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Recombinant microorganisms for increased production of organic acids

Patent ·
OSTI ID:1083279
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Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.

Research Organization:
Michigan Biotechnology Institute (Lansing, MI)
Sponsoring Organization:
USDOE
DOE Contract Number:
FC36-02GO12001
Assignee:
Michigan Biotechnology Institute (Lansing, MI)
Patent Number(s):
8,431,373
Application Number:
13/328,894
OSTI ID:
1083279
Country of Publication:
United States
Language:
English

References (7)

Production of succinic acid through overexpression of NAD(+)-dependent malic enzyme in an Escherichia coli mutant. journal January 1997
Actinobacillus succinogenes sp. nov., a novel succinic-acid-producing strain from the bovine rumen journal January 1999
Utilization of Electrically Reduced Neutral Red byActinobacillus succinogenes: Physiological Function of Neutral Red in Membrane-Driven Fumarate Reduction and Energy Conservation journal January 1999
Biotechnology of succinic acid production and markets for derived industrial products journal May 1999
Molecular characterization of the Escherichia coli K-12 zwf gene encoding glucose 6-phosphate dehydrogenase. journal February 1991
Construction of a shuttle vector for the overexpression of recombinant proteins in Actinobacillus succinogenes journal March 2004
Environmental and physiological factors affecting the succinate product ratio during carbohydrate fermentation by Actinobacillus sp. 130Z journal May 1997

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES