241, Issue 4869 https://doi.org/10.1126/science.241.4869.1086	journal	August 1988
Ethylene: A Gaseous Signal Molecule in Plants Bleecker, Anthony B.; Kende, Hans Annual Review of Cell and Developmental Biology, Vol. 16, Issue 1 https://doi.org/10.1146/annurev.cellbio.16.1.1	journal	November 2000
Expression of a bacterial gene in plants by using a viral vector Brisson, N.; Paszkowski, J.; Penswick, J. R. Nature, Vol. 310, Issue 5977 https://doi.org/10.1038/310511a0	journal	August 1984
Light-regulated expression of a pea ribulose-1,5-bisphosphate carboxylase small subunit gene in transformed plant cells Broglie, R.; Coruzzi, G.; Fraley, R. Science, Vol. 224, Issue 4651 https://doi.org/10.1126/science.6719112	journal	May 1984
Arabidopsis ethylene-response gene ETR1: similarity of product to two-component regulators Chang, C.; Kwok, S.; Bleecker, A. Science, Vol. 262, Issue 5133 https://doi.org/10.1126/science.8211181	journal	October 1993
Localization of the Ethylene Receptor ETR1 to the Endoplasmic Reticulum of Arabidopsis Chen, Yi-Feng; Randlett, Melynda D.; Findell, Jennifer L. Journal of Biological Chemistry, Vol. 277, Issue 22 https://doi.org/10.1074/jbc.M201286200	journal	March 2002
SCF and Cullin/RING H2-Based Ubiquitin Ligases Deshaies, R. J. Annual Review of Cell and Developmental Biology, Vol. 15, Issue 1 https://doi.org/10.1146/annurev.cellbio.15.1.435	journal	November 1999
The ethylene signal transduction pathway in plants Science, Vol. 268, Issue 5211 https://doi.org/10.1126/science.7732375	journal	May 1995
Late embryogenesis-abundant genes encoding proteins with different numbers of hydrophilic repeats are regulated differentially by abscisic acid and osmotic stress [published erratum appears in Plant J 1992 Jul;2(4):639] Espelund, M.; Saeboe-Larssen, S.; Hughes, Dw The Plant Journal, Vol. 2, Issue 2 https://doi.org/10.1046/j.1365-313X.1992.t01-46-00999.x	journal	March 1992
Ubiquitin-mediated proteolysis in plant hormone signal transduction Frugis, Giovanna; Chua, Nam-Hai Trends in Cell Biology, Vol. 12, Issue 7, p. 308-311 https://doi.org/10.1016/S0962-8924(02)02308-5	journal	July 2002
The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis Gagne, J. M.; Downes, B. P.; Shiu, S.-H. Proceedings of the National Academy of Sciences, Vol. 99, Issue 17, p. 11519-11524 https://doi.org/10.1073/pnas.162339999	journal	August 2002
Histidine kinase activity of the ETR1 ethylene receptor from Arabidopsis Gamble, R. L.; Coonfield, M. L.; Schaller, G. E. Proceedings of the National Academy of Sciences, Vol. 95, Issue 13 https://doi.org/10.1073/pnas.95.13.7825	journal	June 1998
Auxin regulates SCFTIR1-dependent degradation of AUX/IAA proteins Gray, William M.; Kepinski, Stefan; Rouse, Dean Nature, Vol. 414, Issue 6861 https://doi.org/10.1038/35104500	journal	November 2001
SUB1, an Arabidopsis Ca2+-Binding Protein Involved in Cryptochrome and Phytochrome Coaction Guo, H. Science, Vol. 291, Issue 5503 https://doi.org/10.1126/science.291.5503.487	journal	January 2001
Plant Responses to Ethylene Gas Are Mediated by SCF^EBF1/EBF2-Dependent Proteolysis of EIN3 Transcription Factor Guo, Hongwei; Ecker, Joseph R Cell, Vol. 115, Issue 6, p. 667-677 https://doi.org/10.1016/S0092-8674(03)00969-3	journal	December 2003
Protein tolerance to random amino acid change Guo, H. H.; Choe, J.; Loeb, L. A. Proceedings of the National Academy of Sciences, Vol. 101, Issue 25, p. 9205-9210 https://doi.org/10.1073/pnas.0403255101	journal	June 2004
Upstream sequences required for efficient expression of a soybean heat shock gene. Gurley, W. B.; Czarnecka, E.; Nagao, R. T. Molecular and Cellular Biology, Vol. 6, Issue 2, p. 559-565 https://doi.org/10.1128/MCB.6.2.559	journal	February 1986
