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Title: Genetically modified yeast species, and fermentation processes using genetically modified yeast

Patent ·
OSTI ID:1084065
; ; ; ; ; ; ; ;

Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.

Research Organization:
Cargill, Incorporated (Wayzata, MN)
Sponsoring Organization:
USDOE
DOE Contract Number:
FC07-02ID14349
Assignee:
Cargill, Incorporated (Wayzata, MN)
Patent Number(s):
8,440,451
Application Number:
13/107,881
OSTI ID:
1084065
Country of Publication:
United States
Language:
English

References (16)

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Xylose isomerase activity influences xylose fermentation with recombinant Saccharomyces cerevisiae strains expressing mutated xylA from Thermus thermophilus journal April 2003
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Xylose metabolism in the anaerobic fungus Piromyces sp. strain E2 follows the bacterial pathway journal June 2003
Yeast vectors for integration at the HO locus journal June 2001
Xylose isomerase with improved properties patent November 2002
Role of D-ribose as a cometabolite in D-xylose metabolism by Saccharomyces cerevisiae journal May 1993
Isolation and characterization of acetic acid-tolerant galactose-fermenting strains of Saccharomyces cerevisiae from a spent sulfite liquor fermentation plant. journal January 1992
Amino Acid Substitutions in the Yeast Pichia Stipitis Xylitol Dehydrogenase Coenzyme-Binding Domain Affect the Coenzyme Specificity journal February 1995
High-level functional expression of a fungal xylose isomerase: the key to efficient ethanolic fermentation of xylose by ? journal October 2003
Deletion of the GRE3 Aldose Reductase Gene and Its Influence on Xylose Metabolism in Recombinant Strains of Saccharomyces cerevisiae Expressing the xylA and XKS1 Genes journal December 2001

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