Selective high-affinity polydentate ligands and methods of making such
Patent
·
OSTI ID:1093436
This invention provides polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each binds different regions on the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
- Research Organization:
- LLNL (Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States))
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-48
- Assignee:
- Lawrence Livermore National Security, LLC. (Livermore, CA); The Regents of the University of California (Oakland, CA)
- Patent Number(s):
- 8,536,133
- Application Number:
- 12/642,684
- OSTI ID:
- 1093436
- Country of Publication:
- United States
- Language:
- English
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