Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes

Thompson, David N; Apel, William A; Thompson, Vicki S; Ward, Thomas E

Title: Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes

Patent · Tue Jul 23 00:00:00 EDT 2013

OSTI ID:1088690

Thompson, David N; Apel, William A; Thompson, Vicki S; Ward, Thomas E

A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from Alicyclobacillus acidocaldarius and encoding a polypeptide involved in at least partially degrading, cleaving, transporting, metabolizing, or removing polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups; and at least one nucleic acid sequence and/or at least one recombinant nucleic acid encoding a polypeptide involved in fermenting sugar molecules to a product. Additionally, enzymatic and/or proteinaceous extracts may be isolated from one or more genetically modified organisms. The extracts are utilized to convert biomass into a product. Further provided are methods of converting biomass into products comprising: placing the genetically modified organism and/or enzymatic extracts thereof in fluid contact with polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, and/or xylan-, glucan-, galactan-, or mannan-decorating groups.

View Patent

Cite

Export

Save

Research Organization:: Idaho National Laboratory (INL), Idaho Falls, ID (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC07-99ID13727; AC07-05ID14517

Assignee:: Battelle Energy Alliance, LLC (Idaho Falls, ID)

Patent Number(s):: 8,492,114

Application Number:: 12/587,229

OSTI ID:: 1088690

Country of Publication:: United States

Language:: English

References (117)

The first description of an archaeal hemicellulase: the xylanase from Thermococcus zilligii strain AN1 Uhl, Andreas M.; Daniel, Roy M. Extremophiles, Vol. 3, Issue 4, p. 263-267 https://doi.org/10.1007/s007920050126	journal	November 1999
Expression of microbial proteins in plants for production of plants with improved properties Cao, Yongwei; Hinkle, Gregory J.; Slater, Steven C. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030233675 US Patent Application 10/369493; 20030233675	patent-application	December 2003
Process for hydrolyzing starch without pH adjustment Shetty, Jayarama K.; Singley, Eric C.; Strohm, Bruce A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030134395 US Patent Application 10/026288; 20030134395	patent-application	July 2003
The nature of lignocellulosics and their pretreatments for enzymatic hydrolysis Fan, L. T.; Lee, Young-Hyun; Gharpuray, M. M. Microbial Reactions, p. 157-187 https://doi.org/10.1007/3540116982_4	book	January 1982
PCR ligation mutagenesis in transformable streptococci: application and efficiency Lau, Peter C. Y.; Sung, Chang Kyoo; Lee, Janet H. Journal of Microbiological Methods, Vol. 49, Issue 2, p. 193-205 https://doi.org/10.1016/S0167-7012(01)00369-4	journal	April 2002
Conversion of a β-Ketoacyl Synthase to a Malonyl Decarboxylase by Replacement of the Active-Site Cysteine with Glutamine Witkowski, Andrzej; Joshi, Anil K.; Lindqvist, Ylva Biochemistry, Vol. 38, Issue 36, p. 11643-11650 https://doi.org/10.1021/bi990993h	journal	September 1999
Production of a cellulase-free xylanase from agricultural waste materials by a thermotolerant Streptomyces sp. Techapun, Charin; Sinsuwongwat, Suphawat; Poosaran, Naiyatat Biotechnology Letters, Vol. 23, Issue 20, p. 1685-1689 https://doi.org/10.1023/A:1012448229555	journal	October 2001
Glycosylation Engineering: Controlling personalities tame wild sugars on proteins and natural products Borman, STU Chemical & Engineering News Archive, Vol. 84, Issue 36, p. 13-22 https://doi.org/10.1021/cen-v084n036.p013	journal	September 2006
Lignochemicals Hanselmann, K. W.; Mislin, Hans; Bachofen, Reinhard New Trends in Research and Utilization of Solar Energy through Biological Systems, p. 104-117 https://doi.org/10.1007/978-3-0348-6305-6_21	book	January 1982
Probe containing a modified nucleic acid recognizable by specific antibodies and use of this probe to detect and characterize a homologous dna sequence Tchen, Paul; Kourilsky, Philip; Leng, Marc https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5098825 US Patent Document 5,098,825	patent	March 1992
Thermal and acid tolerant beta-xylosidases, genes encoding, related organisms, and methods Thompson, David N.; Thompson, Vicki S.; Schaller, Kastli D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090226978 US Patent Application 12/321636; 20090226978	patent-application	September 2009
Thermophilic Organisms For Conversion Of Lignocellulosic Biomass To Ethanol Shaw, IV, Arthur; Desai, Sunil G.; Lynd, Lee R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090221049 US Patent Application PCT/US07/67941; 20090221049	patent-application	September 2009
Purification and Properties of Acid Stable Xylanases from Aspergillus kawachii Ito, Kiyoshi; Ogasawara, Hironobu; Sugimoto, Takashi Bioscience, Biotechnology, and Biochemistry, Vol. 56, Issue 4, p. 547-550 https://doi.org/10.1271/bbb.56.547	journal	January 1992
Xylanases in bleaching: From an idea to the industry Viikari, Liisa; Kantelinen, Anne; Sundquist, Jorma FEMS Microbiology Reviews, Vol. 13, Issue 2-3, p. 335-350 https://doi.org/10.1111/j.1574-6976.1994.tb00053.x	journal	March 1994
Synthesis of oligosaccharides, glycolipds, and glycoproteins using bacterial glycosyltransferases Johnson, Karl F.; Bezila, Daniel James; Taylor, Diane E. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070148728 US Patent Application PCT/US03/23155; 20070148728	patent-application	June 2007
Isolation and characterization of a new family 42 β-galactosidase from the thermoacidophilic bacterium Alicyclobacillus acidocaldarius: Identification of the active site residues Di Lauro, Barbara; Strazzulli, Andrea; Perugino, Giuseppe Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1784, Issue 2, p. 292-301 https://doi.org/10.1016/j.bbapap.2007.10.013	journal	February 2008
