Carboranylporphyrins and uses thereof

Miura, Michiko; Renner, Mark W

Title: Carboranylporphyrins and uses thereof

Patent · Tue Oct 16 00:00:00 EDT 2012

OSTI ID:1079454

Miura, Michiko; Renner, Mark W

The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing porphyrin compounds with halide, amine, or nitro groups and methods for their use particularly in boron neutron capture therapy (BNCT), X-ray radiation therapy (XRT), and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing porphyrin compounds in methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-98CH10886

Assignee:: Brookhaven Science Associates, LLC (Upton, NY)

Patent Number(s):: 8,287,839

Application Number:: 11/633,139

OSTI ID:: 1079454

Country of Publication:: United States

Language:: English

References (33)

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