Visual-servoing optical microscopy

Callahan, Daniel E; Parvin, Bahram

Visual-servoing optical microscopy

Patent · 01 October 2013

OSTI ID:1107355

Callahan, Daniel E; Parvin, Bahram

The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time; quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells.

Research Organization:: LBNL (Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States))

Sponsoring Organization:: USDOE

DOE Contract Number:: AC03-76SF00098

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 8,548,745

Application Number:: 13/107,601

OSTI ID:: 1107355

Country of Publication:: United States

Language:: English

References (8)

Swelling-activated chloride channels in multidrug-sensitive and -resistant cells. Ehring, G. R.; Osipchuk, Y. V.; Cahalan, M. D. Journal of General Physiology, Vol. 104, Issue 6 https://doi.org/10.1085/jgp.104.6.1129	journal	December 1994
Leginon: a system for fully automated acquisition of 1000 electron micrographs a day Potter, C. S.; Chu, H.; Frey, B. Ultramicroscopy, Vol. 77, Issue 3-4 https://doi.org/10.1016/S0304-3991(99)00043-1	journal	July 1999
A Collaborative Framework for Distributed Microscopy Parvin, B.; Taylor, J.; Cong, G. SC98 - High Performance Networking and Computing Conference, Proceedings of the IEEE/ACM SC98 Conference https://doi.org/10.1109/SC.1998.10050	conference	January 1998
Miniaturized FRET assays and microfluidics: key components for ultra-high-throughput screening Mere, L. Drug Discovery Today, Vol. 4, Issue 8 https://doi.org/10.1016/S1359-6446(99)01377-X	journal	August 1999
Microcomputer-controlled device for delivering hormone stimulation to cell suspensions in perifusion: release of luteinising hormone from sheep pituitary cells McIntosh, J. E. A.; McIntosh, R. P.; Kean, R. J. Medical & Biological Engineering & Computing, Vol. 22, Issue 3 https://doi.org/10.1007/BF02442753	journal	May 1984
Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells. Lewis, R. S.; Cahalan, M. D. Cell Regulation, Vol. 1, Issue 1 https://doi.org/10.1091/mbc.1.1.99	journal	November 1989
Visual servoing for online facilities Parvin, B.; Taylor, J. R.; Callahan, D. E. Computer, Vol. 30, Issue 7 https://doi.org/10.1109/2.596629	journal	July 1997
Intracellular calcium dependence of gene expression in single T lymphocytes. Negulescu, P. A.; Shastri, N.; Cahalan, M. D. Proceedings of the National Academy of Sciences, Vol. 91, Issue 7 https://doi.org/10.1073/pnas.91.7.2873	journal	March 1994

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