Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof

Miura, Michiko; Wu, Haitao

Title: Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof

Patent · Tue May 21 00:00:00 EDT 2013

OSTI ID:1084033

Miura, Michiko; Wu, Haitao

The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity halogenated, carborane-containing 5,10,15,20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these halogenated, carborane-containing tetraphenylporphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-98CH10886

Assignee:: Brookhaven Science Associates, LLC (Upton, NY)

Patent Number(s):: 8,444,953

Application Number:: 11/689,678

OSTI ID:: 1084033

Country of Publication:: United States

Language:: English

References (71)

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