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Title: System and process for pulsed multiple reaction monitoring

Abstract

A new pulsed multiple reaction monitoring process and system are disclosed that uses a pulsed ion injection mode for use in conjunction with triple-quadrupole instruments. The pulsed injection mode approach reduces background ion noise at the detector, increases amplitude of the ion signal, and includes a unity duty cycle that provides a significant sensitivity increase for reliable quantitation of proteins/peptides present at attomole levels in highly complex biological mixtures.

Inventors:
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1084053
Patent Number(s):
8,440,963
Application Number:
12/871,685
Assignee:
Battelle Memorial Institute (Richland, WA) RLO
DOE Contract Number:  
AC05-76RLO5640
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Belov, Mikhail E. System and process for pulsed multiple reaction monitoring. United States: N. p., 2013. Web.
Belov, Mikhail E. System and process for pulsed multiple reaction monitoring. United States.
Belov, Mikhail E. Fri . "System and process for pulsed multiple reaction monitoring". United States. https://www.osti.gov/servlets/purl/1084053.
@article{osti_1084053,
title = {System and process for pulsed multiple reaction monitoring},
author = {Belov, Mikhail E},
abstractNote = {A new pulsed multiple reaction monitoring process and system are disclosed that uses a pulsed ion injection mode for use in conjunction with triple-quadrupole instruments. The pulsed injection mode approach reduces background ion noise at the detector, increases amplitude of the ion signal, and includes a unity duty cycle that provides a significant sensitivity increase for reliable quantitation of proteins/peptides present at attomole levels in highly complex biological mixtures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {5}
}

Patent:

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