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Title: Genetically modified yeast species, and fermentation processes using genetically modified yeast

Abstract

Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.

Inventors:
; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Cargill, Incorporated (Wayzata, MN)
Sponsoring Org.:
USDOE
OSTI Identifier:
1084065
Patent Number(s):
8,440,451
Application Number:
13/107,881
Assignee:
Cargill, Incorporated (Wayzata, MN)
DOE Contract Number:  
FC07-02ID14349
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Rajgarhia, Vineet, Koivuranta, Kari, Penttila, Merja, Ilmen, Marja, Suominen, Pirkko, Aristidou, Aristos, Miller, Christopher Kenneth, Olson, Stacey, and Ruohonen, Laura. Genetically modified yeast species, and fermentation processes using genetically modified yeast. United States: N. p., 2013. Web.
Rajgarhia, Vineet, Koivuranta, Kari, Penttila, Merja, Ilmen, Marja, Suominen, Pirkko, Aristidou, Aristos, Miller, Christopher Kenneth, Olson, Stacey, & Ruohonen, Laura. Genetically modified yeast species, and fermentation processes using genetically modified yeast. United States.
Rajgarhia, Vineet, Koivuranta, Kari, Penttila, Merja, Ilmen, Marja, Suominen, Pirkko, Aristidou, Aristos, Miller, Christopher Kenneth, Olson, Stacey, and Ruohonen, Laura. 2013. "Genetically modified yeast species, and fermentation processes using genetically modified yeast". United States. https://www.osti.gov/servlets/purl/1084065.
@article{osti_1084065,
title = {Genetically modified yeast species, and fermentation processes using genetically modified yeast},
author = {Rajgarhia, Vineet and Koivuranta, Kari and Penttila, Merja and Ilmen, Marja and Suominen, Pirkko and Aristidou, Aristos and Miller, Christopher Kenneth and Olson, Stacey and Ruohonen, Laura},
abstractNote = {Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.},
doi = {},
url = {https://www.osti.gov/biblio/1084065}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {5}
}

Works referenced in this record:

Evidence that the gene YLR070c of Saccharomyces cerevisiae encodes a xylitol dehydrogenase
journal, August 1999


Transformation in fungi.
journal, January 1989


Molecular and industrial aspects of glucose isomerase.
journal, January 1996


Minimal metabolic engineering of for efficient anaerobic xylose fermentation a proof of principle
journal, March 2004


Xylose metabolism in the anaerobic fungus Piromyces sp. strain E2 follows the bacterial pathway
journal, June 2003


Yeast vectors for integration at the HO locus
journal, June 2001


Role of D-ribose as a cometabolite in D-xylose metabolism by Saccharomyces cerevisiae
journal, May 1993


Amino Acid Substitutions in the Yeast Pichia Stipitis Xylitol Dehydrogenase Coenzyme-Binding Domain Affect the Coenzyme Specificity
journal, February 1995