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Title: Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof

Abstract

The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity halogenated, carborane-containing 5,10,15,20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these halogenated, carborane-containing tetraphenylporphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.

Inventors:
;
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1084033
Patent Number(s):
8,444,953
Application Number:
11/689,678
Assignee:
Brookhaven Science Associates, LLC (Upton, NY)
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Miura, Michiko, and Wu, Haitao. Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof. United States: N. p., 2013. Web.
Miura, Michiko, & Wu, Haitao. Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof. United States.
Miura, Michiko, and Wu, Haitao. Tue . "Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof". United States. https://www.osti.gov/servlets/purl/1084033.
@article{osti_1084033,
title = {Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof},
author = {Miura, Michiko and Wu, Haitao},
abstractNote = {The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity halogenated, carborane-containing 5,10,15,20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these halogenated, carborane-containing tetraphenylporphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {5}
}

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