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Method and apparatus for fluid dispersion

Patent ·
OSTI ID:1082144
A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
Research Organization:
President and Fellows of Harvard College (Cambridge, MA); The Governing Council of the Univ. of Toronto (Toronto, CA)
Sponsoring Organization:
USDOE
Assignee:
President and Fellows of Harvard College (Cambridge, MA) ; The Governing Council of the Univ. of Toronto (Toronto, CA)
Patent Number(s):
8,337,778
Application Number:
12/726,223
OSTI ID:
1082144
Country of Publication:
United States
Language:
English

References (71)

Electrocoalesce-separators for the separation of aqueous drops from a flowing dielectric viscous liquid journal October 2002
Miniaturising the laboratory in emulsion droplets journal September 2006
Capacitance cytometry: Measuring biological cells one by one journal September 2000
Controlled protein delivery from biodegradable tyrosine-containing poly(anhydride-co-imide) microspheres journal July 1997
Preparation of Silica Particles Encapsulating Retinol Using O/W/O Multiple Emulsions journal August 2001
Micro/Nano Encapsulation via Electrified Coaxial Liquid Jets journal March 2002
A Microfluidic System for Controlling Reaction Networks in Time journal February 2003
Production of lipospheres as carriers for bioactive compounds journal June 2002
Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles journal November 2002
Insulin-loaded biodegradable PLGA microcapsules: initial burst release controlled by hydrophilic additives journal June 2002
The behaviour of a liquid–liquid interface and drop-interface coalescence under the influence of an electric field journal March 2003
Monodisperse Emulsion Generation via Drop Break Off in a Coflowing Stream journal January 2000
Research News journal December 2002
Generation of monodisperse gel emulsions in a microfluidic device journal January 2006
Double emulsions stabilized by new molecular recognition hybrids of natural polymers journal October 2002
Application of advanced cytometric and molecular technologies to minimal residual disease monitoring conference April 2000
Emulsion Liquid Membranes for Wastewater Treatment: Equilibrium Models for Some Typical Metal-Extractant Systems journal June 1994
Electrostatic enhancement of coalescence of water droplets in oil: a review of the technology journal January 2002
Controlled fission of droplet emulsion in bifurcating microfluidic channels
  • No authors listed
  • IEEE International Solid-State Sensors and Actuators Conference, TRANSDUCERS '03. 12th International Conference on Solid-State Sensors, Actuators and Microsystems. Digest of Technical Papers (Cat. No.03TH8664) https://doi.org/10.1109/SENSOR.2003.1215245
conference January 2003
Comparative study on sustained release of human growth hormone from semi-crystalline poly(l-lactic acid) and amorphous poly(d,l-lactic-co-glycolic acid) microspheres: morphological effect on protein release journal July 2004
Motion, deformation and break-up of aqueous drops in oils under high electric field strengths journal April 2003
Optimization of Droplet Generation by Controlling PDMS Surface Hydrophobicity conference January 2004
Microscale production of hybridomas by hypo-osmolar electrofusion journal March 1992
Distribution of Macropores in Silica Particles Prepared by Using Multiple Emulsions journal October 2002
Man-made cell-like compartments for molecular evolution journal July 1998
Preparation of a stable double emulsion (W1/O/W2): role of the interfacial films on the stability of the system journal December 2002
Capturing a Photoexcited Molecular Structure Through Time-Domain X-ray Absorption Fine Structure journal April 2001
Perfectly Monodisperse Microbubbling by Capillary Flow Focusing journal December 2001
Effective Formation of Silicone-in-Fluorocarbon-in-Water Double Emulsions: Studies on Droplet Morphology and Stability journal September 2002
A microfabricated fluorescence-activated cell sorter journal November 1999
Microfluidic Control Using Colloidal Devices journal June 2002
Single-molecule PCR using water-in-oil emulsion journal April 2003
Generation of Polymerosomes from Double-Emulsions journal September 2005
Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device journal April 2001
Monodisperse Double Emulsions Generated from a Microcapillary Device journal April 2005
Encapsulation of Bovine Serum Albumin in Temperature-Programmed“Shell-in-Shell” Structures journal November 2003
Control of concentration and volume gradients in microfluidic droplet arrays for protein crystallization screening conference January 2004
Fabrication of linear colloidal structures for microfluidic applications journal August 2002
W/O/W multiple emulsions of insulin containing a protease inhibitor and an absorption enhancer: biological activity after oral administration to normal and diabetic rats journal June 1998
Drug-releasing scaffolds fabricated from drug-loaded microspheres journal November 2001
One-Dimensional Simulation of the Breakup of Capillary jets of Conducting Liquids. Application to E.H.D. Spraying journal August 1999
Generation of Steady Liquid Microthreads and Micron-Sized Monodisperse Sprays in Gas Streams journal January 1998
Encapsulation of orange oil in a spray dried double emulsion journal April 2001
The burgeoning power of the shrinking laboratory journal November 1999
Man-made enzymes — from design to in vitro compartmentalisation journal August 2000
PLGA microspheres containing plasmid DNA: Preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization journal January 1999
An Axisymmetric Flow-Focusing Microfluidic Device journal April 2005
Coaxial jets generated from electrified Taylor cones. Scaling laws journal May 2003
Dewetting Instability during the Formation of Polymersomes from Block-Copolymer-Stabilized Double Emulsions journal May 2006
Microchip Device for Performing Enzyme Assays journal September 1997
A Microfluidic Approach for Screening Submicroliter Volumes against Multiple Reagents by Using Preformed Arrays of Nanoliter Plugs in a Three-Phase Liquid/Liquid/Gas Flow journal April 2005
Transdermal delivery of glucose through hairless rat skin in vitro: effect of multiple and simple emulsions journal September 1998
Microfluidic flow transducer based on the measurement of electrical admittance journal January 2004
Interfacial Tension Driven Monodispersed Droplet Formation from Microfabricated Channel Array journal September 2001
pH-sensitive microsphere delivery increases oral bioavailability of calcitonin journal July 2004
Formation of dispersions using “flow focusing” in microchannels journal January 2003
On the stability of ascorbic acid in emulsified systems for topical and cosmetic use journal October 1999
Electrostatic and hydrodynamic separation of aqueous drops in a flowing viscous oil journal September 2002
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays journal April 1999
Geometrically Mediated Breakup of Drops in Microfluidic Devices journal February 2004
Controlled formulation of monodisperse double emulsions in a multiple-phase microfluidic system journal January 2005
Controlled Production of Monodisperse Double Emulsions by Two-Step Droplet Breakup in Microfluidic Devices journal November 2004
Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting journal January 2004
Integrating advanced functionality in a microfabricated high-throughput fluorescent-activated cell sorter journal January 2003
Generation of Monodisperse Particles by Using Microfluidics: Control over Size, Shape, and Composition journal January 2005
Dielectrophoretic manipulation of drops for high-speed microfluidic sorting devices journal January 2006
Optimization of Shear Driven Droplet Generation in a Microfluidic Device conference January 2003
Degradation of porous poly(anhydride-co-imide) microspheres and implications for controlled macromolecule delivery journal January 1998
Controllable delivery of non-viral DNA from porous scaffolds journal January 2003
Microfluidic switch for embryo and cell sorting
  • Chen, C. C.; Zappe, S.; Sahin, O.
  • IEEE International Solid-State Sensors and Actuators Conference, TRANSDUCERS '03. 12th International Conference on Solid-State Sensors, Actuators and Microsystems. Digest of Technical Papers (Cat. No.03TH8664) https://doi.org/10.1109/SENSOR.2003.1215559
conference January 2003
Emulsions: basic principles journal January 1999

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