Maltose and Maltodextrin Transport in the Thermoacidophilic Gram-Positive Bacterium Alicyclobacillus acidocaldarius Is Mediated by a High-Affinity Transport System That Includes a Maltose Binding Protein Tolerant to Low pH Hülsmann, A.; Lurz, R.; Scheffel, F. Journal of Bacteriology, Vol. 182, Issue 22, p. 6292-6301 https://doi.org/10.1128/JB.182.22.6292-6301.2000	journal	November 2000
Kenealy, William R.; Jeffries, Thomas W. Biotechnology Letters, Vol. 25, Issue 19, p. 1619-1623 https://doi.org/10.1023/A:1025668031928	journal	October 2003
Xylanase obtained from an anaerobic fungus Cheng, Kuo-Joan; Selinger, Leonard Brent; Liu, Jin-Hao https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5948667 US Patent Document 5,948,667	patent	September 1999
Strand displacement amplification—an isothermal, in vitro DNA amplification technique Walker, G. Terrance; Fraiser, Melinda S.; Schram, James L. Nucleic Acids Research, Vol. 20, Issue 7, p. 1691-1696 https://doi.org/10.1093/nar/20.7.1691	journal	January 1992
Molecular and biotechnological aspects of xylanases Kulkarni, Neeta; Shendye, Abhay; Rao, Mala FEMS Microbiology Reviews, Vol. 23, Issue 4, p. 411-456 https://doi.org/10.1111/j.1574-6976.1999.tb00407.x	journal	July 1999
Comparison of the economics of acid and enzymatic hydrolysis of newsprint Grethlein, Hans E. Biotechnology and Bioengineering, Vol. 20, Issue 4, p. 503-525 https://doi.org/10.1002/bit.260200404	journal	April 1978
Baculovirus systems for the expression of human gene products Luckow, Verne A. Current Opinion in Biotechnology, Vol. 4, Issue 5, p. 564-572 https://doi.org/10.1016/0958-1669(93)90078-B	journal	October 1993
Multiple Chromosomes in Bacteria: The Yin and Yang of trp Gene Localization in Rhodobacter sphaeroides 2.4.1 Mackenzie, Chris; Simmons, Adrian E.; Kaplan, Samuel Genetics, Vol. 153, Issue 2 https://doi.org/10.1093/genetics/153.2.525	journal	October 1999
Continuous cultures of fused cells secreting antibody of predefined specificity Köhler, G.; Milstein, C. Nature, Vol. 256, Issue 5517, p. 495-497 https://doi.org/10.1038/256495a0	journal	August 1975
Genetic disease detection and DNA amplification using cloned thermostable ligase. Barany, F. Proceedings of the National Academy of Sciences, Vol. 88, Issue 1, p. 189-193 https://doi.org/10.1073/pnas.88.1.189	journal	January 1991
Tomato plants that exhibit resistance to botrytis cinerea Gabor, Brad; Frampton, Anna; Bragaloni, Mauro https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030233674 US Patent Application 10/278360; 20030233674	patent-application	December 2003
Thermophilic and thermoacidophilic sugar transporter genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods Thompson, David N.; Apel, William A.; Thompson, Vicki S. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090253205 US Patent Application 12/380554; 20090253205	patent-application	October 2009
Manufacture of Xylose-Based Fermentation Media from Corncobs by Posthydrolysis of Autohydrolysis Liquors Garrote, Gil; Domínguez, Herminia; Parajó, Juan C. Applied Biochemistry and Biotechnology, Vol. 95, Issue 3, p. 195-208 https://doi.org/10.1385/ABAB:95:3:195	journal	January 2001
Microbial process for producing L-ascorbic acid, D-erythorbic acid, and salts thereof Asakura, Akira; Hoshino, Tatsuo; Shinjoh, Masako https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6777212 US Patent Document 6,777,212	patent	August 2004
A thermoacidophilic endoglucanase (CelB) from Alicyclobacillus acidocaldarius displays high sequence similarity to arabinofuranosidases belonging to family 51 of glycoside hydrolases Eckert, Kelvin; Schneider, Erwin European Journal of Biochemistry, Vol. 270, Issue 17, p. 3593-3602 https://doi.org/10.1046/j.1432-1033.2003.03744.x	journal	August 2003
Biochemistry and genetics of microbial xylanases Jeffries, Thomas W. Current Opinion in Biotechnology, Vol. 7, Issue 3, p. 337-342 https://doi.org/10.1016/S0958-1669(96)80041-3	journal	June 1996
Analytical strategies for the use of DNA probes Matthews, Jayne A.; Kricka, Larry J. Analytical Biochemistry, Vol. 169, Issue 1, p. 1-25 https://doi.org/10.1016/0003-2697(88)90251-5	journal	February 1988
Plasmid, method for construction of the same, microorganism carrying the plasmid and method for cultivation of the microorganism Horikoshi, Koki; Kudo, Toshiaki; Honda, Hiroshi https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4624922 US Patent Document 4,624,922	patent	November 1986
Process for pretreating cellulosic substrates and for producing sugar therefrom Grethlein, Hans E. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4237226 US Patent Document 4,237,226	patent	December 1980
High temperature and alkaline stable catalase Thompson, Vicki; Apel, William A.; Schaller, Kastli D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050112742 US Patent Application 10/981434; 20050112742	patent-application	May 2005
Thermophilic and thermoacidophilic glycosylation genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods Thompson, David N.; Apel, William A.; Thompson, Vicki S. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090263859 US Patent Application 12/380450; 20090263859	patent-application	October 2009
Identification of essential genes in microorganisms Wang, Liangsu; Zamudio, Carlos; Malone, Cheryl https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040029129 US Patent Application 10/282122; 20040029129	patent-application	February 2004
Preliminary Investigation of Fungal Bioprocessing of Wheat Straw for Production of Straw-Thermoplastic Composites Thompson, David N.; Houghton, Tracy P.; Lacey, Jeffrey A. Biotechnology for Fuels and Chemicals, p. 423-436 https://doi.org/10.1007/978-1-4612-0057-4_35	book	January 2003
Cellulase-free xylanases from Bacillus and other microorganisms Subramaniyan, S.; Prema, P. FEMS Microbiology Letters, Vol. 183, Issue 1, p. 1-7 https://doi.org/10.1111/j.1574-6968.2000.tb08925.x	journal	February 2000
Single molecule detection of RNA reporter probes by amplification with Qβ replicase Burg, Lawrence J.; Juffras, Ann Marie; Wu, Ye Molecular and Cellular Probes, Vol. 10, Issue 4, p. 257-271 https://doi.org/10.1006/mcpr.1996.0035	journal	August 1996
Functional reconstitution of a maltose ATP-binding cassette transporter from the thermoacidophilic gram-positive bacterium Alicyclobacillus acidocaldarius Scheffel, Frank; Fleischer, Rebecca; Schneider, Erwin Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1656, Issue 1, p. 57-65 https://doi.org/10.1016/j.bbabio.2004.01.005	journal	May 2004
Bacterial glycoproteins: Functions, biosynthesis and applications Upreti, Raj K.; Kumar, Manoj; Shankar, V. PROTEOMICS, Vol. 3, Issue 4, p. 363-379 https://doi.org/10.1002/pmic.200390052	journal	April 2003
Overview and Evaluation of Fuel Ethanol from Cellulosic Biomass: Technology, Economics, the Environment, and Policy Lynd, Lee R. Annual Review of Energy and the Environment, Vol. 21, Issue 1, p. 403-465 https://doi.org/10.1146/annurev.energy.21.1.403	journal	November 1996
Rapid production of thermostable cellulase-free xylanase by a strain of Bacillus subtilis and its properties Sá-Pereira, Paula; Mesquita, Alexandra; Duarte, José C. Enzyme and Microbial Technology, Vol. 30, Issue 7, p. 924-933 https://doi.org/10.1016/S0141-0229(02)00034-0	journal	June 2002
Microbial β-Glucosidases: Cloning, Properties, and Applications Bhatia, Yukti; Mishra, Saroj; Bisaria, V. S. Critical Reviews in Biotechnology, Vol. 22, Issue 4, p. 375-407 https://doi.org/10.1080/07388550290789568	journal	January 2002
Crystallographic and mutational analyses of an extremely acidophilic and acid-stable xylanase: biased distribution of acidic residues and importance of Asp37 for catalysis at low pH Fushinobu, S.; Ito, K.; Konno, M. Protein Engineering Design and Selection, Vol. 11, Issue 12, p. 1121-1128 https://doi.org/10.1093/protein/11.12.1121	journal	December 1998
Synthesis of an amplifiable reporter RNA for bioassays Chu, Barbara C. F.; Kramer, Fred Russell; Orgel, Leslie E. Nucleic Acids Research, Vol. 14, Issue 14, p. 5591-5603 https://doi.org/10.1093/nar/14.14.5591	journal	January 1986
Characterization of a new bacteriophage which infects bacteria of the genus Acidiphilium Ward, T. E.; Bruhn, D. F.; Shean, M. L. Journal of General Virology, Vol. 74, Issue 11, p. 2419-2425 https://doi.org/10.1099/0022-1317-74-11-2419	journal	November 1993
Genetic elements, proteins, and associated methods including application of additional genetic information to gram (+) thermoacidophiles Lee, Brady; Newby, Deborah; Lacey, Jeffrey https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110275135 US Patent Application 12/800045; 20110275135	patent-application	November 2011
Oxygen effects on thermophilic microbial populations in biofilters treating nitric oxide containing off-gas streams Lee, Brady D.; Apel, William A.; Smith, William A. Environmental Progress, Vol. 20, Issue 3, p. 157-166 https://doi.org/10.1002/ep.670200311	journal	October 2001
‘Pseudomonas stutzeri’ strain and process for preparation of xylanase Bhosle, Narayan Baburao; Giriyan, Asha https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6833259 US Patent Document 6,833,259	patent	December 2004
Transcriptional control in alicyclobacillus acidocaldarius and associated genes, proteins, and methods Lee, Brady D.; Thompson, David N.; Apel, William A. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090215168 US Patent Application 12/380008; 20090215168	patent-application	August 2009
Thermostable .alpha.-L-arabinofuranosidase from Aureobasidium pullulans Saha, Badal C.; Bothast, Rodney J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5882905 US Patent Document 5,882,905	patent	March 1999
Current applications of COS cell based transient expression systems Edwards, Caroline P.; Aruffo, Alejandro Current Opinion in Biotechnology, Vol. 4, Issue 5, p. 558-563 https://doi.org/10.1016/0958-1669(93)90077-A	journal	October 1993
Isothermal in vitro amplification of DNA by a restriction enzyme/DNA polymerase system. Walker, G. T.; Little, M. C.; Nadeau, J. G. Proceedings of the National Academy of Sciences, Vol. 89, Issue 1, p. 392-396 https://doi.org/10.1073/pnas.89.1.392	journal	January 1992
Autocatalytic replication of a recombinant RNA Miele, Eleanor A.; Mills, Donald R.; Kramer, Fred Russell Journal of Molecular Biology, Vol. 171, Issue 3, p. 281-295 https://doi.org/10.1016/0022-2836(83)90094-3	journal	December 1983
Polypeptides of Alicyclobacillus sp. Wilting, Reinhard; Lassen, Soren Flensted; Ostergaard, Peter Rahbek https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070082381 US Patent Application 11/636950; 20070082381	patent-application	April 2007
Polymerase chain reaction Erlich, Henry A. Journal of Clinical Immunology, Vol. 9, Issue 6, p. 437-447 https://doi.org/10.1007/BF00918012	journal	November 1989
Transformation of Acidiphilium by electroporation and conjugation Glenn, Anne W.; Roberto, Frank F.; Ward, Thomas E. Canadian Journal of Microbiology, Vol. 38, Issue 5, p. 387-393 https://doi.org/10.1139/m92-065	journal	May 1992
Thermal and acid tolerant beta xylosidases, arabinofuranosidases, genes encoding, related organisms, and methods Thompson, David N.; Thompson, Vicki S.; Schaller, Kastli D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100311110 US Patent Application 12/802911; 20100311110	patent-application	December 2010
An extremely thermostable xylanase from the thermophilic eubacterium Thermotoga Simpson, H D; Haufler, U R; Daniel, R M Biochemical Journal, Vol. 277, Issue 2, p. 413-417 https://doi.org/10.1042/bj2770413	journal	July 1991
Thermoacidophilic Microorganisms and their Novel Biocatalysts Bertoldo, C.; Dock, C.; Antranikian, G. Engineering in Life Sciences, Vol. 4, Issue 6, p. 521-532 https://doi.org/10.1002/elsc.200402155	journal	December 2004
Method of detecting and characterizing a nucleic acid or reactant for the application of this method Kourilsky, Philippe; Avrameas, Stratis; Cami nee Contamine, Brigitte https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4581333 US Patent Document 4,581,333	patent	April 1986
Products and processes for in vitro synthesis of biomolecules Katzen, Federico; Kudlicki, Wieslaw; Fletcher, Julia https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060211083 US Patent Application 11/336644; 20060211083	patent-application	September 2006
Powers and Pitfalls in Sequence Analysis: The 70% Hurdle Bork, P. Genome Research, Vol. 10, Issue 4, p. 398-400 https://doi.org/10.1101/gr.10.4.398	journal	April 2000
Dilute-Sulfuric Acid Pretreatment of Corn Stover in Pilot-Scale Reactor: Investigation of Yields, Kinetics, and Enzymatic Digestibilities of Solids Schell, Daniel J.; Farmer, Jody; Newman, Millie Applied Biochemistry and Biotechnology, Vol. 105, Issue 1-3, p. 69-86 https://doi.org/10.1385/ABAB:105:1-3:69	journal	January 2003
Purification, characterization, and gene cloning of thermopsin, a thermostable acid protease from Sulfolobus acidocaldarius. Lin, X.; Tang, J. Journal of Biological Chemistry, Vol. 265, Issue 3 https://doi.org/10.1016/S0021-9258(19)40043-4	journal	January 1990
Polypeptides having haloperoxidase activity Danielsen, Steffen; Schneider, Palle https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6506585 US Patent Document 6,506,585	patent	January 2003
