skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Methods of treating ovarian cancer by modulating SnoN

Patent ·
OSTI ID:1078515

Research Organization:
University of South Florida (Tampa, FL)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC03-76SF00098
Assignee:
University of South Florida (Tampa, FL)
Patent Number(s):
8,211,646
Application Number:
12/619,345
OSTI ID:
1078515
Country of Publication:
United States
Language:
English

References (69)

Inability of Transforming Growth Factor-β to Cause SnoN Degradation Leads to Resistance to Transforming Growth Factor-β–Induced Growth Arrest in Esophageal Cancer Cells journal June 2005
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? journal May 2009
Mutation analysis of the Smad3 gene in human ovarian cancers. journal November 1999
Crystal Structure of the Dachshund Homology Domain of Human SKI journal May 2004
Autophagic cell death unraveled: Pharmacological inhibition of apoptosis and autophagy enables necrosis journal May 2008
Targeted Degradation of the AML1/MDS1/EVI1 Oncoprotein by Arsenic Trioxide journal November 2006
TAK1 MAPK Kinase Kinase Mediates Transforming Growth Factor-β Signaling by Targeting SnoN Oncoprotein for Degradation journal February 2007
Extracellular heat shock protein 90: A role for a molecular chaperone in cell motility and cancer metastasis journal October 2007
Smurf2 up-regulation activates telomere-dependent senescence journal December 2004
Evi-1 ZF1 DNA binding activity and a second distinct transcriptional repressor region are both required for optimal transformation of Rat1 fibroblasts journal April 1998
Expression Profiling Identifies Altered Expression of Genes That Contribute to the Inhibition of Transforming Growth Factor-β Signaling in Ovarian Cancer journal September 2006
Requirement for the SnoN Oncoprotein in Transforming Growth Factor β-Induced Oncogenic Transformation of Fibroblast Cells journal December 2005
Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis journal September 2003
Comparative genomic hybridization reveals DNA copy number gains to frequently occur in human prostate cancer journal May 1999
Arsenic Trioxide inhibits the growth of human ovarian carcinoma cell line journal December 2005
Glutathione depletion overcomes resistance to arsenic trioxide in arsenic-resistant cell lines journal May 2003
Ski/Sno and TGF-β signaling journal March 2001
Arsenic trioxide reduces the invasive and metastatic properties of nasopharyngeal carcinoma cells in vitro journal May 2006
Critical regulation of TGF  signaling by Hsp90 journal June 2008
Investigations for Fine Mapping of Amplifications in Chromosome 3q26.3–28 Frequently Occurring in Squamous Cell Carcinomas of the Head and Neck journal January 2002
Synergism between Arsenic Trioxide and Heat Shock Protein 90 Inhibitors on Signal Transducer and Activator of Transcription Protein 3 Activity--Pharmacodynamic Drug-Drug Interaction Modeling journal April 2007
Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis journal March 2004
Identification of Binding Sites of EVI1 in Mammalian Cells journal July 2005
Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells journal May 2009
BRAFE600-associated senescence-like cell cycle arrest of human naevi journal August 2005
Inhibitory role of TGIF in the As2O3-regulated p21 WAF1/CIP1 expression journal January 2008
In search of an “autophagomometer” journal July 2009
Superoxide is the major reactive oxygen species regulating autophagy journal May 2009
HSP27 and HSP70: Potentially Oncogenic Apoptosis Inhibitors journal November 2003
Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression journal September 2006
Markers of senescence? journal January 2002
Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells journal May 2005
Arsenic trioxide, a therapeutic agent for APL journal October 2001
Oncogene-Induced Senescence: Putting the Brakes on Tumor Development: Figure 1. journal March 2006
Arkadia Activates Smad3/Smad4-Dependent Transcription by Triggering Signal-Induced SnoN Degradation journal June 2007
Negative Feedback Regulation of TGF- Signaling by the SnoN Oncoprotein journal October 1999
Assembly of microarrays for genome-wide measurement of DNA copy number journal October 2001
SnoN Is a Cell Type-specific Mediator of Transforming Growth Factor-β Responses journal January 2005
Arsenic trioxide induces apoptosis in cisplatin-sensitive and -resistant ovarian cancer cell lines journal September 2005
Proteasomal activity modulates TGF-ß signaling in a gene-specific manner journal August 2002
The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice journal May 2000
Molecular alterations of theAKT2 oncogene in ovarian and breast carcinomas journal August 1995
Novel amplification unit at chromosome 3q25-q27 in human prostate cancer journal January 2000
Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells journal January 2009
Arsenic trioxide induced the apoptosis of laryngeal cancer via down-regulation of survivin mRNA journal March 2008
Amplification of SKI Is a Prognostic Marker in Early Colorectal Cancer journal May 2004
Expression of active plasminogen activator inhibitor-1 reduces cell migration and invasion in breast and gynecological cancer cells journal June 2004
Sumoylated SnoN Represses Transcription in a Promoter-specific Manner journal September 2006
PML nuclear bodies: dynamic sensors of DNA damage and cellular stress journal January 2004
Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: Role of nuclear factor-κB and reactive oxygen species journal January 2005
The MRP1-Mediated Effluxes of Arsenic and Antimony Do Not Require Arsenic–Glutathione and Antimony–Glutathione Complex Formation journal April 2002
Increased expression of c-Ski as a co-repressor in transforming growth factor-? signaling correlates with progression of esophageal squamous cell carcinoma journal January 2004
Prognostic significance of urokinase (uPA) and its inhibitor PAI-1 for survival in advanced ovarian carcinoma stage FIGO IIIc journal March 1999
Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway journal December 2006
Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. journal February 1996
SKI pathways inducing progression of human melanoma journal June 2005
Effect of autophagy on multiple myeloma cell viability journal June 2009
Arkadia Induces Degradation of SnoN and c-Ski to Enhance Transforming Growth Factor-β Signaling journal May 2007
PIK3CA is implicated as an oncogene in ovarian cancer journal January 1999
Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: A role in ovarian pathogenesis journal May 2008
The Transforming Activity of Ski and SnoN Is Dependent on Their Ability to Repress the Activity of Smad Proteins journal May 2003
Oxidation as a Post-Translational Modification that Regulates Autophagy journal July 2007
SUMO: a regulator of gene expression and genome integrity journal March 2004
Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice journal December 2001
Transforming growth factor-beta inhibits proliferation of human ovarian cancer cells obtained from ascites journal July 1994
Arsenic trioxide inhibits proliferation in K562 cells by changing cell cycle and survivin expression
  • Xiaofei, Wu; Zhichao, Chen; Zhongping, Liu
  • Journal of Huazhong University of Science and Technology [Medical Sciences], Vol. 24, Issue 4 https://doi.org/10.1007/BF02861863
journal August 2004
Arsenic trioxide (As2O3) inhibits peritoneal invasion of ovarian carcinoma cells in vitro and in vivo journal October 2006
Breast cancer in young women (?35 years): Genomic aberrations detected by comparative genomic hybridization journal September 2003
Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C journal February 2006

Similar Records

Related Subjects