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Producing dicarboxylic acids using polyketide synthases

Patent ·
OSTI ID:1107783
The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.
Research Organization:
LBNL (Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States))
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231;
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
8,569,023
Application Number:
12/922,204
OSTI ID:
1107783
Country of Publication:
United States
Language:
English

References (4)

Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units journal February 2001
A chain initiation factor common to both modular and aromatic polyketide synthases journal September 1999
Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway journal June 2007
Precursor-Directed Biosynthesis of Erythromycin Analogs by an Engineered Polyketide Synthase journal July 1997

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