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Title: A metabolomics and mouse models approach to study inflammatory and immune responses to radiation

Abstract

The three-year project entitled "A Metabolomics and Mouse Models Approach to Study Inflammatory and Immune Responses to Radiation" was initiated in September 2009. The overall objectives of this project were to investigate the acute and persistent effects of low dose radiation on T cell lymphocyte function and physiology, as well the contributions of these cells to radiation-induced inflammatory responses. Inflammation after ionizing radiation (IR), even at low doses, may impact a variety of disease processes, including infectious disease, cardiovascular disease, cancer, and other potentially inflammatory disorders. There were three overall specific aims: 1. To investigate acute and persistent effects of low dose radiation on T cell subsets and function; 2. A genetic approach with mouse models to investigate p38 MAPK pathways that are involved in radiation-induced inflammatory signaling; 3. To investigate the effect of radiation quality on the inflammatory response. We have completed the work proposed in these aims.

Authors:
 [1];  [1]
  1. Georgetown Univ., Washington, DC (United States)
Publication Date:
Research Org.:
Georgetown Univ., Washington, DC (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1108439
Report Number(s):
DOE-GU-0002345
DOE Contract Number:  
SC0002345
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

Fornace, Albert J., and Li, Henghong. A metabolomics and mouse models approach to study inflammatory and immune responses to radiation. United States: N. p., 2013. Web.
Fornace, Albert J., & Li, Henghong. A metabolomics and mouse models approach to study inflammatory and immune responses to radiation. United States.
Fornace, Albert J., and Li, Henghong. Mon . "A metabolomics and mouse models approach to study inflammatory and immune responses to radiation". United States.
@article{osti_1108439,
title = {A metabolomics and mouse models approach to study inflammatory and immune responses to radiation},
author = {Fornace, Albert J. and Li, Henghong},
abstractNote = {The three-year project entitled "A Metabolomics and Mouse Models Approach to Study Inflammatory and Immune Responses to Radiation" was initiated in September 2009. The overall objectives of this project were to investigate the acute and persistent effects of low dose radiation on T cell lymphocyte function and physiology, as well the contributions of these cells to radiation-induced inflammatory responses. Inflammation after ionizing radiation (IR), even at low doses, may impact a variety of disease processes, including infectious disease, cardiovascular disease, cancer, and other potentially inflammatory disorders. There were three overall specific aims: 1. To investigate acute and persistent effects of low dose radiation on T cell subsets and function; 2. A genetic approach with mouse models to investigate p38 MAPK pathways that are involved in radiation-induced inflammatory signaling; 3. To investigate the effect of radiation quality on the inflammatory response. We have completed the work proposed in these aims.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Dec 02 00:00:00 EST 2013},
month = {Mon Dec 02 00:00:00 EST 2013}
}

Technical Report:
Other availability
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