Synthetic LDL as targeted drug delivery vehicle
Abstract
The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.
- Inventors:
-
- Berkeley, CA
- Richmond, CA
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1061284
- Patent Number(s):
- 8,252,338
- Application Number:
- 12/084,845
- Assignee:
- The Regents of the University of California (Oakland, CA); Children's Hospital & Research Center Oakland (Oakland, CA)
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Forte, Trudy M, and Nikanjam, Mina. Synthetic LDL as targeted drug delivery vehicle. United States: N. p., 2012.
Web.
Forte, Trudy M, & Nikanjam, Mina. Synthetic LDL as targeted drug delivery vehicle. United States.
Forte, Trudy M, and Nikanjam, Mina. 2012.
"Synthetic LDL as targeted drug delivery vehicle". United States. https://www.osti.gov/servlets/purl/1061284.
@article{osti_1061284,
title = {Synthetic LDL as targeted drug delivery vehicle},
author = {Forte, Trudy M and Nikanjam, Mina},
abstractNote = {The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.},
doi = {},
url = {https://www.osti.gov/biblio/1061284},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 28 00:00:00 EDT 2012},
month = {Tue Aug 28 00:00:00 EDT 2012}
}
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