Exploiting the triple response of Arabidopsis to identify ethylene-related mutants. Guzmán, P.; Ecker, J. R. The Plant Cell, Vol. 2, Issue 6 https://doi.org/10.1105/tpc.2.6.513	journal	June 1990
The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis He, J.-X.; Gendron, J. M.; Yang, Y. Proceedings of the National Academy of Sciences, Vol. 99, Issue 15, p. 10185-10190 https://doi.org/10.1073/pnas.152342599	journal	July 2002
Plant Development: Regulation by Protein Degradation Hellmann, H. Science, Vol. 297, Issue 5582 https://doi.org/10.1126/science.1072831	journal	August 2002
Ubiquitin-Dependent Protein Degradation Hochstrasser, Mark Annual Review of Genetics, Vol. 30, Issue 1 https://doi.org/10.1146/annurev.genet.30.1.405	journal	December 1996
EIN4 and ERS2 Are Members of the Putative Ethylene Receptor Gene Family in Arabidopsis Hua, Jian; Sakai, Hajime; Nourizadeh, Saeid The Plant Cell, Vol. 10, Issue 8 https://doi.org/10.1105/tpc.10.8.1321	journal	August 1998
Meristem-specific gene expression directed by the promoter of the S-phase-specific gene, cyc07, in transgenic Arabidopsis Ito, Masaki; Sato, Tsutomu; Fukuda, Hiroo Plant Molecular Biology, Vol. 24, Issue 6 https://doi.org/10.1007/BF00014441	journal	March 1994
THE ETHYLENE GAS SIGNAL TRANSDUCTION PATHWAY: A Molecular Perspective Johnson, Phoebe R.; Ecker, Joseph R. Annual Review of Genetics, Vol. 32, Issue 1 https://doi.org/10.1146/annurev.genet.32.1.227	journal	December 1998
A new, structurally nonredundant, diverse data set of protein-protein interfaces and its implications Keskin, Ozlem; Tsai, Chung-Jung; Wolfson, Haim Protein Science, Vol. 13, Issue 4, p. 1043-1055 https://doi.org/10.1110/ps.03484604	journal	April 2004
High-velocity microprojectiles for delivering nucleic acids into living cells Klein, T. M.; Wolf, E. D.; Wu, R. Nature, Vol. 327, Issue 6117, p. 70-73 https://doi.org/10.1038/327070a0	journal	May 1987
Transformation of Microbes, Plants and Animals by Particle Bombardment Klein, Theodore M.; Arentzen, Rene; Lewis, Paul A. Nature Biotechnology, Vol. 10, Issue 3, p. 286-291 https://doi.org/10.1038/nbt0392-286	journal	March 1992
The Arabidopsis eer1 Mutant Has Enhanced Ethylene Responses in the Hypocotyl and Stem Larsen, Paul B.; Chang, Caren Plant Physiology, Vol. 125, Issue 2 https://doi.org/10.1104/pp.125.2.1061	journal	February 2001
Proteasome inhibitors: valuable new tools for cell biologists Lee, Do Hee; Goldberg, Alfred L Trends in Cell Biology, Vol. 8, Issue 10, p. 397-403 https://doi.org/10.1016/S0962-8924(98)01346-4	journal	October 1998
A postgermination developmental arrest checkpoint is mediated by abscisic acid and requires the ABI5 transcription factor in Arabidopsis Lopez-Molina, L.; Mongrand, S.; Chua, N.-H. Proceedings of the National Academy of Sciences, Vol. 98, Issue 8, p. 4782-4787 https://doi.org/10.1073/pnas.081594298	journal	April 2001
Techniques for using antisense oligodeoxyribonucleotides to study gene expression Marcus-Sekura, Carol J. Analytical Biochemistry, Vol. 172, Issue 2, p. 289-295 https://doi.org/10.1016/0003-2697(88)90447-2	journal	August 1988
Spatial pattern of cdc2 expression in relation to meristem activity and cell proliferation during plant development. Martinez, M. C.; Jorgensen, J. E.; Lawton, M. A. Proceedings of the National Academy of Sciences, Vol. 89, Issue 16 https://doi.org/10.1073/pnas.89.16.7360	journal	August 1992
The Arabidopsis SLEEPY1 Gene Encodes a Putative F-Box Subunit of an SCF E3 Ubiquitin Ligase McGinnis, Karen M.; Thomas, Stephen G.; Soule, Jonathan D. The Plant Cell, Vol. 15, Issue 5 https://doi.org/10.1105/tpc.010827	journal	April 2003
Molecular cloning and characterization of genes expressed in shoot apical meristems. Medford, J. I.; Elmer, J. S.; Klee, H. J. The Plant Cell, Vol. 3, Issue 4 https://doi.org/10.1105/tpc.3.4.359	journal	April 1991
Copper-controllable gene expression system for whole plants. Mett, V. L.; Lochhead, L. P.; Reynolds, P. H. Proceedings of the National Academy of Sciences, Vol. 90, Issue 10 https://doi.org/10.1073/pnas.90.10.4567	journal	May 1993
Identification of DNA sequences required for activity of the cauliflower mosaic virus 35S promoter Odell, Joan T.; Nagy, Ferenc; Chua, Nam-Hai Nature, Vol. 313, Issue 6005, p. 810-812 https://doi.org/10.1038/313810a0	journal	February 1985
A MAPK pathway mediates ethylene signaling in plants Ouaked, F. The EMBO Journal, Vol. 22, Issue 6 https://doi.org/10.1093/emboj/cdg131	journal	March 2003
EIN3-Dependent Regulation of Plant Ethylene Hormone Signaling by Two Arabidopsis F Box Proteins Potuschak, Thomas; Lechner, Esther; Parmentier, Yves Cell, Vol. 115, Issue 6, p. 679-689 https://doi.org/10.1016/S0092-8674(03)00968-1	journal	December 2003
Accumulation of Phosphorylated Repressor for Gibberellin Signaling in an F-box Mutant Sasaki, A. Science, Vol. 299, Issue 5614 https://doi.org/10.1126/science.1081077	journal	March 2003
A steroid-inducible gene expression system for plant cells. Schena, M.; Lloyd, A. M.; Davis, R. W. Proceedings of the National Academy of Sciences, Vol. 88, Issue 23 https://doi.org/10.1073/pnas.88.23.10421	journal	December 1991
Heat-inducible hygromycin resistance in transgenic tobacco Severin, Klaus; Sch�ffl, Fritz Plant Molecular Biology, Vol. 15, Issue 6 https://doi.org/10.1007/BF00039423	journal	December 1990
Nuclear events in ethylene signaling: a transcriptional cascade mediated by ETHYLENE-INSENSITIVE3 and ETHYLENE-RESPONSE-FACTOR1 Solano, R.; Stepanova, A.; Chao, Q. Genes & Development, Vol. 12, Issue 23 https://doi.org/10.1101/gad.12.23.3703	journal	December 1998
Ethylene signaling: from mutants to molecules Stepanova, Anna N.; Ecker, Joseph R. Current Opinion in Plant Biology, Vol. 3, Issue 5, p. 353-360 https://doi.org/10.1016/S1369-5266(00)00096-0	journal	October 2000
From structure to function: Approaches and limitations Thornton, Janet M.; Todd, Annabel E.; Milburn, Duncan Nature Structural Biology, Vol. 7, p. 991-994 https://doi.org/10.1038/80784	journal	November 2000
The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit β-globin DNA Wallace, R. Bruce; Johnson, Merrie Jo; Hirose, Tadaaki Nucleic Acids Research, Vol. 9, Issue 4 https://doi.org/10.1093/nar/9.4.879	journal	January 1981
Ethylene Biosynthesis and Signaling Networks Wang, Kevin L. -C.; Li, Hai; Ecker, Joseph R. The Plant Cell, Vol. 14, Issue suppl 1 https://doi.org/10.1105/tpc.001768	journal	May 2002
Additivity of mutational effects in proteins Wells, James A. Biochemistry, Vol. 29, Issue 37, p. 8509-8517 https://doi.org/10.1021/bi00489a001	journal	September 1990
ORE9, an F-Box Protein That Regulates Leaf Senescence in Arabidopsis Woo, H. R. THE PLANT CELL ONLINE, Vol. 13, Issue 8 https://doi.org/10.1105/tpc.13.8.1779	journal	August 2001
COI1: An Arabidopsis Gene Required for Jasmonate-Regulated Defense and Fertility Xie, D. Science, Vol. 280, Issue 5366 https://doi.org/10.1126/science.280.5366.1091	journal	May 1998
F-box proteins in Arabidopsis Xiao, Wenyan; Jang, Jyan-Chyun Trends in Plant Science, Vol. 5, Issue 11, p. 454-457 https://doi.org/10.1016/S1360-1385(00)01769-6	journal	November 2000
BES1 Accumulates in the Nucleus in Response to Brassinosteroids to Regulate Gene Expression and Promote Stem Elongation Yin, Yanhai; Wang, Zhi-Yong; Mora-Garcia, Santiago Cell, Vol. 109, Issue 2, p. 181-191 https://doi.org/10.1016/S0092-8674(02)00721-3	journal	April 2002

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