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Title: Synthetic LDL as targeted drug delivery vehicle

Abstract

The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.

Inventors:
 [1];  [2]
  1. Berkeley, CA
  2. Richmond, CA
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1061284
Patent Number(s):
8,252,338
Application Number:
12/084,845
Assignee:
The Regents of the University of California (Oakland, CA); Children's Hospital & Research Center Oakland (Oakland, CA) LBNL
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Forte, Trudy M, and Nikanjam, Mina. Synthetic LDL as targeted drug delivery vehicle. United States: N. p., 2012. Web.
Forte, Trudy M, & Nikanjam, Mina. Synthetic LDL as targeted drug delivery vehicle. United States.
Forte, Trudy M, and Nikanjam, Mina. Tue . "Synthetic LDL as targeted drug delivery vehicle". United States. https://www.osti.gov/servlets/purl/1061284.
@article{osti_1061284,
title = {Synthetic LDL as targeted drug delivery vehicle},
author = {Forte, Trudy M and Nikanjam, Mina},
abstractNote = {The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {8}
}

Patent:

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