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Title: Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin

Abstract

Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.

Authors:
; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1056153
Report Number(s):
PNNL-SA-89040
BM0101020
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Organic Letters, 14(22):5684-5687
Additional Journal Information:
Journal Name: Organic Letters, 14(22):5684-5687
Country of Publication:
United States
Language:
English

Citation Formats

Guo, Chun-Jun, Knox, Benjamin P., Chiang, Yi Ming, Lo, Hsien-Chun, Sanchez, James F., Lee, Kuan-Han, Oakley, Berl R., Bruno, Kenneth S., and Wang, Clay C. Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin. United States: N. p., 2012. Web. doi:10.1021/ol302682z.
Guo, Chun-Jun, Knox, Benjamin P., Chiang, Yi Ming, Lo, Hsien-Chun, Sanchez, James F., Lee, Kuan-Han, Oakley, Berl R., Bruno, Kenneth S., & Wang, Clay C. Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin. United States. doi:10.1021/ol302682z.
Guo, Chun-Jun, Knox, Benjamin P., Chiang, Yi Ming, Lo, Hsien-Chun, Sanchez, James F., Lee, Kuan-Han, Oakley, Berl R., Bruno, Kenneth S., and Wang, Clay C. Thu . "Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin". United States. doi:10.1021/ol302682z.
@article{osti_1056153,
title = {Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin},
author = {Guo, Chun-Jun and Knox, Benjamin P. and Chiang, Yi Ming and Lo, Hsien-Chun and Sanchez, James F. and Lee, Kuan-Han and Oakley, Berl R. and Bruno, Kenneth S. and Wang, Clay C.},
abstractNote = {Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.},
doi = {10.1021/ol302682z},
journal = {Organic Letters, 14(22):5684-5687},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {11}
}