Recent advances in heterologous gene expression in Escherichia coli Olins, Peter O.; Lee, Stephen C. Current Opinion in Biotechnology, Vol. 4, Issue 5, p. 520-525 https://doi.org/10.1016/0958-1669(93)90071-4	journal	October 1993
Compositions and methods for the synthesis and subsequent modification of uridine-5'-diphosphosulfoquinovose (UDP-SQ) Benning, Christoph; Sanda, Sherrie Lea; Yu, Bin https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070134778 US Patent Application 11/590541; 20070134778	patent-application	June 2007
Promoters and proteins from Clostridium thermocellum and uses thereof Wu, J.H. David; Newcomb, Michael https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060105442 US Patent Application 11/271287; 20060105442	patent-application	May 2006
Thermophilic and thermoacidophilic metabolism genes and enzymes from alicyclobacillus acidocaldadarius and related organisms, methods Thompson, Vicki S.; Apel, William A.; Reed, David W https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090269827 US Patent Application 12/380551; 20090269827	patent-application	October 2009
Xylanases, xylanase families and extremophilic xylanases Collins, Tony; Gerday, Charles; Feller, Georges FEMS Microbiology Reviews, Vol. 29, Issue 1, p. 3-23 https://doi.org/10.1016/j.femsre.2004.06.005	journal	January 2005
X-ray Structures of the Maltose–Maltodextrin-binding Protein of the Thermoacidophilic Bacterium Alicyclobacillus acidocaldarius Provide Insight into Acid Stability of Proteins Schäfer, Karsten; Magnusson, Ulrika; Scheffel, Frank Journal of Molecular Biology, Vol. 335, Issue 1, p. 261-274 https://doi.org/10.1016/j.jmb.2003.10.042	journal	January 2004
Measurement of fumonisins in corn with a fiber optic fluoroimmunosensor Thompson, Vicki S.; Maragos, Chris M.; Thompson, Richard B. Advances in Fluorescence Sensing Technology III, Vol. 2980 https://doi.org/10.1117/12.273560	conference	May 1997
Purification and Characterization of a Novel Thermo-Alkali-Stable Catalase from Thermus brockianus Thompson, Vicki S.; Schaller, Kastli D.; Apel, William A. Biotechnology Progress, Vol. 19, Issue 4, p. 1292-1299 https://doi.org/10.1021/bp034040t	journal	January 2003
Genes encoding two different beta-glucosidases of Thermoanaerobacter brockii are clustered in a common operon. Breves, R.; Bronnenmeier, K.; Wild, N. Applied and environmental microbiology, Vol. 63, Issue 10 https://doi.org/10.1128/aem.63.10.3902-3910.1997	journal	January 1997
Specificity of the protein secretory apparatus: secretion of the heat-labile enterotoxin B subunit pentamers by different species of Gram- bacteria Michel, Linda Overbye; Sandkvist, Maria; Bagdasarian, Michael Gene, Vol. 152, Issue 1, p. 41-45 https://doi.org/10.1016/0378-1119(94)00691-K	journal	January 1995
Dilute Acid Pretreatment, Enzymatic Saccharification, and Fermentation of Rice Hulls to Ethanol Saha, Badal C.; Iten, Loren B.; Cotta, Michael A. Biotechnology Progress, Vol. 21, Issue 3, p. 816-822 https://doi.org/10.1021/bp049564n	journal	January 2005
Development of gas phase bioreactors for the removal of nitrogen oxides from synthetic flue gas streams Flanagan, William P.; Apel, William A.; Barnes, Joni M. Fuel, Vol. 81, Issue 15, p. 1953-1961 https://doi.org/10.1016/S0016-2361(02)00130-8	journal	October 2002
The Path Forward for Biofuels and Biomaterials Ragauskas, Arthur J.; Williams, Charlotte K.; Davison, Brian H. Science, Vol. 311, Issue 5760, p. 484-489 https://doi.org/10.1126/science.1114736	journal	January 2006
Alteration and modulation of protein activity by varying post-translational modification Thompson, David N.; Reed, David W.; Thompson, Vicki S. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100203583 US Patent Application 12/655993; 20100203583	patent-application	August 2010
Xylanase derived from a Bacillus species, expression vectors for such xylanase and other proteins, host organisms therefor and use thereof De Buyl, Eric; Lahaye, Andrée; Ledoux, Pierre https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6426211 US Patent Document 6,426,211	patent	July 2002
Partial acid hydrolysis of cellulosic materials as a pretreatment for enzymatic hydrolysis Knappert, Diane; Grethlein, Hans; Converse, Alvin Biotechnology and Bioengineering, Vol. 22, Issue 7, p. 1449-1463 https://doi.org/10.1002/bit.260220711	journal	July 1980
Ethanol from lignocellulosic biomass techno-economic performance in short-, middle- and long-term Hamelinck, Carlo N; Hooijdonk, Geertje van; Faaij, André PC Biomass and Bioenergy, Vol. 28, Issue 4, p. 384-410 https://doi.org/10.1016/j.biombioe.2004.09.002	journal	April 2005
