Anti-cancer agents based on N-acyl-2, 3-dihydro-1H-pyrrolo[2,3-b] quinoline derivatives and a method of making
The present disclosure relates to novel compounds that can be used as anti-cancer agents in the prostate cancer therapy. In particular, the invention relates to N-acyl derivatives of 2,3-dihydro-1H-pyrrolo[2,3-b]quinolines having the structural Formula (I), ##STR00001## stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof. The meaning of R1 is independently selected from H; C1-C6 Alkyl, cyclo-Alkyl or iso-Alkyl substituents; R2 is selected from C1-C6 Alkyl, cyclo-Alkyl or iso-Alkyl; substituted or non-substituted, fused or non-fused to substituted or non-substituted aromatic ring, aryl or heteroaryl groups. The invention also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.
- Research Organization:
- US Department of Energy (USDOE), Washington, DC (United States)
- Sponsoring Organization:
- USDOE
- Assignee:
- U.S. Department of Energy (Washington, DC)
- Patent Number(s):
- 8,420,815
- Application Number:
- 12/822,237
- OSTI ID:
- 1083454
- Country of Publication:
- United States
- Language:
- English
Synthesis and cytotoxic activity of substituted Luotonin A derivatives
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journal | December 2004 |
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