Amphiphiles for protein solubilization and stabilization
Patent
·
OSTI ID:1078330
The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
- Research Organization:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-06CH11357; W-31-109-ENG-38
- Assignee:
- Wisconsin Alumni Research Foundation (Madison, WI) ; UChicago Argonne, LLC (Chicago, IL)
- Patent Number(s):
- 8,263,754
- Application Number:
- 12/420,701
- OSTI ID:
- 1078330
- Country of Publication:
- United States
- Language:
- English
Glycotripod Amphiphiles for Solubilization and Stabilization of a Membrane‐Protein Superassembly: Importance of Branching in the Hydrophilic Portion
|
journal | July 2008 |
Synthesis of some aglycon analogs of globotriosylceramide
|
journal | December 1999 |
[11] The design and synthesis of detergents for membrane biochemistry
|
book | January 1986 |
Synthesis and mesogenic properties of a Y-shaped glyco-glycero-lipid
|
journal | August 2004 |
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