Thermostable xylanases Gronberg, Vidar; Forster, Simon; Moody, Dean https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6083733 US Patent Document 6,083,733	patent	July 2000
Melamine Deaminase and Atrazine Chlorohydrolase: 98 Percent Identical but Functionally Different Seffernick, J. L.; de Souza, M. L.; Sadowsky, M. J. Journal of Bacteriology, Vol. 183, Issue 8, p. 2405-2410 https://doi.org/10.1128/JB.183.8.2405-2410.2001	journal	April 2001
Immunogenicity and protective efficacy of a tuberculosis DNA vaccine Huygen, Kris; Content, Jean; Denis, Olivier Nature Medicine, Vol. 2, Issue 8, p. 893-898 https://doi.org/10.1038/nm0896-893	journal	August 1996
Catalytic Plasticity of Fatty Acid Modification Enzymes Underlying Chemical Diversity of Plant Lipids Broun, Pierre; Shanklin, John; Whittle, Ed Science, Vol. 282, Issue 5392, p. 1315-1317 https://doi.org/10.1126/science.282.5392.1315	journal	November 1998
A general method applicable to the search for similarities in the amino acid sequence of two proteins Needleman, Saul B.; Wunsch, Christian D. Journal of Molecular Biology, Vol. 48, Issue 3, p. 443-453 https://doi.org/10.1016/0022-2836(70)90057-4	journal	March 1970
The Effect of Flow Rate of Compressed Hot Water on Xylan, Lignin, and Total Mass Removal from Corn Stover Liu, Chaogang; Wyman, Charles E. Industrial & Engineering Chemistry Research, Vol. 42, Issue 21, p. 5409-5416 https://doi.org/10.1021/ie030458k	journal	September 2003
Electrotransformation of Acidophilic, Heterotrophic, Gram-negative Bacteria Ward, Thomas E.; Eynard, Natalie; Teissié, Justin Electrotransformation of Bacteria, p. 94-103 https://doi.org/10.1007/978-3-662-04305-9_11	book	January 2000
Yeast systems for the expression of heterologous gene products Buckholz, Richard G. Current Opinion in Biotechnology, Vol. 4, Issue 5, p. 538-542 https://doi.org/10.1016/0958-1669(93)90074-7	journal	October 1993
Generation of transposon insertion mutant libraries for Gram-positive bacteria by electroporation of phage Mu DNA transposition complexes Pajunen, M. I. Microbiology, Vol. 151, Issue 4, p. 1209-1218 https://doi.org/10.1099/mic.0.27807-0	journal	April 2005
Transcription-based amplification system and detection of amplified human immunodeficiency virus type 1 with a bead-based sandwich hybridization format. Kwoh, D. Y.; Davis, G. R.; Whitfield, K. M. Proceedings of the National Academy of Sciences, Vol. 86, Issue 4, p. 1173-1177 https://doi.org/10.1073/pnas.86.4.1173	journal	February 1989
Simultaneous saccharification and fermentation of cellulose: Effect of ethanol on enzymatic saccharification of cellulose Ooshima, Hiroshi; Ishitani, Yohsuke; Harano, Yoshio Biotechnology and Bioengineering, Vol. 27, Issue 4, p. 389-397 https://doi.org/10.1002/bit.260270402	journal	April 1985
Comparison of pretreatment methods on the basis of available surface area Thompson, David N.; Chen, Hsin-Chih; Grethlein, Hans E. Bioresource Technology, Vol. 39, Issue 2, p. 155-163 https://doi.org/10.1016/0960-8524(92)90135-K	journal	January 1992
The acid hydrolysis of sugarcane bagasse hemicellulose to produce xylose, arabinose, glucose and other products Lavarack, B. P.; Griffin, G. J.; Rodman, D. Biomass and Bioenergy, Vol. 23, Issue 5, p. 367-380 https://doi.org/10.1016/S0961-9534(02)00066-1	journal	November 2002
Xyloglucan-specific alkaline xyloglucanase from bacillus Schulein, Martin; Outtrup, Helle; Jorgensen, Per Lina https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6268197 US Patent Document 6,268,197	patent	July 2001
A new class of biodegradable materials: Poly-3-hydroxy-butyrate/steam exploded straw fiber composites. I. Thermal and impact behavior Avella, Maurizio; Martuscelli, Ezio; Pascucci, Beniamino Journal of Applied Polymer Science, Vol. 49, Issue 12, p. 2091-2103 https://doi.org/10.1002/app.1993.070491205	journal	September 1993
Biomechanical and Biochemical Pulping of Sugarcane Bagasse with Ceriporiopsis subvermispora Fungal and Xylanase Pretreatments Ramos, Juan; González, Mercedes; Ramírez, Felipe Journal of Agricultural and Food Chemistry, Vol. 49, Issue 3, p. 1180-1186 https://doi.org/10.1021/jf0011586	journal	March 2001
Molecular diversity of thermophilic cellulolytic and hemicellulolytic bacteria Bergquist, Peter L.; Gibbs, Moreland D.; Morris, Daniel D. FEMS Microbiology Ecology, Vol. 28, Issue 2, p. 99-110 https://doi.org/10.1111/j.1574-6941.1999.tb00565.x	journal	February 1999
Potential and utilization of thermophiles and thermostable enzymes in biorefining Turner, Pernilla; Mamo, Gashaw; Karlsson, Eva Microbial Cell Factories, Vol. 6, Issue 1, 9 https://doi.org/10.1186/1475-2859-6-9	journal	January 2007
Fungal Upgrading of Wheat Straw for Straw-Thermoplastics Production Houghton, Tracy P.; Thompson, David N.; Hess, J. Richard Applied Biochemistry and Biotechnology, Vol. 113, Issue 1-3, p. 71-93 https://doi.org/10.1385/ABAB:113:1-3:071	journal	January 2004
Interlaboratory testing of methods for assay of xylanase activity Bailey, Michael J.; Biely, Peter; Poutanen, Kaisa Journal of Biotechnology, Vol. 23, Issue 3, p. 257-270 https://doi.org/10.1016/0168-1656(92)90074-J	journal	May 1992
Glycosidases and glycosyl transferases in glycoside and oligosaccharide synthesis Crout, David H. G.; Vic, Gabin Current Opinion in Chemical Biology, Vol. 2, Issue 1, p. 98-111 https://doi.org/10.1016/S1367-5931(98)80041-0	journal	February 1998
Enzyme and methodology for the treatment of a biomass Thompson, Vicki S.; Thompson, David N.; Schaller, Kastli D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7727755 US Patent Document 7,727,755	patent	June 2010
Purification, Properties and Structural Aspects of a Thermoacidophilic alpha-Amylase from Alicyclobacillus Acidocaldarius Atcc 27009 Schwermann, Birgit; Pfau, Karsten; Liliensiek, Birgit European Journal of Biochemistry, Vol. 226, Issue 3, p. 981-991 https://doi.org/10.1111/j.1432-1033.1994.00981.x	journal	December 1994
Gene cloning, sequencing, and characterization of a family 9 endoglucanase (CelA) with an unusual pattern of activity from the thermoacidophile Alicyclobacillus acidocaldarius ATCC27009 K., Eckert; F., Zielinski; Leggio, L. Lo Applied Microbiology and Biotechnology, Vol. 60, Issue 4, p. 428-436 https://doi.org/10.1007/s00253-002-1131-4	journal	December 2002
Industrial Scale-Up of pH-Controlled Liquid Hot Water Pretreatment of Corn Fiber for Fuel Ethanol Production Mosier, Nathan S.; Hendrickson, Richard; Brewer, Mark Applied Biochemistry and Biotechnology, Vol. 125, Issue 2, p. 77-98 https://doi.org/10.1385/ABAB:125:2:077	journal	January 2005
Purification and characterization of an acidophilic xylanase from Aureobasidium pullulans var. melanigenum and sequence analysis of the encoding gene Ohta, Kazuyoshi; Moriyama, Satoshi; Tanaka, Hidenori Journal of Bioscience and Bioengineering, Vol. 92, Issue 3, p. 262-270 https://doi.org/10.1016/S1389-1723(01)80260-7	journal	January 2001
Purification and Properties of Two Thermostable Alkaline Xylanases from an Alkaliphilic Bacillussp Gessesse, Amare Applied and Environmental Microbiology, Vol. 64, Issue 9 https://doi.org/10.1128/AEM.64.9.3533-3535.1998	journal	September 1998
Deciphering the message in protein sequences: tolerance to amino acid substitutions Bowie, J.; Reidhaar-Olson, J.; Lim, W. Science, Vol. 247, Issue 4948, p. 1306-1310 https://doi.org/10.1126/science.2315699	journal	March 1990
Cloning and characterization of two glycosidases from the acidothermophile Alicyclobacillus acidocaldarius ATCC27009 Eckert, Kelvin Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I https://doi.org/10.18452/15013	text	January 2004
Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods Thompson, David N.; Apel, William A.; Thompson, Vicki S. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090203107 US Patent Apllication 12/322359; 20090203107	patent-application	August 2009
Thermostable xylanase Fukunaga, Nobuyuki; Iwasaki, Yuji; Kono, Satoko https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5916795 US Patent Document 5,916,795	patent	June 1999

Similar Records

Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes

Patent · Tue Mar 22 00:00:00 EDT 2016 · OSTI ID:1088690

Thompson, David N.; Apel, William A.; Thompson, Vicki S.; +1 more

Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes

Patent · Tue Apr 08 00:00:00 EDT 2014 · OSTI ID:1088690

Thompson, David N; Apel, William A; Thompson, Vicki S; +1 more

Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes

Patent · Tue Aug 15 00:00:00 EDT 2017 · OSTI ID:1088690

Thompson, David N.; Apel, William A.; Thompson, Vicki S.; +1 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES

Title: Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes

Citation Formats

References (117)

Similar Records

Related Subjects